Project description
'Safety-by-design' – Towards safer nanotechnology applications
High-performance engineered nanomaterials hold great promise for a variety of fields including medicine, electronics and energy. To achieve scalable quantities of nanomaterials that are safe to use, new methodologies for nanomaterial synthesis need to be explored, which will investigate the impact of nanomaterials on humans and the environment at the start of the process. One of the main goals of the EU-funded SABYDOMA project is to build high-throughput online platforms where nanomaterials are manufactured and screened at the point of production. Another goal is to extend the impact of safe-by-design nanomaterials to real-world situations. The project will examine four industrial case studies set up by four industrial partners to advance the technology readiness level from 4 to 6.
Objective
The SABYDOMA programme addresses developments in the safety by design (SbD) paradigm by examining four industrial case studies in detail where the TRLs will advance from 4 to 6. Each TRL activity will progress from being lab based at TRL4 to being industry based at TRL6. The TRL4 activity will involve only innovation with regular industrial communication whereas the TRL6 activity will involve industrially located activities with innovation communication. One of the novel themes of this study is to use system control and optimisation theory including the Model Predictive Control (MPC) philosophy to bind the whole subject of SbD from laboratory innovation to the industrial production line and from decision making processes to project governance. An equally important innovative step is the building of high throughput online platforms where nanomaterial (NM) is manufactured and screened at the point of production. The screening signal controls the NM redesign and production in a feedback loop. Screens will involve (a) physiochemical sensing elements (b) in-vitro targets of increasing complexity from the 2D biomembrane to cell-line and more complex cell-line elements; and, (c) multiple in-vitro targets with multiple end-points; developed in current H2020 projects. Two of the industrial studies include composite coating manufacture where the coating’s stability and toxicity will be tested using a flow through microfluidic flow cell system coupled to online screens. This is part of the release and ageing investigations on the NM and NM coatings and the results of these will feed back to the production line design. At every step on the TRL ladder the in-silico modelling will be applied to optimise and redefine the relevant activities. By the same token regulatory and governance principles of SbD will be used to refine the technological development. The final deliverable will be four distinct technologies applying SbD to the four industrial processes respectively.
Fields of science
Keywords
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
LS2 9JT Leeds
United Kingdom
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Participants (20)
80686 Munchen
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B15 2TT Birmingham
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20520 Turku
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
2027 Kjeller
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157 80 ATHINA
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1070 Nicosia
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
PIRAEUS
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08018 Barcelona
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
33600 Pessac
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144 51 METAMORFOSIS
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
03680 Kiev
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
8010 Graz
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1000 Sofia
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Participation ended
1050 Bruxelles / Brussel
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1050 143 Lisboa
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
133-791 SEOUL
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305606 DAEJEON
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3086 La Trobe University
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Pokfulam
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1083 Ganshoren
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.