Mechanisms of Microglia Synapse Communication

Project Information

MicroSynCom

Grant agreement ID: 865618

DOI

10.3030/865618

EC signature date 25 February 2020

Start date 1 September 2020

End date 31 August 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 687 476,00

EU contribution

€ 1 687 476,00

Coordinated by

DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Aberrant hippocampal Ca2+ micro-waves following synapsin-dependent adenoviral expression of Ca2+ indicators

Author(s): Nicola Masala, Manuel Mittag, Eleonora Ambrad Giovannetti, Darik A. O’Neil, Fabian Distler, Peter Rupprecht, Fritjof Helmchen, Rafael Yuste, Martin Fuhrmann, Heinz Beck, Michael Wenzel, Tony Kelly
Published in: eLife, 2024, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.93804.1

Next generation genetically encoded fluorescent sensors for serotonin

Author(s): Martin Kubitschke, Monika Müller, Lutz Wallhorn, Mauro Pulin, Manuel Mittag, Stefan Pollok, Tim Ziebarth, Svenja Bremshey, Jill Gerdey, Kristin Carolin Claussen, Kim Renken, Juliana Groß, Pascal Gneiße, Niklas Meyer, J. Simon Wiegert, Andreas Reiner, Martin Fuhrmann & Olivia Andrea Masseck
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-35200-w

O-LM interneurons: Gatekeepers of pyramidal neuron activity in the hippocampus

Author(s): Stefanie Poll, Martin Fuhrmann
Published in: Neuron, 2022, ISSN 1097-4199
Publisher: Elsevier
DOI: 10.1016/j.neuron.2022.04.022

Memory trace interference impairs recall in a mouse model of Alzheimer's disease.

Author(s): Stefanie Poll, Manuel Mittag; Musacchio, F.* ; Justus, L. C.* ; Giovannetti, E. A.* ; Steffen, J.* ; Wagner, J.* ; Zohren, L. ; Schoch, S. ; Schmidt, B. ; Jackson, W. S.* ; Ehninger, D.* ; Martin Fuhrmann (Last author)
Published in: Nature Neuroscience, 2020, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-020-0652-4

Microglial motility is modulated by neuronal activity and correlates with dendritic spine plasticity in the hippocampus of awake mice

Author(s): Felix Nebeling; Stefanie Poll; Lena C Justus;Julia Steffen; Kevin Keppler; Manuel Mittag; Martin Fuhrmann (Last author)
Published in: eLIFE, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.83176

Super-Resolution Microscopy Opens New Doors to Life at the Nanoscale

Author(s): Martin Fuhrmann, Nala Gockel, Misa Arizono, Yulia Dembitskaya, U Valentin Nägerl, Francesca Pennacchietti, Martina Damenti, Ilaria Testa, Katrin I Willig
Published in: Journal of Neuroscience, 2022, ISSN 1529-2401
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.1125-22.2022

Hippocampal hyperactivity in a rat model of Alzheimer’s disease

Author(s): Liudmila Sosulina, Manuel Mittag, Hans-Rüdiger Geis, Kerstin Hoffmann, Igor Klyubin, Yingjie Qi, Julia Steffen, Detlef Friedrichs, Niklas Henneberg, Falko Fuhrmann, Daniel Justus, Kevin Keppler, A. Claudio Cuello, Michael J. Rowan, Martin Fuhrmann, Stefan Remy
Published in: Journal of Neurochemistry, 2021, ISSN 1471-4159
Publisher: International Society of Neurochemistry
DOI: 10.1111/jnc.15323

Dual truncation of tau by caspase-2 accelerates its CHIP-mediated degradation

Author(s): Lydia Reinhardt, Fabrizio Musacchio, Maria Bichmann, Annika Behrendt, Ebru Ercan-Herbst, Juliane Stein, Isabelle Becher, Per Haberkant, Julia Mader, David C. Schöndorf, Melanie Schmitt, Jürgen Korffmann, Peter Reinhardt, Christian Pohl, Mikhail Savitski, Corinna Klein, Laura Gasparini, Martin Fuhrmann, Dagmar E. Ehrnhoefer
Published in: Neurobiology of Disease, Issue 182, 2023, Page(s) 106126, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2023.106126

Tracking changes in functionality and morphology of repopulated microglia in young and old mice

Author(s): Zuzanna M. Luczak-Sobotkowska, Patrycja Rosa, Maria Banqueri Lopez, Natalia Ochocka, Anna Kiryk, Anna M. Lenkiewicz, Martin Furhmann, Aleksander Jankowski, Bozena Kaminska
Published in: Journal of Neuroinflammation, 2024, ISSN 1742-2094
Publisher: BioMed Central
DOI: 10.1101/2024.07.12.603244

Elevated expression of complement C4 in the mouse prefrontal cortex causes schizophrenia-associated phenotypes

Author(s): Mélanie Druart, Marika Nosten-Bertrand, Stefanie Poll, Sophie Crux, Felix Nebeling, Célia Delhaye, Yaëlle Dubois, Manuel Mittag, Marion Leboyer, Ryad Tamouza, Martin Fuhrmann, Corentin Le Magueresse
Published in: Molecular Psychiatry, 2021, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-021-01081-6

Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability

Author(s): Fabio Bertan, Lena Wischhof, Liudmila Sosulina, Manuel Mittag, Dennis Dalügge, Alessandra Fornarelli, Fabrizio Gardoni, Elena Marcello, Monica Di Luca, Martin Fuhrmann, Stefan Remy, Daniele Bano, Pierluigi Nicotera
Published in: Cell Death and Differentiation, 2020, ISSN 1476-5403
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-020-0584-2

Minocycline treatment improves cognitive and functional plasticity in a preclinical mouse model of major depressive disorder

Author(s): Poggini, S. ; Lopez, M. B. ; Albanese, N. C. ; Golia, M. T. ; Ibáñez, F. G. ; Limatola, C. ; Martin Fuhrmann ; Lalowski, M. ; Tremblay, M.-E. ; Maggi, L. ; Kaminska, B. ; Branchi, I.
Published in: Behavioral Brain Research, 2023, ISSN 0166-4328
Publisher: Elsevier BV
DOI: 10.1016/j.bbr.2023.114295

Other (8)

Deficiency of actin depolymerizing factors ADF/Cfl1 in microglia decreases motility and impairs memory

Author(s): Sophie Crux, Marie Denise Roggan, Stefanie Poll, Felix C. Nebeling, Juliane Schiweck, Manuel Mittag, Fabrizio Musacchio, Julia Steffen, Katharina M. Wolff, Andrea Baral, Walter Witke, Christine Gurniak, Frank Bradke, Martin Fuhrmann
Published in: bioRxiv, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.27.615114

Microglia motility depends on neuronal activity and promotes structural plasticity in the hippocampus

Author(s): Felix C. Nebeling, Stefanie Poll, Lena C. Schmid, Manuel Mittag, Julia Steffen, Kevin Keppler, Martin Fuhrmann
Published in: bioRxiv, 2020
Publisher: CSHL
DOI: 10.1101/515759

PinkyCaMP a mScarlet-based calcium sensor with exceptional brightness, photostability, and multiplexing capabilities

Author(s): Ryan Fink, Shosei Imai, Nala Gockel, German Lauer, Kim Renken, Jonas Wietek, Paul J. Lamothe-Molina, Falko Fuhrmann, Manuel Mittag, Tim Ziebarth, Annika Canziani, Martin Kubitschke, Vivien Kistmacher, Anny Kretschmer, Eva Sebastian, Dietmar Schmitz, Takuya Terai, Jan Gründemann, Sami Hassan, Tommaso Patriarchi, Andreas Reiner, Martin Fuhrmann, Robert E. Campbell, Olivia Andrea Masseck
Published in: bioRxiv, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.12.16.628673

Dynamics of microglia-glioblastoma crosstalk at the far infiltration zone

Author(s): Felix C. Nebeling, Falko Fuhrmann, Manuel Mittag, Fabrizio Musacchio, Nala E. Gockel, Lea L. Friker, Sonia Leonardelli, Severin Filser, A Deli, Miriam Stork, Daniele Bano, Torsten Pietsch, Simona Parrinello, Michael Hoelzel, Ulrich Herrlinger, Paolo Salomoni, Martin Fuhrmann
Published in: bioRxiv, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.23.614016

Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution

Author(s): Falko Fuhrmann, Felix C. Nebeling, Fabrizio Musacchio, Manuel Mittag, Stefanie Poll, Monika Müller, Eleonora Ambrad Giovannetti, Michael Maibach, Barbara Schaffran, Emily Burnside, Ivy Chi Wai Chan, Alex Simon Lagurin, Nicole Reichenbach, Sanjeev Kaushalya, Hans Fried, Stefan Linden, Gabor C. Petzold, Gaia Tavosanis, Frank Bradke, Martin Fuhrmann
Published in: bioRxiv, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.08.28.610026

CX3CR1 modulates migration of resident microglia towards brain injury

Author(s): Jens Wagner, Cornelia Hoyer, Henrike Antony, Kristiina Lundgrén, Rabah Soliymani, Sophie Crux, Lena Justus, Kevin Keppler, Julia Steffen, Christian Kurts, Daniel R. Engel, Jochen Herms, Maciej Łałowski, Martin Fuhrmann
Published in: bioRxiv, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.23.614458

sDarken: Next generation genetically encoded fluorescent sensors for serotonin

Author(s): Martin Kubitschke, Monika Müller, Lutz Wallhorn,Mauro Pulin, Manuel Mittag, Stefan Pollok, Tim Ziebarth, Svenja Bremshey, Jill Gerdey, Kristin Carolin Claussen, Kim Renken, Juliana Groß, Niklas Meyer, Simon Wiegert, Andreas Reiner, Martin Fuhrmann, Olivia Andrea Masseck
Published in: bioRxiv, 2022
Publisher: bioRxiv
DOI: 10.1101/2022.03.10.483799

The Diagonal Band of Broca Regulates Olfactory-Mediated Behaviors by Modulating Odor-Evoked Responses Within the Olfactory Bulb

Author(s): Inna Schwarz, Monika Müller, Irina Pavlova, Jens Schweihoff, Fabrizio Musacchio, Manuel Mittag, Martin Fuhrmann, Martin K. Schwarz
Published in: bioRxiv, 2021
Publisher: bioRxiv
DOI: 10.2139/ssrn.3927424