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Long noncoding RNAs: Impact on Gene Regulatory Networks

Project description

Role of long, non-coding RNAs in gene regulation

Tens of thousands of loci in mammalian genomes produce long non-coding RNAs (lncRNAs): these transcripts with lengths exceeding 200 nucleotides are not translated into proteins. At present, only a small fraction of lncRNAs have been proved biologically relevant, despite accumulating evidence that most are likely to be functional. The EU-funded IncImpact project will employ an arsenal of modern tools (from molecular biology, computational biology, high-throughput screens, cell biology and mouse genetics) to uncover the functions of lncRNAs. The project will focus on three classes of lncRNAs regulating gene expression at a distance in cis position, affecting the activity of proximal promoters, or modulating the function of the proteins that regulate mRNAs post-transcriptionally. The research has potential to characterise new lncRNAs with similar modes of action and identify general principles underlying how lncRNA gene loci impact gene-regulatory networks and gene expression in mammalian cells.

Host institution

WEIZMANN INSTITUTE OF SCIENCE
Net EU contribution
€ 2 000 000,00
Address
Herzl Street 234
7610001 Rehovot
Israel

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 000 000,00

Beneficiaries (1)

WEIZMANN INSTITUTE OF SCIENCE
Israel
Net EU contribution
€ 2 000 000,00
Address
Herzl Street 234
7610001 Rehovot

See on map

Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 000 000,00