Insight into anti-glycan immunity
High-affinity secretory antibodies (sIgA) have the power to protect from infection and to manipulate gut microbiota composition. However, the design of vaccines that elicit sIgA secretion is limited by the inherently complex biochemistry of bacterial glycans and the need to deliver intact antigen via the highly degradative environment of the intestine. To address these problems, scientists of the EU-funded SNUGly project will generate a toolbox for glycan-binding antibody research to investigate various parameters such as the biophysical properties and the structure of glycan antigens. The project will contribute towards the optimal design of mucosal vaccines and the efficient release of high-affinity anti-glycan sIgA.
Call for proposal
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