Targeting the Plant Cysteine Oxidases to Regulate Plant Stress Tolerance

Información del proyecto

PCOMOD

Identificador del acuerdo de subvención: 864888

DOI

10.3030/864888

Fecha de la firma de la CE 5 Febrero 2020

Fecha de inicio 1 Abril 2020

Fecha de finalización 31 Diciembre 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 995 253,00

Aportación de la UE

€ 1 995 253,00

Coordinado por

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (14)

Structures of Arabidopsis thaliana oxygen-sensing plant cysteine oxidases 4 and 5 enable targeted manipulation of their activity

Autores: Mark D. White, Laura Dalle Carbonare, Mikel Lavilla Puerta, Sergio Iacopino, Martin Edwards, Kate Dunne, Elisabete Pires, Colin Levy, Michael A. McDonough, Francesco Licausi, Emily Flashman
Publicado en: Proceedings of the National Academy of Sciences, Edición 117/37, 2020, Página(s) 23140-23147, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2000206117

Emerging roles for thiol dioxygenases as oxygen sensors

Autores: Dona M. Gunawardana, Karen C. Heathcote, Emily Flashman
Publicado en: The FEBS Journal, 2021, ISSN 1742-464X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/febs.16147

Targeting Plant Cysteine Oxidase Activity for Improved Submergence Tolerance

Autores: Leah J Taylor-Kearney; Emily Flashman
Publicado en: The Plant Journal, Edición 1365313X, 2021, ISSN 1365-313X
Editor: Wiley
DOI: 10.1111/tpj.15605

Plant Cysteine Oxidase Oxygen-Sensing Function Is Conserved in Early Land Plants and Algae

Autores: Leah J. Taylor-Kearney; Samuel Madden; Jack Wilson; William K. Myers; Dona M. Gunawardana; Elisabete Pires; Philip Holdship; Anthony Tumber; Rosalind E. M. Rickaby; Emily Flashman
Publicado en: ACS Bio & Med Chem Au, Edición 26942437, 2022, ISSN 2694-2437
Editor: American Chemical Society
DOI: 10.1021/acsbiomedchemau.2c00032

Oxygen sensing and plant adaptation to flooding in a changing climate

Autores: Tilo Renziehausen, Anna Dirr, Romy Schmidt-Schippers, Emily Flashman, Jos Schippers
Publicado en: Philosophical Transactions of the Royal Society B: Biological Sciences, Edición 380, 2025, ISSN 0962-8436
Editor: Royal Society of London
DOI: 10.1098/rstb.2024.0238

Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity

Autores: Emma U. Hammarlund, Emily Flashman, Sofie Mohlin, Francesco Licausi
Publicado en: Science, Edición 370/6515, 2020, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aba3512

Identification of novel plant cysteine oxidase inhibitors from a yeast chemical genetic screen

Autores: Mikel Lavilla-Puerta, Rebecca Latter, Francesca Bellè, Tiziana Cervelli, Alvaro Galli, Pierdomenico Perata, Andrea Chini, Emily Flashman, Beatrice Giuntoli
Publicado en: Journal of Biological Chemistry, Edición 299, 2024, Página(s) 105366, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2023.105366

Hypoxia‐activated fluorescent probes as markers of oxygen levels in plant cells and tissues

Autores: Monica Perri, M. Shahneawz Khan, Antoine L. D. Wallabregue, Viktoriia Voloboeva, Amber M. Ridgway, Edward N. Smith, Hannah Bolland, Ester M. Hammond, Stuart J. Conway, Daan A. Weits, Emily Flashman
Publicado en: New Phytologist, Edición 247, 2025, Página(s) 2998-3009, ISSN 0028-646X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/nph.70202

Evidence of an activity-enhancing conformational shift in Arabidopsis thaliana plant cysteine oxidase 4 induced by binding of substrate or substrate-mimics

Autores: Rebecca Latter, Jordi C.J. Hintzen, Laila M.N. Shah, Dona M. Gunawardana, Roberta M. Sher, Mark D. White, Jasmin Mecinović, Justin L.P. Benesch, Emily Flashman
Publicado en: Journal of Biological Chemistry, Edición 301, 2026, Página(s) 110770, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2025.110770

Contrasted NCED gene expression across conifers with rising and peaking abscisic acid responses to drought

Autores: Gabriele Rizzuto, Dapeng Wang, Jinhui Chen, Tin Hang Hung, Anne Charlott Fitzky, Emily Flashman, John J. MacKay
Publicado en: Plant Stress, Edición 14, 2025, Página(s) 100574, ISSN 2667-064X
Editor: Elsevier
DOI: 10.1016/j.stress.2024.100574

Measuring ROS and redox markers in plant cells

Autores: Salma Akter, Mohammad Shahneawz Khan, Edward N. Smith, Emily Flashman
Publicado en: RSC Chemical Biology, Edición 2/5, 2021, Página(s) 1384-1401, ISSN 2633-0679
Editor: Royal Society of Chemistry
DOI: 10.1039/d1cb00071c

N-terminal cysteine acetylation and oxidation patterns may define protein stability

Autores: Karen C. Heathcote, Thomas P. Keeley, Matti Myllykoski, Malin Lundekvam, Nina McTiernan, Salma Akter, Norma Masson, Peter J. Ratcliffe, Thomas Arnesen, Emily Flashman
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-49489-2

Measuring plant cysteine oxidase interactions with substrates using intrinsic tryptophan fluorescence

Autores: Dona M. Gunawardana, Daisy A. Southern, Emily Flashman
Publicado en: Scientific Reports, Edición 14, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-024-83508-y

Destined for destruction: The role of methionine aminopeptidases and plant cysteine oxidases in N-degron formation

Autores: Andrea Fuentes-Terrón, Rebecca Latter, Samuel Madden, Isabel Manrique-Gil, Jessenia Estrada, Noelia Arteaga, Inmaculada Sánchez-Vicente, Oscar Lorenzo, Emily Flashman
Publicado en: Plant Physiology, Edición 197, 2025, ISSN 0032-0889
Editor: American Society of Plant Biologists
DOI: 10.1093/plphys/kiae667

Book chapters (1)

Kinetic Measurements to Investigate the Oxygen-Sensing Properties of Plant Cysteine Oxidases

Autores: Anna Dirr, Dona M. Gunawardana, Emily Flashman
Publicado en: Methods in Molecular Biology, Oxygen Sensing, 2023, Página(s) 207-230
Editor: Springer US
DOI: 10.1007/978-1-0716-3080-8_13