Boosting metabolism in T cells: a tool to improve T cell therapy for chronic lymphocytic leukemia patients

Project Information

BOOTCAMP

Grant agreement ID: 864815

DOI

10.3030/864815

EC signature date 15 July 2020

Start date 1 August 2020

End date 31 January 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 997 662,00

EU contribution

€ 1 997 662,00

Coordinated by

STICHTING AMSTERDAM UMC
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (4)

Depletion of CLL cells by venetoclax treatment reverses oxidative stress and impaired glycolysis in CD4 T cells

Author(s): J A C van Bruggen 1 2 3, G J W van der Windt 1 2 3, M Hoogendoorn 4, J Dubois 1 2 3, Arnon P Kater 1 2 3, F S Peters 1 2 3
Published in: Blood Adv, 2022, Page(s) 4185-4195, ISSN 2473-9529
Publisher: American Society of Hematology
DOI: 10.1182/bloodadvances.2022007034

Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T-cell efficacy

Author(s): Jaco A C van Bruggen 1 2 3, Anne W J Martens 1 2 3, Joseph A Fraietta 4 5 6 7, Tom Hofland 1 2 3, Sanne H Tonino 1 2, Eric Eldering 3, Mark-David Levin 8, Peter J Siska 9, Sanne Endstra 1 2 3, Jeffrey C Rathmell 10, Carl H June 4 6, David L Porter 4, J Joseph Melenhorst 4 6, Arnon P Kater 1 2, Gerritje J W van der Windt 1 2 3
Published in: Blood, 2019, Page(s) 44-58, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2018885863

Enhanced Costimulatory Signaling Improves CAR T-cell Effector Responses in CLL

Author(s): McKensie A Collins 1 2 3, In-Young Jung 2 4, Ziran Zhao 1 2 3, Kimberly Apodaca 2 3, Weimin Kong 2 4, Stefan Lundh 1 2, Joseph A Fraietta 1 2 3 4 5, Arnon P Kater 6, Clare Sun 7, Adrian Wiestner 7, J Joseph Melenhorst 1 2 3 5
Published in: Cancer Res Commun, Issue 2, 2022, Page(s) 1089-1103, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/2767-9764.crc-22-0200

Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectors

Author(s): "Anne W J Martens # 1 2, Inga Kavazović # 3, Mia Krapić 3, Su Min Pack 1 2, Ramon Arens 4, Aldo Jongejan 5, Perry D Moerland 5, Eric Eldering 2, Gerritje J W van der Windt 1 2, Felix M Wensveen 3, Fleur S Peters # 1 2, Arnon P Kater"
Published in: Leukemia, 2023, Page(s) 606-616, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-023-01817-z