Non-invasive dynamic neural control by laser-based technology

Rezultaty

System test of non-invasive hemodynamics feedback control of brain activity in vivo

System test results demonstrating the dynamic control of brain activity in murine models using the noninvasive hemodynamics feedback

Optimal opsin/phytochromes for modulation of neural activity using AAV

Optimal opsin / phytochrome delivery will be achieved using local delivery of naturally occuring AAV serotypes designed to target neural cells in brain circuits by use of specific promoters

Compact NIR laser for brain cortex blood flow monitoring system

Characterisation results for a compact nearinfrared laser of specifcation suitable for brain cortex blood flow monitoring using the diffuse wave spectormetery technique

USP laser 1000-1700nm

The achieved performance specification for a compact ultrashort pulsed laser system emitting in 1000 1700 nm spectrum range and average output power up to 500mW

Two-photon opsin/phytochrome activation and deactivation - Intermediate Report

Intermediate report on the achieved results of experiments on two-photon activation and deactivation of opsins/phytochromes

Two-photon opsin/phytochrome activation and deactivation - 2

Final Report on assessment of novel laser sources on the ability to activate and deactivate twophoton opsinsphytochromes using a short pulse laser at 1000 1700nm wavelenght

Scientific/Technical Review meeting documents - 1

ScientificTechnical Review P1 with expert reviewers

Initial National and European press releases

Press release describing in a public accessible way the project aims and objectives targeting publication in National and European press releases

Optimal phytochrome delivery system

Identification of optimal novel noninvasive Adeno Associated Virus delivered phytochrome system in mice for brain regionselective expression of opsinsphytochromes targeted to be used for further analysis using NIR laser excitation

Communication Plan

Communication plan comprising detailed and specific communications actions for the NEUROPA project, key messages relevant to the NEUROPA project to be communicated by the consortium, a press release template for NEUROPA, a NEUROPA presentation template including key slides on the project, consortium and appropriate acknowledgements. A NEUROPA logo for branding purposes, brochure, newsletter template, NEUROPA Twitter and NEUROPA LinkedIn account details.

Web-site developed

NEUROPA logo designed and web-site developed and launched with key messages and overview of the project and consortium.

Data Management Plan

Data Management Plan consitent with the published requirements including type of data to be generated, plans for management of data and provisions for open access publishing of data.

Publikacje

Diagnosis of Skin Vascular Complications Revealed by Time-Frequency Analysis and Laser Doppler Spectrum Decomposition

Autorzy: Evgeny Zherebtsov, Igor Kozlov, Viktor Dremin, Alexander Bykov, Andrey Dunaev, Igor Meglinski
Opublikowane w: IEEE Transactions in Biomedical Engineering, 2022, ISSN 0018-9294
Wydawca: IEEE
DOI: 10.1109/tbme.2022.3181126

Dynamics of cerebral cortex blood flow and tissue abnormalities induced by acute respiratory disorders

Autorzy: G.A. Piavchenko; V.V. Dremin; I.O. Kozlov; D.D. Stavtsev; S.L. Kuznetsov; A.V. Dunaev; I.V. Meglinski
Opublikowane w: Proc. SPIE 11919, Translational Biophotonics: Diagnostics and Therapeutics, 119190X, 2021, ISSN 1996-756X
Wydawca: Society of Photo-Optical Instrumentation Engineers (SPIE)
DOI: 10.1117/12.2614597

Low-cost fabrication of PPIX liquid phantoms for use in fluorescence measurements

Autorzy: Valerii V. Shupletsov; Margarita Mikenkina; Evgeny Zherebtsov; Viktor Dremin; Alexander Bykov; Elena Potapova; Andrey Dunaev; Igor Meglinski
Opublikowane w: Optical Technologies for Biology and Medicine, Numer Proceedings Volume 12192, 2021, ISSN 1605-7422
Wydawca: SPIE
DOI: 10.1117/12.2626389

Low-cost fabrication of PPIX liquid phantoms for use in fluorescence Measurements

Autorzy: Valery Shupletsov*, Margarita Mikenkina, Evgeny Zherebtsov, Viktor Dremin, Alexander Bykov, Elena Potapova, Andrey Dunaev, Igor Meglinski
Opublikowane w: Proceedings Volume 12192, Optical Technologies for Biology and Medicine;, Numer 1996756X, 2022, ISSN 1996-756X
Wydawca: Society of Photo-Optical Instrumentation Engineers (SPIE)
DOI: 10.1117/12.2626389

Light-regulated gene expression in Bacteria: Fundamentals, advances, and perspectives

Autorzy: Robert Ohlendorf Andreas Möglich
Opublikowane w: Frontiers in Bioengineering and Biotechnology, 2022, Strona(/y) Volume 10 - 2022, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2022.1029403

Two-photon conversion of a bacterial phytochrome

Autorzy: Serge G. Sokolovski,1 Evgeny A. Zherebtsov,2,3 Rajiv K. Kar,4 David Golonka,5 Robert Stabel,5 Nikolai B. Chichkov,1 Andrei Gorodetsky,6,7,8 Igor Schapiro,4 Andreas Möglich,5,∗ and Edik U. Rafailov1,∗
Opublikowane w: Biophyscial Journal, Numer 00063495, 2021, ISSN 0006-3495
Wydawca: Biophysical Society
DOI: 10.1016/j.bpj.2021.01.028

VPS13A knockdown impairs corticostriatal synaptic plasticity and locomotor behavior in a new mouse model of chorea-acanthocytosis

Autorzy: Esther Garcia-Garcia et al
Opublikowane w: Neurobiology of Disease, Numer Volume 187, 2023, ISSN 0022-3034
Wydawca: Elsevier
DOI: 10.1016/j.nbd.2023.106292

M2 Cortex-Dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington's

Autorzy: Sara Fernández-García, Sara Conde-Berriozabal, Esther García-García, Clara Gort-Paniello, David Bernal-Casas, Gerardo García-Díaz Barriga, Javier López-Gil, Emma Muñoz-Moreno, Guadalupe Soria, Leticia Campa, Francesc Artigas, Manuel José Rodríguez, Jordi Alberch and Mercè Masana (2020
Opublikowane w: eLife, 2020, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.57017.

Additional file 8 of Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington’s disease

Autorzy: S. Fernández-García; J. G. Orlandi; G. A. García-Díaz Barriga; M. J. Rodríguez; M. Masana; J. Soriano; Alberch, J.
Opublikowane w: BMC Biology, Numer 17417007, 2020, ISSN 1741-7007
Wydawca: BioMed Central
DOI: 10.6084/m9.figshare.12386429.v1

Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington’s disease

Autorzy: Fernandez-Garcia et al
Opublikowane w: BMC Biology, Numer BMC Biology 18 Article number 58, 2020, ISSN 1741-7007
Wydawca: BioMed Central
DOI: 10.1186/s12915-020-00794-4

Ultra-short laser pulses propagation through mouse head tissues: experimental and computational study”

Autorzy: Diana Galiakhmetova, Viktor Dremin, Aleksandr Koviarov, Dmitrii Stoliarov, Neville Ngum, Raghavan Chinnambedu Murugesan, Rheinallt Parri, Sergei Sokolovski, Edik Rafailov
Opublikowane w: Biophotonics, 2022, Strona(/y) Volume 29 Numer 4, ISSN 1077-260X
Wydawca: Institute of Electrical and Electronics Engineers
DOI: 10.1109/jstqe.2022.3214788

Impairments of cerebral blood flow microcirculation in rats brought on by cardiac cessation and respiratory arrest

Autorzy: Gennadii Piavchenko, Igor Kozlov, Viktor Dremin, Dmitry Stavtsev, Evgeniya Seryogina, Ksenia Kandurova, Valery Shupletsov, Konstantin Lapin, Alexander Alekseyev, Sergey Kuznetsov, Alexander Bykov, Andrey Dunaev, Igor Meglinski
Opublikowane w: Journal of Biophotonics, Numer 1864063X, 2021, ISSN 1864-063X
Wydawca: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.202100216

Syndecan-4 Mediates the Cellular Entry of Adeno-Associated Virus 9

Autorzy: Anett Huak, Tamas Letoha
Opublikowane w: International Journal of Molecular Sciences, 2023, Strona(/y) Volume 24 Numer 4, ISSN 1661-6596
Wydawca: MDPI
DOI: 10.3390/ijms24043141

Differential Modulation of Dorsal Raphe Serotonergic Activity in Rat Brain by the Infralimbic and Prelimbic Cortices

Autorzy: Elena Lopez-Terrones, Merce Masana, Maurizio S. Riga
Opublikowane w: International Journal of Molecular Sciences, 2023, Strona(/y) Volume 24 Numer 5, ISSN 1661-6596
Wydawca: MDPI
DOI: 10.3390/ijms24054891

Advances in Dynamic Light Scattering imaging of blood flow and blood microcirculation

Autorzy: A. Sdobnov, G. Pyavchenko, A. Bykov, and I. Meglinski.
Opublikowane w: Laser & Photonics Review, Numer 27th November 2023, 2023, ISSN 1863-8899
Wydawca: Wiley
DOI: 10.1002/lpor.202300494

M2 Cortex Circuitry and Sensory-Induced Behavioral Alterations in Huntington's Disease: Role of Superior Colliculus

Autorzy: Sara Conde-Berriozabal, Lia García-Gilabert, Esther García-García, Laia Sitjà-Roqueta, Xavier López-Gil, Emma Muñoz-Moreno, Mehdi Boutagouga Boudjadja, Guadalupe Soria, Manuel J Rodríguez, Jordi Alberch and Mercè Masana
Opublikowane w: Journal of Neuroscience, 2023, Strona(/y) 3 May 2023, ISSN 1529-2401
Wydawca: Society of Neuroscience
DOI: 10.1523/jneurosci.1172-22.2023

Unraveling the Spatiotemporal Distribution of VPS13A in the Mouse Brain

Autorzy: Esther García-García,1,2,3 Nerea Chaparro-Cabanillas,1 Albert Coll-Manzano,1,2 Maria Carreras-Caballé,1 Albert Giralt,1,2 Daniel Del Toro,1,2,3 Jordi Alberch,1,2,3,4 Mercè Masana,1,2,3,*† and Manuel J. Rodríguez1,
Opublikowane w: International Journal of Molecular Science, Numer 14220067, 2021, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222313018

Gain-managed nonlinear amplification of ultra-long mode-locked fiber laser

Autorzy: Stoliarov et al
Opublikowane w: Optics Express, Numer Vol 31 Numer 26 pp 43427-43437, 2023, ISSN 1094-4087
Wydawca: Optical Society of America
DOI: 10.1364/oe.510017

Optogenetic Control of Bacterial Expression by Red Light

Autorzy: Elina Multamäki, Andrés García de Fuentes, Oleksii Sieryi, Alexander Bykov, Uwe Gerken, Américo Tavares Ranzani, Jürgen Köhler, Igor Meglinski, Andreas Möglich*, and Heikki Takala*
Opublikowane w: ACS Synthetic Biology, Numer 21615063, 2022, ISSN 2161-5063
Wydawca: American Chemical Society
DOI: 10.1021/acssynbio.2c00259

Engineering Bacteriophytochrome-Coupled Photoactivated Adenylyl Cyclases for Enhanced Optogenetic Camp Modulation

Autorzy: Qianzhao Xu; Arend Vogt; Fabian Frechen; Chengwei Yi; Melike Küçükerden; Neville Ngum; Laia Sitjà-Roqueta; Andreas Greiner; Rhein Parri; Mercè Masana; Nikolaus Wenger; Dagmar Wachten; Andreas Möglich
Opublikowane w: Journal of Molecular Biology, Numer 168257, 2023, ISSN 1089-8638
Wydawca: Elsevier
DOI: 10.2139/ssrn.4428546

A requirement for astrocyte IP3R2 signaling for whisker experience-dependent depression and homeostatic upregulation in the mouse barrel cortex

Autorzy: John B. Butcher; Robert E. Sims; Neville M. Ngum; Amjad H. Bazzari; Stuart I. Jenkins; Marianne King; Eric J. Hill; David A. Nagel; Kevin Fox; H. Rheinallt Parri; Stanislaw Glazewski
Opublikowane w: Frontiers in Cellular Neuroscience, Numer 28, 2022, ISSN 1662-5102
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fncel.2022.905285

Developing New Vectors for Retinal Gene Therapy

Autorzy: Emilia A. Zin; Bilge E. Ozturk; Deniz Dalkara; Leah C. Byrne
Opublikowane w: Cold Spring Harbor Prespectives in Medicine, Numer March 27th 2023, 2023, ISSN 2157-1422
Wydawca: Cold Spring Harbor
DOI: 10.1101/cshperspect.a041291

Neuron-derived extracellular vesicles contain synaptic proteins, promote spine formation, activate TrkB-mediated signalling and preserve neuronal complexity

Autorzy: Julia Solana-Balaguer, Genís Campoy-Campos, Núria Martín-Flores, Leticia Pérez-Sisqués, Laia Sitjà-Roqueta, Melike Kucukerden, Ana Gámez-Valero, Albert Coll-Manzano, Eulàlia Martí, Esther Pérez-Navarro, Jordi Alberch, Jordi Soriano, Mercè Masana, Cristina Malagelada
Opublikowane w: Journal of Extracellular Vesicles, 2023, Strona(/y) Volume 12, Numer 9, ISSN 2001-3078
Wydawca: Wiley
DOI: 10.1002/jev2.12355

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