Project description
Intracellular synthesis of nanomedicines
Exposed to smart man-engineered nanomedicines, living cells are able to transform and recycle them. Moreover, cells are capable of generating extracellular vesicles, which can play crucial roles in multiple physiological processes, both in health and disease. The goal of the EU-funded NanoBioMade project is to combine both biological events to deliver nanomedicines created by cells themselves using mesenchymal stem cells as the most relevant cell model. The first objective will be to demonstrate that the stem cells are capable of biosynthesising nanoparticles. The second objective will focus on nanoparticle biological encapsulation, taking advantage of the extracellular vesicles produced naturally by the stem cells. The last objective is to exploit biosynthesised nanoparticles and their bio-camouflage as anti-cancer photothermal agents.
Objective
Exposed to smart man-engineered nanomedicines, cells can profoundly transform and recycle them.
To communicate, or in response to exogenous stress, cells generate extracellular vesicles which can play crucial roles in multiple physiological processes, as for instance, and unfortunately, for cancer progression.
The goal of this proposal is to combine both biological events to deliver nanomedicines created by cells only, using mesenchymal stem cells as the most relevant cell model.
The focus of this proposal on nano-bio-production is three-fold.
- In the first instance, I aim to rationally develop novel strategies for bioinorganic intracellular synthesis of nanoparticles. The first aspect will be to demonstrate, as suggested by preliminary data, that nanoparticles degradation products can be de novo-synthesized nanoparticles! And also that nanoparticulate end products can also be obtained when cells are fed with soluble ionic salts. The vicarious synthesis using living cells as bioreactors, will allow creating functional, sophisticated and organism-friendly nanoparticles. Basic ingredients and little chemical proceedings should lead to advanced prospectively biological nano-tools. When iron and cobalt constituents will be used as precursors, cells will generate nanoparticles with magnetic and photothermal properties.
- The second focus is devoted to nanoparticles biological encapsulation. Indeed, in order to be useful, nanoparticles should be efficiently delivered to the target site. In the strategy to make 100% Bio Made nanomedicines, it is obvious there are no better delivery systems than the cells innate delivery systems, the extracellular vesicles, an especially the ones derived from stem cells, supposed to inherit from their natural tumour homing. Here, ground-breaking physically-inspired (hydrodynamic, light) approaches for production and loading of these vesicles with nanoparticles will be proposed and fully implemented. One specific aim wi
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology
- medical and health sciences medical biotechnology nanomedicine
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology
- engineering and technology nanotechnology nano-materials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-COG - Consolidator Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2019-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.