Descripción del proyecto
Sustituir los antibióticos en los alimentos para animales
Los antimicrobianos, como los antibióticos, se utilizan en veterinaria y medicina para matar o inhibir el crecimiento de los microorganismos. Por ejemplo, los criadores añaden antibióticos a los piensos para animales para acelerar el crecimiento de estos y evitar que enfermen. Sin embargo, el uso excesivo de antibióticos en la ganadería y la agricultura constituye una creciente amenaza para la salud humana. El proyecto AVANT, financiado con fondos europeos, está desarrollando alternativas a los antimicrobianos para la gestión de infecciones bacterianas en cerdos, que incluyen una intervención de estabilización intestinal basada en productos simbióticos y en el trasplante de la microbiota fecal, productos aditivos de los piensos y estrategias de alimentación alternativas dirigidas a cerdas y lechones. Si la industria de producción porcina adopta estas prácticas alternativas, se utilizarán herramientas de modelización matemática para estimar la reducción en el uso de antimicrobianos para 2030.
Objetivo
Antimicrobial resistance in livestock is a public health threat due to the risk of zoonotic transmission to humans and its negative consequences on animal health and welfare when diseases cannot be treated. AVANT is a multi-actor inter-sectorial project aimed at developing alternatives to antimicrobials for the management of bacterial infections in pigs, especially diarrhoea during the weaning period, as the major indication for antimicrobial use in livestock in Europe. Antimicrobial treatment options for pigs are increasingly limited because of planned restrictions in the use of colistin and zinc, two current choices for treatment of post-weaning diarrhoea. The AVANT portfolio comprises a variety of alternatives for treatment or prevention of diarrhoea and/or respiratory infections, namely (i) gut-stabilizing interventions based on a symbiotic (pre- and probiotic) product and faecal microbiota transplantation; (ii) novel veterinary medicinal products containing bacteriophages and polymers for targeted treatment of enterotoxigenic E.coli infections; (iii) immuno-stimulating injectable and feed additive products, and (iv) alternative feeding strategies targeting sows and piglets. During pre-clinical studies, efficacy, toxicity, and mode of action of these interventions is tested, and their dosage and formulation optimized. The results and a survey for veterinarian-, farmer- and consumers perception of antimicrobial alternatives, will be used together with legal and economic considerations to select three interventions for large-scale farm trials, assessing clinical efficacy and impact on antimicrobial use. All steps are supported by regulatory advice for quick market entry post-project. Generated and existing data on antimicrobial use, pig demographics and projected consumption of pork, will be used in mathematical modelling to estimate the reduction in antimicrobial use that could be achieved by 2030 if the AVANT alternatives were widely adopted in pig production.
Ámbito científico
- medical and health scienceshealth sciencespublic healthepidemiologyepidemics prevention
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- agricultural sciencesanimal and dairy sciencedomestic animalsanimal husbandry
- medical and health scienceshealth sciencespublic healthepidemiologyzoonosis
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-SFS-2019-1
Régimen de financiación
IA - Innovation actionCoordinador
1165 Kobenhavn
Dinamarca