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Mapping the impact of gut microbiota on brain and behaviour through the lens of GABA

Project description

Role of neurotransmitters from gut microbiota in brain function

Humans are over 99 % genetically identical. One alternative source of individual differences is the resident bacteria in the gastrointestinal tract, which are 40–90 % distinct between different individuals. Gut bacteria produce gamma-aminobutyric acid (GABA) and serotonin, molecules that function as neurotransmitters in the human brain. However, whether their production in the gut impacts behaviour and brain function in any way remains a mystery. The EU-funded GutBrainGABA project addresses this lack of knowledge focusing on the biochemistry of GABA-producing gut microbiota and their function. The project will answer a fundamental question about GABA production by gut bacteria, its modulation by probiotics and any impact it might have on GABA levels in the brain. This proposal involves approaches from psychology, neuroscience and gut microbiology to shed light on individual differences in human behaviour and brain function.

Call for proposal

ERC-2019-COG
See other projects for this call

Funding Scheme

ERC-COG - Consolidator Grant

Host institution

THE UNIVERSITY OF READING
Address
Whiteknights Campus Whiteknights House
RG6 6AH Reading
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 997 953

Beneficiaries (1)

THE UNIVERSITY OF READING
United Kingdom
EU contribution
€ 1 997 953
Address
Whiteknights Campus Whiteknights House
RG6 6AH Reading
Activity type
Higher or Secondary Education Establishments