Project description
Role of long, non-coding RNAs in gene regulation
Tens of thousands of loci in mammalian genomes produce long non-coding RNAs (lncRNAs): these transcripts with lengths exceeding 200 nucleotides are not translated into proteins. At present, only a small fraction of lncRNAs have been proved biologically relevant, despite accumulating evidence that most are likely to be functional. The EU-funded IncImpact project will employ an arsenal of modern tools (from molecular biology, computational biology, high-throughput screens, cell biology and mouse genetics) to uncover the functions of lncRNAs. The project will focus on three classes of lncRNAs regulating gene expression at a distance in cis position, affecting the activity of proximal promoters, or modulating the function of the proteins that regulate mRNAs post-transcriptionally. The research has potential to characterise new lncRNAs with similar modes of action and identify general principles underlying how lncRNA gene loci impact gene-regulatory networks and gene expression in mammalian cells.
Fields of science
Programme(s)
Funding Scheme
ERC-COG - Consolidator GrantHost institution
7610001 Rehovot
Israel
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Beneficiaries (1)
7610001 Rehovot
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