Autoantibodies and chronic pain - Unraveling new mechanisms contributing to pain in rheumatic disease

Información del proyecto

ANTIBODYPAIN

Identificador del acuerdo de subvención: 866075

DOI

10.3030/866075

Proyecto cerrado

Fecha de la firma de la CE 29 Mayo 2020

Fecha de inicio 1 Octubre 2020

Fecha de finalización 30 Septiembre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 993 763,00

Aportación de la UE

€ 1 993 763,00

Coordinado por

KAROLINSKA INSTITUTET
Sweden

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (13)

Fibromyalgia patients have altered lipid concentrations associated with disease symptom severity and anti-satellite glial cell IgG antibodies

Autores: Jenny E. Jakobsson, Joana Menezes, Emerson Krock, Matthew A. Hunt, Henrik Carlsson, Aina Vaivade, Payam Emami Khoonsari, Nilesh M. Agalave, Angelica Sandström, Diana Kadetoff, Jeanette Tour Sohlin, Ida Erngren, Asma Al-Grety, Eva Freyhult, Katalin Sandor, Eva Kosek, Camilla I. Svensson, Kim Kultima
Publicado en: The Journal of Pain, Edición 29, 2025, Página(s) 105331, ISSN 1526-5900
Editor: Churchill Livingstone
DOI: 10.1016/j.jpain.2025.105331

Pain-like behavior in the collagen antibody-induced arthritis model is regulated by lysophosphatidic acid and activation of satellite glia cells

Autores: Jie Su, Emerson Krock, Swapnali Barde, Ada Delaney, Johnny Ribeiro, Jungo Kato, Nilesh Agalave, Gustaf Wigerblad, Rosalia Matteo, Roger Sabbadini, Anna Josephson, Jerold Chun, Kim Kultima, Olivier Peyruchaud, Tomas Hökfelt, Camilla I. Svensson
Publicado en: Brain, Behavior, and Immunity, Edición 101, 2023, Página(s) 214-230, ISSN 0889-1591
Editor: Academic Press
DOI: 10.1016/j.bbi.2022.01.003

Insights into FcγR involvement in pain-like behavior induced by an RA-derived anti-modified protein autoantibody

Autores: Alexandra Jurczak, Katalin Sandor, Alex Bersellini Farinotti, Emerson Krock, Matthew A. Hunt, Nilesh M. Agalave, Julie Barbier, Nils Simon, Zhenggang Wang, Resti Rudjito, Juan Antonio Vazquez-Mora, Arisai Martinez-Martinez, Ramin Raoof, Niels Eijkelkamp, Caroline Grönwall, Lars Klareskog, Juan Miguel Jimenéz-Andrade, Fabien Marchand, Camilla I. Svensson
Publicado en: Brain, Behavior, and Immunity, Edición 113, 2023, Página(s) 212-227, ISSN 0889-1591
Editor: Academic Press
DOI: 10.1016/j.bbi.2023.07.001

Characterisation of the antinociceptive effect of baricitinib in the collagen antibody-induced arthritis mouse model

Autores: Nils Simon, Resti Rudjito, Lydia Moll, Katalin Sandor, Juan Antonio Vazquez-Mora, Zerina Kurtović, Alexandra Kuliszkiewicz, Carlos E. Morado Urbina, Sven David Arvidsson, Eduardo Mendoza-Sánchez, Giovanni E. López-Delgado, Qing Luo, Qiaolin Deng, Arisai Martínez Martínez, Jens Gammeltoft Gerwien, Paul Karila, Venkatesh Krishnan, Juan Miguel Jiménez-Andrade, Camilla I. Svensson
Publicado en: Annals of the Rheumatic Diseases, Edición 84, 2025, Página(s) 421-434, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1016/j.ard.2025.01.005

CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier

Autores: Harald Lund, Matthew A. Hunt, Zerina Kurtović, Katalin Sandor, Paul B. Kägy, Noah Fereydouni, Anais Julien, Christian Göritz, Elisa Vazquez-Liebanas, Maarja Andaloussi Mäe, Alexandra Jurczak, Jinming Han, Keying Zhu, Robert A. Harris, Jon Lampa, Jonas Heilskov Graversen, Anders Etzerodt, Lisbet Haglund, Tony L. Yaksh, Camilla I. Svensson
Publicado en: Journal of Experimental Medicine, Edición 221, 2023, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20230675

Electrophoretic Delivery of Clinically Approved Anesthetic Drug for Chronic Pain Therapy

Autores: Arghyamalya Roy, Alex Bersellini Farinotti, Theresia Arbring Sjöström, Tobias Abrahamsson, Dennis Cherian, Michal Karaday, Klas Tybrandt, David Nilsson, Magnus Berggren, David J. Poxson, Camilla I. Svensson, Daniel T. Simon
Publicado en: Advanced Therapeutics, Edición 6, 2023, ISSN 2366-3987
Editor: Wiley
DOI: 10.1002/adtp.202300083

Combination of Two Monoclonal Anti–Citrullinated Protein Antibodies Induced Tenosynovitis, Pain, and Bone Loss in Mice in a Peptidyl Arginine Deiminase‐4–Dependent Manner

Autores: Akilan Krishnamurthy, Alexandra Circiumaru, Jitong Sun, Yogan Kisten, Peter Damberg, Koji Sakuraba, Katalin Sandor, Patrik Jarvoll, Tunhe Zhou, Vivianne Malmström, Camilla I. Svensson, Aase Hensvold, Anca I. Catrina, Lars Klareskog, Bence Réthi
Publicado en: Arthritis & Rheumatology, Edición 75, 2023, Página(s) 164-170, ISSN 2326-5191
Editor: Wiley
DOI: 10.1002/art.42320

Anti-satellite glia cell IgG antibodies in fibromyalgia patients are related to symptom severity and to metabolite concentrations in thalamus and rostral anterior cingulate cortex

Autores: Silvia Fanton, Joana Menezes, Emerson Krock, Angelica Sandström, Jeanette Tour, Katalin Sandor, Alexandra Jurczak, Matthew Hunt, Azar Baharpoor, Diana Kadetoff, Karin B. Jensen, Peter Fransson, Isabel Ellerbrock, Rouslan Sitnikov, Camilla I. Svensson, Eva Kosek
Publicado en: Brain, Behavior, and Immunity, Edición 114, 2024, Página(s) 371-382, ISSN 0889-1591
Editor: Academic Press
DOI: 10.1016/j.bbi.2023.09.003

circRNA landscape in dorsal root ganglia from mice with collagen antibody-induced arthritis

Autores: Zerina Kurtović, Katalin Sandor, Freija ter Heegde, Resti Rudjito, Camilla I. Svensson, Vinko Palada
Publicado en: Neurobiology of Pain, Edición 14, 2024, Página(s) 100142, ISSN 2452-073X
Editor: Elsevier BV
DOI: 10.1016/j.ynpai.2023.100142

Sex-dependent effects of the targeted nerve growth factor mutation (R100E) on pain behavior, joint inflammation, and bone erosion in mice

Autores: Carlos E. Morado-Urbina, Jungo Kato, Katalin Sandor, Juan Antonio Vazquez-Mora, Kristina Ängeby Möller, Nils Simon, Jaira Salcido, Arisai Martinez-Martinez, Enriqueta Munoz-Islas, Juan Miguel Jimenez-Andrade, Camilla I. Svensson
Publicado en: Pain, Edición 165, 2025, Página(s) 2814-2828, ISSN 0304-3959
Editor: Elsevier BV
DOI: 10.1097/j.pain.0000000000003343

Passive transfer of fibromyalgia symptoms from patients to mice

Autores: Goebel A, Krock E, Gentry C, Israel MR, Jurczak A, Urbina CM, Sandor K, Vastani N, Maurer M, Cuhadar U, Sensi S, Nomura Y, Menezes J, Baharpoor A, Brieskorn L, Sandström A, Tour J, Kadetoff D, Haglund L, Kosek E, Bevan S, Svensson CI, Andersson DA
Publicado en: The Journal of Clinical Investigation, 2021, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci144201

CCL25 in the cerebrospinal fluid is negatively correlated with fatigue in chronic pain patients

Autores: Alexander H.C. Rosenström, Aisha Siddiqah Ahmed, Alex Bersellini Farinotti, Kim Kultima, Svante Berg, Martin F. Bjurström, Camilla I. Svensson, Eva Kosek
Publicado en: Brain, Behavior, and Immunity, Edición 128, 2025, Página(s) 54-64, ISSN 0889-1591
Editor: Academic Press
DOI: 10.1016/j.bbi.2025.03.030

Fibromyalgia patients with elevated levels of anti–satellite glia cell immunoglobulin G antibodies present with more severe symptoms

Autores: Emerson Krock, Carlos E. Morado-Urbina, Joana Menezes, Matthew A. Hunt, Angelica Sandström, Diana Kadetoff, Jeanette Tour, Vivek Verma, Kim Kultima, Lisbet Haglund, Carolina B. Meloto, Luda Diatchenko, Eva Kosek, Camilla I. Svensson
Publicado en: Pain, Edición 164, 2025, Página(s) 1828-1840, ISSN 0304-3959
Editor: Elsevier BV
DOI: 10.1097/j.pain.0000000000002881

Other (1)

Vaccine-induced low-grade inflammation and sleep restriction induce coordinated motivational changes that facilitate recovery: An experimental two-hit stress model

Autores: John Axelsson, Mats Lekander, Camilla I Svensson, Nils Simon, Alexandra Jurczak, Julie Lasselin, Leonie JT Balter
Publicado en: PsyArXiv Preprints, 2023
Editor: Center for Open Science
DOI: 10.31234/osf.io/c67n9

Non-peer reviewed articles (1)

Bugs improve nerve regeneration: fasting-induced, microbiome-derived metabolite enhances peripheral nerve regeneration

Autores: Zerina Kurtovic, Camilla I. Svensson, Emerson Krock
Publicado en: Signal Transduction and Targeted Therapy, Edición 7, 2022, ISSN 2059-3635
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41392-022-01186-6