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Non-invasive dynamic neural control by laser-based technology

Deliverables

Communication Plan

Communication plan comprising detailed and specific communications actions for the NEUROPA project, key messages relevant to the NEUROPA project to be communicated by the consortium, a press release template for NEUROPA, a NEUROPA presentation template including key slides on the project, consortium and appropriate acknowledgements. A NEUROPA logo for branding purposes, brochure, newsletter template, NEUROPA Twitter and NEUROPA LinkedIn account details.

Web-site developed

NEUROPA logo designed and web-site developed and launched with key messages and overview of the project and consortium.

Optimal opsin/phytochromes for modulation of neural activity using AAV

Optimal opsin / phytochrome delivery will be achieved using local delivery of naturally occuring AAV serotypes designed to target neural cells in brain circuits by use of specific promoters

Compact NIR laser for brain cortex blood flow monitoring system

Characterisation results for a compact nearinfrared laser of specifcation suitable for brain cortex blood flow monitoring using the diffuse wave spectormetery technique

USP laser 1000-1700nm

The achieved performance specification for a compact ultrashort pulsed laser system emitting in 1000 1700 nm spectrum range and average output power up to 500mW

Two-photon opsin/phytochrome activation and deactivation - Intermediate Report

Intermediate report on the achieved results of experiments on two-photon activation and deactivation of opsins/phytochromes

Scientific/Technical Review meeting documents - 1

ScientificTechnical Review P1 with expert reviewers

Initial National and European press releases

Press release describing in a public accessible way the project aims and objectives targeting publication in National and European press releases

Optimal phytochrome delivery system

Identification of optimal novel noninvasive Adeno Associated Virus delivered phytochrome system in mice for brain regionselective expression of opsinsphytochromes targeted to be used for further analysis using NIR laser excitation

Data Management Plan

Data Management Plan consitent with the published requirements including type of data to be generated, plans for management of data and provisions for open access publishing of data.

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Publications

Diagnosis of Skin Vascular Complications Revealed by Time-Frequency Analysis and Laser Doppler Spectrum Decomposition

Author(s): Evgeny Zherebtsov, Igor Kozlov, Viktor Dremin, Alexander Bykov, Andrey Dunaev, Igor Meglinski
Published in: IEEE Transactions in Biomedical Engineering, 2022, ISSN 0018-9294
Publisher: IEEE
DOI: 10.1109/tbme.2022.3181126

Dynamics of cerebral cortex blood flow and tissue abnormalities induced by acute respiratory disorders

Author(s): G.A. Piavchenko; V.V. Dremin; I.O. Kozlov; D.D. Stavtsev; S.L. Kuznetsov; A.V. Dunaev; I.V. Meglinski
Published in: Proc. SPIE 11919, Translational Biophotonics: Diagnostics and Therapeutics, 119190X, 2021, ISSN 1996-756X
Publisher: Society of Photo-Optical Instrumentation Engineers (SPIE)
DOI: 10.1117/12.2614597

Low-cost fabrication of PPIX liquid phantoms for use in fluorescence Measurements

Author(s): Valery Shupletsov*, Margarita Mikenkina, Evgeny Zherebtsov, Viktor Dremin, Alexander Bykov, Elena Potapova, Andrey Dunaev, Igor Meglinski
Published in: Proceedings Volume 12192, Optical Technologies for Biology and Medicine;, 1996756X, 2022, ISSN 1996-756X
Publisher: Society of Photo-Optical Instrumentation Engineers (SPIE)
DOI: 10.1117/12.2626389

Two-photon conversion of a bacterial phytochrome

Author(s): Serge G. Sokolovski,1 Evgeny A. Zherebtsov,2,3 Rajiv K. Kar,4 David Golonka,5 Robert Stabel,5 Nikolai B. Chichkov,1 Andrei Gorodetsky,6,7,8 Igor Schapiro,4 Andreas Möglich,5,∗ and Edik U. Rafailov1,∗
Published in: Biophyscial Journal, 00063495, 2021, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2021.01.028

M2 Cortex-Dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington's

Author(s): Sara Fernández-García, Sara Conde-Berriozabal, Esther García-García, Clara Gort-Paniello, David Bernal-Casas, Gerardo García-Díaz Barriga, Javier López-Gil, Emma Muñoz-Moreno, Guadalupe Soria, Leticia Campa, Francesc Artigas, Manuel José Rodríguez, Jordi Alberch and Mercè Masana (2020
Published in: eLife, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.57017.

Additional file 8 of Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington’s disease

Author(s): S. Fernández-García; J. G. Orlandi; G. A. García-Díaz Barriga; M. J. Rodríguez; M. Masana; J. Soriano; Alberch, J.
Published in: BMC Biology, 17417007, 2020, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.6084/m9.figshare.12386429.v1

Impairments of cerebral blood flow microcirculation in rats brought on by cardiac cessation and respiratory arrest

Author(s): Gennadii Piavchenko, Igor Kozlov, Viktor Dremin, Dmitry Stavtsev, Evgeniya Seryogina, Ksenia Kandurova, Valery Shupletsov, Konstantin Lapin, Alexander Alekseyev, Sergey Kuznetsov, Alexander Bykov, Andrey Dunaev, Igor Meglinski
Published in: Journal of Biophotonics, 1864063X, 2021, ISSN 1864-063X
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.202100216

Unraveling the Spatiotemporal Distribution of VPS13A in the Mouse Brain

Author(s): Esther García-García,1,2,3 Nerea Chaparro-Cabanillas,1 Albert Coll-Manzano,1,2 Maria Carreras-Caballé,1 Albert Giralt,1,2 Daniel Del Toro,1,2,3 Jordi Alberch,1,2,3,4 Mercè Masana,1,2,3,*† and Manuel J. Rodríguez1,
Published in: International Journal of Molecular Science, 14220067, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222313018

Optogenetic Control of Bacterial Expression by Red Light

Author(s): Elina Multamäki, Andrés García de Fuentes, Oleksii Sieryi, Alexander Bykov, Uwe Gerken, Américo Tavares Ranzani, Jürgen Köhler, Igor Meglinski, Andreas Möglich*, and Heikki Takala*
Published in: ACS Synthetic Biology, 21615063, 2022, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.1021/acssynbio.2c00259