Non-invasive dynamic neural control by laser-based technology

Livrables

System test of non-invasive hemodynamics feedback control of brain activity in vivo

System test results demonstrating the dynamic control of brain activity in murine models using the noninvasive hemodynamics feedback

Optimal opsin/phytochromes for modulation of neural activity using AAV

Optimal opsin / phytochrome delivery will be achieved using local delivery of naturally occuring AAV serotypes designed to target neural cells in brain circuits by use of specific promoters

Compact NIR laser for brain cortex blood flow monitoring system

Characterisation results for a compact nearinfrared laser of specifcation suitable for brain cortex blood flow monitoring using the diffuse wave spectormetery technique

USP laser 1000-1700nm

The achieved performance specification for a compact ultrashort pulsed laser system emitting in 1000 1700 nm spectrum range and average output power up to 500mW

Two-photon opsin/phytochrome activation and deactivation - Intermediate Report

Intermediate report on the achieved results of experiments on two-photon activation and deactivation of opsins/phytochromes

Two-photon opsin/phytochrome activation and deactivation - 2

Final Report on assessment of novel laser sources on the ability to activate and deactivate twophoton opsinsphytochromes using a short pulse laser at 1000 1700nm wavelenght

Scientific/Technical Review meeting documents - 1

ScientificTechnical Review P1 with expert reviewers

Initial National and European press releases

Press release describing in a public accessible way the project aims and objectives targeting publication in National and European press releases

Optimal phytochrome delivery system

Identification of optimal novel noninvasive Adeno Associated Virus delivered phytochrome system in mice for brain regionselective expression of opsinsphytochromes targeted to be used for further analysis using NIR laser excitation

Communication Plan

Communication plan comprising detailed and specific communications actions for the NEUROPA project, key messages relevant to the NEUROPA project to be communicated by the consortium, a press release template for NEUROPA, a NEUROPA presentation template including key slides on the project, consortium and appropriate acknowledgements. A NEUROPA logo for branding purposes, brochure, newsletter template, NEUROPA Twitter and NEUROPA LinkedIn account details.

Web-site developed

NEUROPA logo designed and web-site developed and launched with key messages and overview of the project and consortium.

Data Management Plan

Data Management Plan consitent with the published requirements including type of data to be generated, plans for management of data and provisions for open access publishing of data.

Publications

Diagnosis of Skin Vascular Complications Revealed by Time-Frequency Analysis and Laser Doppler Spectrum Decomposition

Auteurs: Evgeny Zherebtsov, Igor Kozlov, Viktor Dremin, Alexander Bykov, Andrey Dunaev, Igor Meglinski
Publié dans: IEEE Transactions in Biomedical Engineering, 2022, ISSN 0018-9294
Éditeur: IEEE
DOI: 10.1109/tbme.2022.3181126

Low-cost fabrication of PPIX liquid phantoms for use in fluorescence measurements

Auteurs: Valerii V. Shupletsov; Margarita Mikenkina; Evgeny Zherebtsov; Viktor Dremin; Alexander Bykov; Elena Potapova; Andrey Dunaev; Igor Meglinski
Publié dans: Optical Technologies for Biology and Medicine, Numéro Proceedings Volume 12192, 2021, ISSN 1605-7422
Éditeur: SPIE
DOI: 10.1117/12.2626389

Light-regulated gene expression in Bacteria: Fundamentals, advances, and perspectives

Auteurs: Robert Ohlendorf Andreas Möglich
Publié dans: Frontiers in Bioengineering and Biotechnology, 2022, Page(s) Volume 10 - 2022, ISSN 2296-4185
Éditeur: Frontiers
DOI: 10.3389/fbioe.2022.1029403

Two-photon conversion of a bacterial phytochrome

Auteurs: Serge G. Sokolovski,1 Evgeny A. Zherebtsov,2,3 Rajiv K. Kar,4 David Golonka,5 Robert Stabel,5 Nikolai B. Chichkov,1 Andrei Gorodetsky,6,7,8 Igor Schapiro,4 Andreas Möglich,5,∗ and Edik U. Rafailov1,∗
Publié dans: Biophyscial Journal, Numéro 00063495, 2021, ISSN 0006-3495
Éditeur: Biophysical Society
DOI: 10.1016/j.bpj.2021.01.028

VPS13A knockdown impairs corticostriatal synaptic plasticity and locomotor behavior in a new mouse model of chorea-acanthocytosis

Auteurs: Esther Garcia-Garcia et al
Publié dans: Neurobiology of Disease, Numéro Volume 187, 2023, ISSN 0022-3034
Éditeur: Elsevier
DOI: 10.1016/j.nbd.2023.106292

M2 Cortex-Dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington's

Auteurs: Sara Fernández-García, Sara Conde-Berriozabal, Esther García-García, Clara Gort-Paniello, David Bernal-Casas, Gerardo García-Díaz Barriga, Javier López-Gil, Emma Muñoz-Moreno, Guadalupe Soria, Leticia Campa, Francesc Artigas, Manuel José Rodríguez, Jordi Alberch and Mercè Masana (2020
Publié dans: eLife, 2020, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.57017.

Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington’s disease

Auteurs: Fernandez-Garcia et al
Publié dans: BMC Biology, Numéro BMC Biology 18 Article number 58, 2020, ISSN 1741-7007
Éditeur: BioMed Central
DOI: 10.1186/s12915-020-00794-4

Ultra-short laser pulses propagation through mouse head tissues: experimental and computational study”

Auteurs: Diana Galiakhmetova, Viktor Dremin, Aleksandr Koviarov, Dmitrii Stoliarov, Neville Ngum, Raghavan Chinnambedu Murugesan, Rheinallt Parri, Sergei Sokolovski, Edik Rafailov
Publié dans: Biophotonics, 2022, Page(s) Volume 29 Numéro 4, ISSN 1077-260X
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/jstqe.2022.3214788

Impairments of cerebral blood flow microcirculation in rats brought on by cardiac cessation and respiratory arrest

Auteurs: Gennadii Piavchenko, Igor Kozlov, Viktor Dremin, Dmitry Stavtsev, Evgeniya Seryogina, Ksenia Kandurova, Valery Shupletsov, Konstantin Lapin, Alexander Alekseyev, Sergey Kuznetsov, Alexander Bykov, Andrey Dunaev, Igor Meglinski
Publié dans: Journal of Biophotonics, Numéro 1864063X, 2021, ISSN 1864-063X
Éditeur: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.202100216

Syndecan-4 Mediates the Cellular Entry of Adeno-Associated Virus 9

Auteurs: Anett Huak, Tamas Letoha
Publié dans: International Journal of Molecular Sciences, 2023, Page(s) Volume 24 Numéro 4, ISSN 1661-6596
Éditeur: MDPI
DOI: 10.3390/ijms24043141

Differential Modulation of Dorsal Raphe Serotonergic Activity in Rat Brain by the Infralimbic and Prelimbic Cortices

Auteurs: Elena Lopez-Terrones, Merce Masana, Maurizio S. Riga
Publié dans: International Journal of Molecular Sciences, 2023, Page(s) Volume 24 Numéro 5, ISSN 1661-6596
Éditeur: MDPI
DOI: 10.3390/ijms24054891

Advances in Dynamic Light Scattering imaging of blood flow and blood microcirculation

Auteurs: A. Sdobnov, G. Pyavchenko, A. Bykov, and I. Meglinski.
Publié dans: Laser & Photonics Review, Numéro 27th November 2023, 2023, ISSN 1863-8899
Éditeur: Wiley
DOI: 10.1002/lpor.202300494

M2 Cortex Circuitry and Sensory-Induced Behavioral Alterations in Huntington's Disease: Role of Superior Colliculus

Auteurs: Sara Conde-Berriozabal, Lia García-Gilabert, Esther García-García, Laia Sitjà-Roqueta, Xavier López-Gil, Emma Muñoz-Moreno, Mehdi Boutagouga Boudjadja, Guadalupe Soria, Manuel J Rodríguez, Jordi Alberch and Mercè Masana
Publié dans: Journal of Neuroscience, 2023, Page(s) 3 May 2023, ISSN 1529-2401
Éditeur: Society of Neuroscience
DOI: 10.1523/jneurosci.1172-22.2023

Unraveling the Spatiotemporal Distribution of VPS13A in the Mouse Brain

Auteurs: Esther García-García,1,2,3 Nerea Chaparro-Cabanillas,1 Albert Coll-Manzano,1,2 Maria Carreras-Caballé,1 Albert Giralt,1,2 Daniel Del Toro,1,2,3 Jordi Alberch,1,2,3,4 Mercè Masana,1,2,3,*† and Manuel J. Rodríguez1,
Publié dans: International Journal of Molecular Science, Numéro 14220067, 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222313018

Gain-managed nonlinear amplification of ultra-long mode-locked fiber laser

Auteurs: Stoliarov et al
Publié dans: Optics Express, Numéro Vol 31 Numéro 26 pp 43427-43437, 2023, ISSN 1094-4087
Éditeur: Optical Society of America
DOI: 10.1364/oe.510017

Optogenetic Control of Bacterial Expression by Red Light

Auteurs: Elina Multamäki, Andrés García de Fuentes, Oleksii Sieryi, Alexander Bykov, Uwe Gerken, Américo Tavares Ranzani, Jürgen Köhler, Igor Meglinski, Andreas Möglich*, and Heikki Takala*
Publié dans: ACS Synthetic Biology, Numéro 21615063, 2022, ISSN 2161-5063
Éditeur: American Chemical Society
DOI: 10.1021/acssynbio.2c00259

Engineering Bacteriophytochrome-Coupled Photoactivated Adenylyl Cyclases for Enhanced Optogenetic Camp Modulation

Auteurs: Qianzhao Xu; Arend Vogt; Fabian Frechen; Chengwei Yi; Melike Küçükerden; Neville Ngum; Laia Sitjà-Roqueta; Andreas Greiner; Rhein Parri; Mercè Masana; Nikolaus Wenger; Dagmar Wachten; Andreas Möglich
Publié dans: Journal of Molecular Biology, Numéro 168257, 2023, ISSN 1089-8638
Éditeur: Elsevier
DOI: 10.2139/ssrn.4428546

A requirement for astrocyte IP3R2 signaling for whisker experience-dependent depression and homeostatic upregulation in the mouse barrel cortex

Auteurs: John B. Butcher; Robert E. Sims; Neville M. Ngum; Amjad H. Bazzari; Stuart I. Jenkins; Marianne King; Eric J. Hill; David A. Nagel; Kevin Fox; H. Rheinallt Parri; Stanislaw Glazewski
Publié dans: Frontiers in Cellular Neuroscience, Numéro 28, 2022, ISSN 1662-5102
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fncel.2022.905285

Developing New Vectors for Retinal Gene Therapy

Auteurs: Emilia A. Zin; Bilge E. Ozturk; Deniz Dalkara; Leah C. Byrne
Publié dans: Cold Spring Harbor Prespectives in Medicine, Numéro March 27th 2023, 2023, ISSN 2157-1422
Éditeur: Cold Spring Harbor
DOI: 10.1101/cshperspect.a041291

Neuron-derived extracellular vesicles contain synaptic proteins, promote spine formation, activate TrkB-mediated signalling and preserve neuronal complexity

Auteurs: Julia Solana-Balaguer, Genís Campoy-Campos, Núria Martín-Flores, Leticia Pérez-Sisqués, Laia Sitjà-Roqueta, Melike Kucukerden, Ana Gámez-Valero, Albert Coll-Manzano, Eulàlia Martí, Esther Pérez-Navarro, Jordi Alberch, Jordi Soriano, Mercè Masana, Cristina Malagelada
Publié dans: Journal of Extracellular Vesicles, 2023, Page(s) Volume 12, Numéro 9, ISSN 2001-3078
Éditeur: Wiley
DOI: 10.1002/jev2.12355

Droits de propriété intellectuelle

A DIAGNOSTIC BLOOD TEST METHOD FOR THE DETECTION OF ALZHEIMER'S DISEASE

Numéro de demande/publication: 20 21000011
Date: 2021-07-21
Demandeur(s): PHARMACOIDEA FEJLESZTO ES SZOLGALTATO KFT

Livrables

Publications

Droits de propriété intellectuelle

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