Deliverables
System test results demonstrating the dynamic control of brain activity in murine models using the noninvasive hemodynamics feedback
Optimal opsin/phytochromes for modulation of neural activity using AAVOptimal opsin / phytochrome delivery will be achieved using local delivery of naturally occuring AAV serotypes designed to target neural cells in brain circuits by use of specific promoters
Compact NIR laser for brain cortex blood flow monitoring systemCharacterisation results for a compact nearinfrared laser of specifcation suitable for brain cortex blood flow monitoring using the diffuse wave spectormetery technique
USP laser 1000-1700nmThe achieved performance specification for a compact ultrashort pulsed laser system emitting in 1000 1700 nm spectrum range and average output power up to 500mW
Two-photon opsin/phytochrome activation and deactivation - Intermediate ReportIntermediate report on the achieved results of experiments on two-photon activation and deactivation of opsins/phytochromes
Two-photon opsin/phytochrome activation and deactivation - 2Final Report on assessment of novel laser sources on the ability to activate and deactivate twophoton opsinsphytochromes using a short pulse laser at 1000 1700nm wavelenght
Scientific/Technical Review meeting documents - 1ScientificTechnical Review P1 with expert reviewers
Initial National and European press releasesPress release describing in a public accessible way the project aims and objectives targeting publication in National and European press releases
Optimal phytochrome delivery systemIdentification of optimal novel noninvasive Adeno Associated Virus delivered phytochrome system in mice for brain regionselective expression of opsinsphytochromes targeted to be used for further analysis using NIR laser excitation
Communication plan comprising detailed and specific communications actions for the NEUROPA project, key messages relevant to the NEUROPA project to be communicated by the consortium, a press release template for NEUROPA, a NEUROPA presentation template including key slides on the project, consortium and appropriate acknowledgements. A NEUROPA logo for branding purposes, brochure, newsletter template, NEUROPA Twitter and NEUROPA LinkedIn account details.
Web-site developedNEUROPA logo designed and web-site developed and launched with key messages and overview of the project and consortium.
Data Management Plan consitent with the published requirements including type of data to be generated, plans for management of data and provisions for open access publishing of data.
Publications
Author(s):
Evgeny Zherebtsov, Igor Kozlov, Viktor Dremin, Alexander Bykov, Andrey Dunaev, Igor Meglinski
Published in:
IEEE Transactions in Biomedical Engineering, 2022, ISSN 0018-9294
Publisher:
IEEE
DOI:
10.1109/tbme.2022.3181126
Author(s):
Valerii V. Shupletsov; Margarita Mikenkina; Evgeny Zherebtsov; Viktor Dremin; Alexander Bykov; Elena Potapova; Andrey Dunaev; Igor Meglinski
Published in:
Optical Technologies for Biology and Medicine, Issue Proceedings Volume 12192, 2021, ISSN 1605-7422
Publisher:
SPIE
DOI:
10.1117/12.2626389
Author(s):
Robert Ohlendorf
Andreas Möglich
Published in:
Frontiers in Bioengineering and Biotechnology, 2022, Page(s) Volume 10 - 2022, ISSN 2296-4185
Publisher:
Frontiers
DOI:
10.3389/fbioe.2022.1029403
Author(s):
Serge G. Sokolovski,1 Evgeny A. Zherebtsov,2,3 Rajiv K. Kar,4 David Golonka,5 Robert Stabel,5 Nikolai B. Chichkov,1 Andrei Gorodetsky,6,7,8 Igor Schapiro,4 Andreas Möglich,5,∗ and Edik U. Rafailov1,∗
Published in:
Biophyscial Journal, Issue 00063495, 2021, ISSN 0006-3495
Publisher:
Biophysical Society
DOI:
10.1016/j.bpj.2021.01.028
Author(s):
Esther Garcia-Garcia et al
Published in:
Neurobiology of Disease, Issue Volume 187, 2023, ISSN 0022-3034
Publisher:
Elsevier
DOI:
10.1016/j.nbd.2023.106292
Author(s):
Sara Fernández-García, Sara Conde-Berriozabal, Esther García-García, Clara Gort-Paniello, David Bernal-Casas, Gerardo García-Díaz Barriga, Javier López-Gil, Emma Muñoz-Moreno, Guadalupe Soria, Leticia Campa, Francesc Artigas, Manuel José Rodríguez, Jordi Alberch and Mercè Masana (2020
Published in:
eLife, 2020, ISSN 2050-084X
Publisher:
eLife Sciences Publications
DOI:
10.7554/elife.57017.
Author(s):
Fernandez-Garcia et al
Published in:
BMC Biology, Issue BMC Biology 18 Article number 58, 2020, ISSN 1741-7007
Publisher:
BioMed Central
DOI:
10.1186/s12915-020-00794-4
Author(s):
Diana Galiakhmetova, Viktor Dremin, Aleksandr Koviarov, Dmitrii Stoliarov, Neville Ngum, Raghavan Chinnambedu Murugesan, Rheinallt Parri, Sergei Sokolovski, Edik Rafailov
Published in:
Biophotonics, 2022, Page(s) Volume 29 Issue 4, ISSN 1077-260X
Publisher:
Institute of Electrical and Electronics Engineers
DOI:
10.1109/jstqe.2022.3214788
Author(s):
Gennadii Piavchenko, Igor Kozlov, Viktor Dremin, Dmitry Stavtsev, Evgeniya Seryogina, Ksenia Kandurova, Valery Shupletsov, Konstantin Lapin, Alexander Alekseyev, Sergey Kuznetsov, Alexander Bykov, Andrey Dunaev, Igor Meglinski
Published in:
Journal of Biophotonics, Issue 1864063X, 2021, ISSN 1864-063X
Publisher:
Wiley - VCH Verlag GmbH & CO. KGaA
DOI:
10.1002/jbio.202100216
Author(s):
Anett Huak, Tamas Letoha
Published in:
International Journal of Molecular Sciences, 2023, Page(s) Volume 24 Issue 4, ISSN 1661-6596
Publisher:
MDPI
DOI:
10.3390/ijms24043141
Author(s):
Elena Lopez-Terrones, Merce Masana, Maurizio S. Riga
Published in:
International Journal of Molecular Sciences, 2023, Page(s) Volume 24 Issue 5, ISSN 1661-6596
Publisher:
MDPI
DOI:
10.3390/ijms24054891
Author(s):
A. Sdobnov, G. Pyavchenko, A. Bykov, and I. Meglinski.
Published in:
Laser & Photonics Review, Issue 27th November 2023, 2023, ISSN 1863-8899
Publisher:
Wiley
DOI:
10.1002/lpor.202300494
Author(s):
Sara Conde-Berriozabal, Lia García-Gilabert, Esther García-García, Laia Sitjà-Roqueta, Xavier López-Gil, Emma Muñoz-Moreno, Mehdi Boutagouga Boudjadja, Guadalupe Soria, Manuel J Rodríguez, Jordi Alberch and Mercè Masana
Published in:
Journal of Neuroscience, 2023, Page(s) 3 May 2023, ISSN 1529-2401
Publisher:
Society of Neuroscience
DOI:
10.1523/jneurosci.1172-22.2023
Author(s):
Esther García-García,1,2,3 Nerea Chaparro-Cabanillas,1 Albert Coll-Manzano,1,2 Maria Carreras-Caballé,1 Albert Giralt,1,2 Daniel Del Toro,1,2,3 Jordi Alberch,1,2,3,4 Mercè Masana,1,2,3,*† and Manuel J. Rodríguez1,
Published in:
International Journal of Molecular Science, Issue 14220067, 2021, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms222313018
Author(s):
Stoliarov et al
Published in:
Optics Express, Issue Vol 31 Issue 26 pp 43427-43437, 2023, ISSN 1094-4087
Publisher:
Optical Society of America
DOI:
10.1364/oe.510017
Author(s):
Elina Multamäki, Andrés García de Fuentes, Oleksii Sieryi, Alexander Bykov, Uwe Gerken, Américo Tavares Ranzani, Jürgen Köhler, Igor Meglinski, Andreas Möglich*, and Heikki Takala*
Published in:
ACS Synthetic Biology, Issue 21615063, 2022, ISSN 2161-5063
Publisher:
American Chemical Society
DOI:
10.1021/acssynbio.2c00259
Author(s):
Qianzhao Xu; Arend Vogt; Fabian Frechen; Chengwei Yi; Melike Küçükerden; Neville Ngum; Laia Sitjà-Roqueta; Andreas Greiner; Rhein Parri; Mercè Masana; Nikolaus Wenger; Dagmar Wachten; Andreas Möglich
Published in:
Journal of Molecular Biology, Issue 168257, 2023, ISSN 1089-8638
Publisher:
Elsevier
DOI:
10.2139/ssrn.4428546
Author(s):
John B. Butcher; Robert E. Sims; Neville M. Ngum; Amjad H. Bazzari; Stuart I. Jenkins; Marianne King; Eric J. Hill; David A. Nagel; Kevin Fox; H. Rheinallt Parri; Stanislaw Glazewski
Published in:
Frontiers in Cellular Neuroscience, Issue 28, 2022, ISSN 1662-5102
Publisher:
Frontiers Research Foundation
DOI:
10.3389/fncel.2022.905285
Author(s):
Emilia A. Zin; Bilge E. Ozturk; Deniz Dalkara; Leah C. Byrne
Published in:
Cold Spring Harbor Prespectives in Medicine, Issue March 27th 2023, 2023, ISSN 2157-1422
Publisher:
Cold Spring Harbor
DOI:
10.1101/cshperspect.a041291
Author(s):
Julia Solana-Balaguer, Genís Campoy-Campos, Núria Martín-Flores, Leticia Pérez-Sisqués, Laia Sitjà-Roqueta, Melike Kucukerden, Ana Gámez-Valero, Albert Coll-Manzano, Eulàlia Martí, Esther Pérez-Navarro, Jordi Alberch, Jordi Soriano, Mercè Masana, Cristina Malagelada
Published in:
Journal of Extracellular Vesicles, 2023, Page(s) Volume 12, Issue 9, ISSN 2001-3078
Publisher:
Wiley
DOI:
10.1002/jev2.12355
Intellectual Property Rights
Application/Publication number:
20
21000011
Date:
2021-07-21
Applicant(s):
PHARMACOIDEA FEJLESZTO ES SZOLGALTATO KFT
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