Cellular control of membrane protein density in the endoplasmic reticulum via the unfolded protein response

Project Information

MemDense

Grant agreement ID: 866011

DOI 10.3030/866011

EC signature date 19 December 2019

Start date 1 April 2020

End date 31 March 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 934 065,00

EU contribution € 1 934 065,00

Coordinated by

UNIVERSITAT DES SAARLANDES
Germany

Deliverables

Open Research Data Pilot (1)

Data Management Plan (DMP)

Data Management Plan DMP

Publications

Peer reviewed articles (5)

A Quantitative Analysis of Cellular Lipid Compositions During Acute Proteotoxic ER Stress Reveals Specificity in the Production of Asymmetric Lipids

Author(s): John Reinhard, Carsten Mattes, Kristina Väth, Toni Radanović, Michal A. Surma, Christian Klose, Robert Ernst
Published in: Frontiers in Cell and Developmental Biology, Issue 8, 2020, Page(s) 756, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2020.00756

Remodeling of yeast vacuole membrane lipidomes from the log (one phase) to stationary stage (two phases)

Author(s): John Reinhard, Chantelle L Leveille, Caitlin E Cornell, Alexey J Merz, Christian Klose, Robert Ernst, Sarah L Keller
Published in: Biophysical Journal, Issue 122/6, 2023, Page(s) 1043-1057, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2023.01.009

The Unfolded Protein Response as a Guardian of the Secretory Pathway

Author(s): Toni Radanović, Robert Ernst
Published in: Cells, Issue 10/11, 2021, Page(s) 2965, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10112965

Cysteine cross-linking in native membranes establishes the transmembrane architecture of Ire1

Author(s): Kristina Väth, Carsten Mattes, John Reinhard, Roberto Covino, Heike Stumpf, Gerhard Hummer, Robert Ernst
Published in: Journal of Cell Biology, Issue 220/8, 2021, Page(s) e202011078, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202011078

Systematic analysis of membrane contact sites in Saccharomyces cerevisiae uncovers modulators of cellular lipid distribution

Author(s): Inês Gomes Castro, Shawn P Shortill, Samantha Katarzyna Dziurdzik, Angela Cadou, Suriakarthiga Ganesan, Rosario Valenti, Yotam David, Michael Davey, Carsten Mattes, Ffion B Thomas, Reut Ester Avraham, Hadar Meyer, Amir Fadel, Emma J Fenech, Robert Ernst, Vanina Zaremberg, Tim P Levine, Christopher Stefan, Elizabeth Conibear, Maya Schuldiner
Published in: eLife, Issue 2050084X, 2022, Page(s) 74602, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.74602

Other (2)

A new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress

Author(s): John Reinhard, Leonhard Starke, Christian Klose, Per Haberkant, Henrik Hammarén, Frank Stein, Ofir Klein, Charlotte Berhorst, Heike Stumpf, James P. Sáenz, Jochen Hub, Maya Schuldiner, Robert Ernst
Published in: bioRxiv, 2022
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.09.15.508072

Remodeling of yeast vacuole membrane lipidomes from the log (1-phase) to stationary stage (2-phases)

Author(s): John Reinhard, Chantelle L. Leveille, Caitlin E. Cornell, Alexey J. Merz, Robert Ernst, Sarah L. Keller
Published in: bioRxiv, 2022
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.10.11.511736