Cellular control of membrane protein density in the endoplasmic reticulum via the unfolded protein response

Project Information

MemDense

Grant agreement ID: 866011

DOI

10.3030/866011

Project closed

EC signature date 19 December 2019

Start date 1 April 2020

End date 31 March 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 934 065,00

EU contribution

€ 1 934 065,00

Coordinated by

UNIVERSITAT DES SAARLANDES
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan (DMP)

Data Management Plan DMP

Publications

Peer reviewed articles (8)

A Quantitative Analysis of Cellular Lipid Compositions During Acute Proteotoxic ER Stress Reveals Specificity in the Production of Asymmetric Lipids

Author(s): John Reinhard, Carsten Mattes, Kristina Väth, Toni Radanović, Michal A. Surma, Christian Klose, Robert Ernst
Published in: Frontiers in Cell and Developmental Biology, Issue 8, 2020, Page(s) 756, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2020.00756

The Unfolded Protein Response as a Guardian of the Secretory Pathway

Author(s): Toni Radanović, Robert Ernst
Published in: Cells, Issue 10/11, 2021, Page(s) 2965, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10112965

MemPrep, a new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress

Author(s): John Reinhard, Leonhard Starke, Christian Klose, Per Haberkant, Henrik Hammarén, Frank Stein, Ofir Klein, Charlotte Berhorst, Heike Stumpf, James P Sáenz, Jochen Hub, Maya Schuldiner, Robert Ernst
Published in: The EMBO Journal, Issue 43, 2024, Page(s) 1653-1685, ISSN 1460-2075
Publisher: EMBOpress
DOI: 10.1038/s44318-024-00063-y

Endoplasmic Reticulum Membrane Homeostasis and the Unfolded Protein Response

Author(s): Robert Ernst, Mike F. Renne, Aamna Jain, Alexander von der Malsburg
Published in: Cold Spring Harbor Perspectives in Biology, Issue 16, 2024, Page(s) a041400, ISSN 1943-0264
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a041400

Membrane homeostasis beyond fluidity: control of membrane compressibility

Author(s): Mike F. Renne, Robert Ernst
Published in: Trends in Biochemical Sciences, Issue 48, 2024, Page(s) 963-977, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2023.08.004

Reversible tuning of membrane sterol levels by cyclodextrin in a dialysis setting

Author(s): Cynthia Alsayyah, Emmanuel Rodrigues, Julia Hach, Mike F. Renne, Robert Ernst
Published in: Biophysical Journal, Issue 124, 2025, Page(s) 1433-1445, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2025.03.020

Cysteine cross-linking in native membranes establishes the transmembrane architecture of Ire1

Author(s): Kristina Väth, Carsten Mattes, John Reinhard, Roberto Covino, Heike Stumpf, Gerhard Hummer, Robert Ernst
Published in: Journal of Cell Biology, Issue 220/8, 2021, Page(s) e202011078, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202011078

Systematic analysis of membrane contact sites in Saccharomyces cerevisiae uncovers modulators of cellular lipid distribution

Author(s): Inês Gomes Castro, Shawn P Shortill, Samantha Katarzyna Dziurdzik, Angela Cadou, Suriakarthiga Ganesan, Rosario Valenti, Yotam David, Michael Davey, Carsten Mattes, Ffion B Thomas, Reut Ester Avraham, Hadar Meyer, Amir Fadel, Emma J Fenech, Robert Ernst, Vanina Zaremberg, Tim P Levine, Christopher Stefan, Elizabeth Conibear, Maya Schuldiner
Published in: eLife, Issue 2050084X, 2022, Page(s) 74602, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.74602

Non-peer reviewed articles (2)

ERMES — from myths to molecules

Author(s): Mike F. Renne, Robert Ernst
Published in: Nature Reviews Molecular Cell Biology, Issue 25, 2024, Page(s) 161-161, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-023-00677-w

A lipid hydrolase and a ubiquitin ligase play hide‐and‐seek in the <scp>ER</scp> membrane

Author(s): Cynthia Alsayyah, Robert Ernst
Published in: The EMBO Journal, Issue 41, 2023, Page(s) e112384, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2022112384

Other (3)

A new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress

Author(s): John Reinhard, Leonhard Starke, Christian Klose, Per Haberkant, Henrik Hammarén, Frank Stein, Ofir Klein, Charlotte Berhorst, Heike Stumpf, James P. Sáenz, Jochen Hub, Maya Schuldiner, Robert Ernst
Published in: bioRxiv, 2022
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.09.15.508072

Reversible tuning of membrane sterol levels by cyclodextrin in a dialysis setting

Author(s): Cynthia Alsayyah, Emmanuel Rodrigues, Julia Hach, Mike F. Renne, Robert Ernst
Published in: bioRxiv, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.28.615506

Laboratory yeast strains are highly diverse in lipid metabolism

Author(s): Mike F. Renne, Richard Bachmann, Christian Klose, Thomas Hentrich, Julia M. Schulze-Hentrich, Robert Ernst
Published in: bioRxiv, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.02.13.638058