Autoantibodies and chronic pain - Unraveling new mechanisms contributing to pain in rheumatic disease

Project Information

ANTIBODYPAIN

Grant agreement ID: 866075

DOI

10.3030/866075

Project closed

EC signature date 29 May 2020

Start date 1 October 2020

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 993 763,00

EU contribution

€ 1 993 763,00

Coordinated by

KAROLINSKA INSTITUTET
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Fibromyalgia patients have altered lipid concentrations associated with disease symptom severity and anti-satellite glial cell IgG antibodies

Author(s): Jenny E. Jakobsson, Joana Menezes, Emerson Krock, Matthew A. Hunt, Henrik Carlsson, Aina Vaivade, Payam Emami Khoonsari, Nilesh M. Agalave, Angelica Sandström, Diana Kadetoff, Jeanette Tour Sohlin, Ida Erngren, Asma Al-Grety, Eva Freyhult, Katalin Sandor, Eva Kosek, Camilla I. Svensson, Kim Kultima
Published in: The Journal of Pain, Issue 29, 2025, Page(s) 105331, ISSN 1526-5900
Publisher: Churchill Livingstone
DOI: 10.1016/j.jpain.2025.105331

Pain-like behavior in the collagen antibody-induced arthritis model is regulated by lysophosphatidic acid and activation of satellite glia cells

Author(s): Jie Su, Emerson Krock, Swapnali Barde, Ada Delaney, Johnny Ribeiro, Jungo Kato, Nilesh Agalave, Gustaf Wigerblad, Rosalia Matteo, Roger Sabbadini, Anna Josephson, Jerold Chun, Kim Kultima, Olivier Peyruchaud, Tomas Hökfelt, Camilla I. Svensson
Published in: Brain, Behavior, and Immunity, Issue 101, 2023, Page(s) 214-230, ISSN 0889-1591
Publisher: Academic Press
DOI: 10.1016/j.bbi.2022.01.003

Insights into FcγR involvement in pain-like behavior induced by an RA-derived anti-modified protein autoantibody

Author(s): Alexandra Jurczak, Katalin Sandor, Alex Bersellini Farinotti, Emerson Krock, Matthew A. Hunt, Nilesh M. Agalave, Julie Barbier, Nils Simon, Zhenggang Wang, Resti Rudjito, Juan Antonio Vazquez-Mora, Arisai Martinez-Martinez, Ramin Raoof, Niels Eijkelkamp, Caroline Grönwall, Lars Klareskog, Juan Miguel Jimenéz-Andrade, Fabien Marchand, Camilla I. Svensson
Published in: Brain, Behavior, and Immunity, Issue 113, 2023, Page(s) 212-227, ISSN 0889-1591
Publisher: Academic Press
DOI: 10.1016/j.bbi.2023.07.001

Characterisation of the antinociceptive effect of baricitinib in the collagen antibody-induced arthritis mouse model

Author(s): Nils Simon, Resti Rudjito, Lydia Moll, Katalin Sandor, Juan Antonio Vazquez-Mora, Zerina Kurtović, Alexandra Kuliszkiewicz, Carlos E. Morado Urbina, Sven David Arvidsson, Eduardo Mendoza-Sánchez, Giovanni E. López-Delgado, Qing Luo, Qiaolin Deng, Arisai Martínez Martínez, Jens Gammeltoft Gerwien, Paul Karila, Venkatesh Krishnan, Juan Miguel Jiménez-Andrade, Camilla I. Svensson
Published in: Annals of the Rheumatic Diseases, Issue 84, 2025, Page(s) 421-434, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1016/j.ard.2025.01.005

CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier

Author(s): Harald Lund, Matthew A. Hunt, Zerina Kurtović, Katalin Sandor, Paul B. Kägy, Noah Fereydouni, Anais Julien, Christian Göritz, Elisa Vazquez-Liebanas, Maarja Andaloussi Mäe, Alexandra Jurczak, Jinming Han, Keying Zhu, Robert A. Harris, Jon Lampa, Jonas Heilskov Graversen, Anders Etzerodt, Lisbet Haglund, Tony L. Yaksh, Camilla I. Svensson
Published in: Journal of Experimental Medicine, Issue 221, 2023, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20230675

Electrophoretic Delivery of Clinically Approved Anesthetic Drug for Chronic Pain Therapy

Author(s): Arghyamalya Roy, Alex Bersellini Farinotti, Theresia Arbring Sjöström, Tobias Abrahamsson, Dennis Cherian, Michal Karaday, Klas Tybrandt, David Nilsson, Magnus Berggren, David J. Poxson, Camilla I. Svensson, Daniel T. Simon
Published in: Advanced Therapeutics, Issue 6, 2023, ISSN 2366-3987
Publisher: Wiley
DOI: 10.1002/adtp.202300083

Combination of Two Monoclonal Anti–Citrullinated Protein Antibodies Induced Tenosynovitis, Pain, and Bone Loss in Mice in a Peptidyl Arginine Deiminase‐4–Dependent Manner

Author(s): Akilan Krishnamurthy, Alexandra Circiumaru, Jitong Sun, Yogan Kisten, Peter Damberg, Koji Sakuraba, Katalin Sandor, Patrik Jarvoll, Tunhe Zhou, Vivianne Malmström, Camilla I. Svensson, Aase Hensvold, Anca I. Catrina, Lars Klareskog, Bence Réthi
Published in: Arthritis & Rheumatology, Issue 75, 2023, Page(s) 164-170, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.42320

Anti-satellite glia cell IgG antibodies in fibromyalgia patients are related to symptom severity and to metabolite concentrations in thalamus and rostral anterior cingulate cortex

Author(s): Silvia Fanton, Joana Menezes, Emerson Krock, Angelica Sandström, Jeanette Tour, Katalin Sandor, Alexandra Jurczak, Matthew Hunt, Azar Baharpoor, Diana Kadetoff, Karin B. Jensen, Peter Fransson, Isabel Ellerbrock, Rouslan Sitnikov, Camilla I. Svensson, Eva Kosek
Published in: Brain, Behavior, and Immunity, Issue 114, 2024, Page(s) 371-382, ISSN 0889-1591
Publisher: Academic Press
DOI: 10.1016/j.bbi.2023.09.003

circRNA landscape in dorsal root ganglia from mice with collagen antibody-induced arthritis

Author(s): Zerina Kurtović, Katalin Sandor, Freija ter Heegde, Resti Rudjito, Camilla I. Svensson, Vinko Palada
Published in: Neurobiology of Pain, Issue 14, 2024, Page(s) 100142, ISSN 2452-073X
Publisher: Elsevier BV
DOI: 10.1016/j.ynpai.2023.100142

Sex-dependent effects of the targeted nerve growth factor mutation (R100E) on pain behavior, joint inflammation, and bone erosion in mice

Author(s): Carlos E. Morado-Urbina, Jungo Kato, Katalin Sandor, Juan Antonio Vazquez-Mora, Kristina Ängeby Möller, Nils Simon, Jaira Salcido, Arisai Martinez-Martinez, Enriqueta Munoz-Islas, Juan Miguel Jimenez-Andrade, Camilla I. Svensson
Published in: Pain, Issue 165, 2025, Page(s) 2814-2828, ISSN 0304-3959
Publisher: Elsevier BV
DOI: 10.1097/j.pain.0000000000003343

Passive transfer of fibromyalgia symptoms from patients to mice

Author(s): Goebel A, Krock E, Gentry C, Israel MR, Jurczak A, Urbina CM, Sandor K, Vastani N, Maurer M, Cuhadar U, Sensi S, Nomura Y, Menezes J, Baharpoor A, Brieskorn L, Sandström A, Tour J, Kadetoff D, Haglund L, Kosek E, Bevan S, Svensson CI, Andersson DA
Published in: The Journal of Clinical Investigation, 2021, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci144201

CCL25 in the cerebrospinal fluid is negatively correlated with fatigue in chronic pain patients

Author(s): Alexander H.C. Rosenström, Aisha Siddiqah Ahmed, Alex Bersellini Farinotti, Kim Kultima, Svante Berg, Martin F. Bjurström, Camilla I. Svensson, Eva Kosek
Published in: Brain, Behavior, and Immunity, Issue 128, 2025, Page(s) 54-64, ISSN 0889-1591
Publisher: Academic Press
DOI: 10.1016/j.bbi.2025.03.030

Fibromyalgia patients with elevated levels of anti–satellite glia cell immunoglobulin G antibodies present with more severe symptoms

Author(s): Emerson Krock, Carlos E. Morado-Urbina, Joana Menezes, Matthew A. Hunt, Angelica Sandström, Diana Kadetoff, Jeanette Tour, Vivek Verma, Kim Kultima, Lisbet Haglund, Carolina B. Meloto, Luda Diatchenko, Eva Kosek, Camilla I. Svensson
Published in: Pain, Issue 164, 2025, Page(s) 1828-1840, ISSN 0304-3959
Publisher: Elsevier BV
DOI: 10.1097/j.pain.0000000000002881

Other (1)

Vaccine-induced low-grade inflammation and sleep restriction induce coordinated motivational changes that facilitate recovery: An experimental two-hit stress model

Author(s): John Axelsson, Mats Lekander, Camilla I Svensson, Nils Simon, Alexandra Jurczak, Julie Lasselin, Leonie JT Balter
Published in: PsyArXiv Preprints, 2023
Publisher: Center for Open Science
DOI: 10.31234/osf.io/c67n9

Non-peer reviewed articles (1)

Bugs improve nerve regeneration: fasting-induced, microbiome-derived metabolite enhances peripheral nerve regeneration

Author(s): Zerina Kurtovic, Camilla I. Svensson, Emerson Krock
Published in: Signal Transduction and Targeted Therapy, Issue 7, 2022, ISSN 2059-3635
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41392-022-01186-6