Project description DEENESFRITPL Substituting antibiotics in livestock Veterinary use of antimicrobials poses a threat to human health because of the possible transfer of resistant bacteria to people. AVANT aims at developing and testing the efficacy and sustainability of alternatives to antimicrobials for the management of pig enteritis, as this disease condition accounts for the majority of antimicrobials used in food animals. The alternatives under study include gut microbiome modulators, innovative medicines targeting the pathogen or the pig immune response, and feeding strategies for disease prevention. Based on the results of pre-clinical studies, including regulatory considerations, the efficacy of the most promising interventions will be assessed by farm trials. Mathematical modelling will be used to predict the effects of these interventions on reduction of antimicrobial use. Show the project objective Hide the project objective Objective Antimicrobial resistance in livestock is a public health threat due to the risk of zoonotic transmission to humans and its negative consequences on animal health and welfare when diseases cannot be treated. AVANT is a multi-actor inter-sectorial project aimed at developing alternatives to antimicrobials for the management of bacterial infections in pigs, especially diarrhoea during the weaning period, as the major indication for antimicrobial use in livestock in Europe. Antimicrobial treatment options for pigs are increasingly limited because of planned restrictions in the use of colistin and zinc, two current choices for treatment of post-weaning diarrhoea. The AVANT portfolio comprises a variety of alternatives for treatment or prevention of diarrhoea and/or respiratory infections, namely (i) gut-stabilizing interventions based on a symbiotic (pre- and probiotic) product and faecal microbiota transplantation; (ii) novel veterinary medicinal products containing bacteriophages and polymers for targeted treatment of enterotoxigenic E.coli infections; (iii) immuno-stimulating injectable and feed additive products, and (iv) alternative feeding strategies targeting sows and piglets. During pre-clinical studies, efficacy, toxicity, and mode of action of these interventions is tested, and their dosage and formulation optimized. The results and a survey for veterinarian-, farmer- and consumers perception of antimicrobial alternatives, will be used together with legal and economic considerations to select three interventions for large-scale farm trials, assessing clinical efficacy and impact on antimicrobial use. All steps are supported by regulatory advice for quick market entry post-project. Generated and existing data on antimicrobial use, pig demographics and projected consumption of pork, will be used in mathematical modelling to estimate the reduction in antimicrobial use that could be achieved by 2030 if the AVANT alternatives were widely adopted in pig production. Fields of science medical and health scienceshealth sciencespublic healthepidemiologyepidemics preventionmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsagricultural sciencesanimal and dairy sciencedomestic animalsanimal husbandrymedical and health scienceshealth sciencespublic healthepidemiologyzoonosismedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Keywords Pigs alternatives to antimicrobials gut stabilizers immunostimulants bacteriophages feed strategies farm trials diarrhoea respiratory disease animicrobial consumption Programme(s) H2020-EU.3.2. - SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy Main Programme H2020-EU.3.2.1.1. - Increasing production efficiency and coping with climate change, while ensuring sustainability and resilience Topic(s) SFS-11-2018-2019 - Anti-microbials and animal production Call for proposal H2020-SFS-2018-2020 See other projects for this call Sub call H2020-SFS-2019-1 Funding Scheme IA - Innovation action Coordinator KOBENHAVNS UNIVERSITET Net EU contribution € 2 254 125,00 Address Norregade 10 1165 Kobenhavn Denmark See on map Region Danmark Hovedstaden Byen København Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (13) Sort alphabetically Sort by Net EU contribution Expand all Collapse all BIOMIN HOLDING GMBH Austria Net EU contribution € 123 333,38 Address Erber campus 1 3131 Getzersdorf bei traismauer See on map Region Ostösterreich Niederösterreich Sankt Pölten Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 52 857,87 COOPERL INNOVATION S.A.S France Net EU contribution € 240 316,13 Address 7 rue de la jeannaie maroue zone industrielle 22400 Lamballe See on map Region Bretagne Bretagne Côtes-d’Armor Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 102 992,62 EASY-AGRICARE AS Denmark Net EU contribution € 31 981,25 Address Ostermollevej 32 7900 Nykobing See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Danmark Nordjylland Nordjylland Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 13 706,25 FEDERATION OF VETERINARIANS OF EUROPE Belgium Net EU contribution € 96 041,25 Address Rue victor oudart 7 1030 Schaerbeek See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 KLIFOVET AG Germany Net EU contribution € 260 181,25 Address Geyerspergerstrasse 27 80689 Munchen See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Bayern Oberbayern München, Kreisfreie Stadt Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 111 506,25 LABORATORIOS OVEJERO SA Spain Net EU contribution € 49 364,88 Address Ctra leon vilecha, 30 24192 Leon See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (ES) Castilla y León León Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 21 156,37 THE ROYAL VETERINARY COLLEGE United Kingdom Net EU contribution € 586 756,25 Address Royal college street NW1 OTU London See on map Region London Outer London — West and North West Barnet Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 RTDS - VEREIN ZUR FORDERUNG DER KOMMUNIKATION UND VERMITTLUNG VON FORSCHUNG, TECHNOLOGIE UND INNOVATION (RTDS VEREIN, ENGL. RTDS ASSOCIATION) Austria Net EU contribution € 357 791,25 Address Lerchengasse 25/2-3 1080 Wien See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ostösterreich Wien Wien Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SCHOTHORST FEED RESEARCH B.V. Netherlands Net EU contribution € 548 121,88 Address Meerkoetenweg 26 8200AM Lelystad See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Oost-Nederland Flevoland Flevoland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 234 909,37 LANDBRUG & FODEVARER F.M.B.A. Denmark Net EU contribution € 282 541,25 Address Axeltorv 3 1609 Kobenhavn See on map Region Danmark Hovedstaden Byen København Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland Net EU contribution € 260 420,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSIDAD COMPLUTENSE DE MADRID Spain Net EU contribution € 515 000,00 Address Avenida de seneca 2 28040 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 STICHTING WAGENINGEN RESEARCH Netherlands Net EU contribution € 393 931,25 Address Droevendaalsesteeg 4 6708 PB Wageningen See on map Region Oost-Nederland Gelderland Veluwe Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
