Advanced Cellular Hierarchical Tissue-Imitations based on Excluded Volume Effect

Project Information

ACHIEVE

Grant agreement ID: 866126

DOI

10.3030/866126

EC signature date 24 May 2020

Start date 1 September 2021

End date 31 August 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 076 770,00

EU contribution

€ 2 076 770,00

Coordinated by

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (30)

Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering

Author(s): Z Wu; Stefanie Korntner; Anne Maria Mullen; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Published in: Biomaterials and Biosystems, 2021, ISSN 2666-5344
Publisher: Elsevier
DOI: 10.1016/j.bbiosy.2021.100030

Modulation of stem cell response using biodegradable polyester films with different stiffness

Author(s): Sofia Ribeiro; Eugenia Pugliese; Stefanie Korntner; Emanuel M. Fernandes; Manuela E. Gomes; Rui L. Reis; Yves Bayon; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Published in: Biomedical Engineering Advances, 2021, ISSN 2667-0992
Publisher: Elsevier
DOI: 10.1016/j.bea.2021.100007

Development and characterisation of cytocompatible polyester substrates with tunable mechanical properties and degradation rate.

Author(s): Sofia Ribeiro; Ana M. Carvalho; Emanuel M. Fernandes; Manuela E. Gomes; Rui L. Reis; Yves Bayon; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Published in: Acta Biomaterialia, 2021, ISSN 1878-7568
Publisher: Elsevier
DOI: 10.1016/j.actbio.2020.11.026

Enthesis repair – State of play

Author(s): Eugenia Pugliese; Andrea Rossoni; Dimitrios I. Zeugolis
Published in: Biomaterials Advances, 2024, ISSN 2772-9508
Publisher: Elsevier
DOI: 10.1016/j.bioadv.2023.213740

Macromolecular crowding in animal component-free, xeno-free and foetal bovine serum media for human bone marrow mesenchymal stromal cell expansion and differentiation

Author(s): Korntner SH, Di Nubila A, Gaspar D, Zeugolis DI
Published in: Frontiers in Bioengineering and Biotechnology, 2023, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2023.1136827

Decellularized xenografts in regenerative medicine: From processing to clinical application

Author(s): Héctor Capella-Monsonís; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Published in: Xenotransplantation, 2021, ISSN 1399-3089
Publisher: Wiley
DOI: 10.1111/xen.12683

Assessing the combined effect of surface topography and substrate rigidity in human bone marrow stem cell cultures

Author(s): Ribeiro, S.; Pugliese, E.; Korntner, S. H.; Fernandes, Emanuel Mouta; Gomes, Manuela E.; Reis, R. L.; O’Riordan, A.; Bayon, Y.; Zeugolis, D. I.
Published in: Engineering in Life Sciences, 2022, ISSN 1618-2863
Publisher: Wiley
DOI: 10.1002/elsc.202200029

Hyaluronic Acid as Macromolecular Crowder in Equine Adipose-Derived Stem Cell Cultures.

Author(s): Sergio Garnica-Galvez; Sergio Garnica-Galvez; Sergio Garnica-Galvez; Stefanie Korntner; Ioannis Skoufos; Athina Tzora; N. Diakakis (Ν. Διακακησ); N. N. Prassinos; Dimitrios I. Zeugolis
Published in: Cells, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10040859

The synergistic effect of physicochemical in vitro microenvironment modulators in human bone marrow stem cell cultures

Author(s): Christina N.M. Ryan; Eugenia Pugliese; Naledi Shologu; Diana Gaspar; Peadar Rooney; Md Nahidul Islam; Alan O'Riordan; Manus J. Biggs; Matthew D. Griffin; Dimitrios I. Zeugolis
Published in: Biomaterials Advances, 2023, ISSN 2772-9508
Publisher: Elsevier
DOI: 10.1016/j.bioadv.2022.213196

A combined physicochemical approach towards human tenocyte phenotype maintenance.

Author(s): Christina N. M. Ryan; Eugenia Pugliese; Naledi Shologu; Diana Gaspar; Peadar Rooney; N. Islam; Alan O'Riordan; Manus J.P. Biggs; Matthew D. Griffin; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Published in: Materials Today Bio, 2021, ISSN 2590-0064
Publisher: Elsevier
DOI: 10.1016/j.mtbio.2021.100130

Macromolecular crowding in human tenocyte and skin fibroblast cultures: A comparative analysis

Author(s): Djalali-Cuevas A, Rettel M, Stein F, Savitski M, Kearns S, Kelly J, Biggs M, Skoufos I, Tzora A, Prassinos N, Diakakis N, Zeugolis DI.
Published in: Materials Today Bio, 2024, ISSN 2590-0064
Publisher: Elsevier
DOI: 10.1016/j.mtbio.2024.100977

Development of three-layer collagen scaffolds to spatially direct tissue-specific cell differentiation for enthesis repair

Author(s): Pugliese E, Sallent I, Ribeiro S, Trotier A, Korntner SH, Bayon Y, Zeugolis DI
Published in: Materials Today Bio, 2023, ISSN 2590-0064
Publisher: Elsevier
DOI: 10.1016/j.mtbio.2023.100584

It is time to crowd your cell culture media – Physicochemical considerations with biological consequences

Author(s): Tsiapalis D, Zeugolis DI
Published in: Biomaterials, 2021, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2021.120943

Bioinspired in vitro microenvironments to control cell fate: focus on macromolecular crowding

Author(s): Zeugolis DI
Published in: AMERICAN JOURNAL OF PHYSIOLOGY CELL PHYSIOLOGY, 2021, ISSN 1522-1563
Publisher: AMERICAN JOURNAL OF PHYSIOLOGY
DOI: 10.1152/ajpcell.00380.2020

Allogeneic serum and macromolecular crowding maintain native equine tenocyte function in culture

Author(s): Andrea Rampin; Ioannis Skoufos; Michael Raghunath; Athina Tzora; Nikolaos Diakakis; Nikitas Prassinos; Dimitrios I. Zeugolis
Published in: Cells, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11091562

Tissue origin matters: Maintenance of tenogenic phenotype on the tendon and not skin collagen‐derived devices

Author(s): Anna Sorushanova; Dimitrios Tsiapalis; Ioannis Skoufos; Athina Tzora; Una FitzGerald; Anne M. Mullen; Dimitrios I. Zeugolis
Published in: MedComm – Biomaterials and Applications, 2022, ISSN 2769-643X
Publisher: Wiley
DOI: 10.1002/mba2.24

Macromolecular crowding in equine bone marrow mesenchymal stromal cell cultures using single and double hyaluronic acid macromolecules

Author(s): Sergio Garnica-Galvez; Ioannis Skoufos; Athina Tzora; Nikolaos Diakakis; Nikitas Prassinos; Dimitrios I. Zeugolis
Published in: Acta Biomaterialia, 2023, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2023.08.042

In the quest of the optimal chondrichthyan for the development of collagen sponges for articular cartilage

Author(s): Z Wu; Stefanie Korntner; Anne Maria Mullen; Dimitrios I. Zeugolis
Published in: Journal of Science: Advanced Materials and Devices, 2021, ISSN 2468-2179
Publisher: Elsevier
DOI: 10.1016/j.jsamd.2021.04.002

Macromolecular crowding transforms regenerative medicine by enabling the accelerated development of functional and truly three-dimensional cell assembled micro tissues

Author(s): De Pieri A, Korntner SH, Capella-Monsonis H, Tsiapalis D, Kostjuk SV, Churbanov S, Timashev P, Gorelov A, Rochev Y, Zeugolis DI
Published in: Biomaterials, 2022, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2022.121674

Transforming eukaryotic cell culture with macromolecular crowding

Author(s): Raghunath M, Zeugolis DI
Published in: Trends in Biochemical Sciences, 2021, ISSN 1362-4326
Publisher: Cell Press
DOI: 10.1016/j.tibs.2021.04.006

It Takes Two to Tango: Controlling Human Mesenchymal Stromal Cell Response via Substrate Stiffness and Surface Topography

Author(s): Sofia Ribeiro; Alexandre Watigny; Yves Bayon; Manus Biggs; Dimitrios I. Zeugolis
Published in: Advanced NanoBiomed Research, Vol 4, Iss 1, Pp n/a-n/a (2024), Issue 1, 2024, ISSN 2699-9307
Publisher: Wiley-VCH GmbH
DOI: 10.1002/anbr.202300042

Adapting the Scar-in-a-Jar to Skin Fibrosis and Screening Traditional and Contemporary Anti-Fibrotic Therapies

Author(s): Coentro JQ, May U, Prince S, Zwaagstra J, Ritvos O, Järvinen TAH, Zeugolis DI
Published in: Frontiers in Bioengineering and Biotechnology, 2021, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2021.756399

Dual drug delivery collagen vehicles for modulation of skin fibrosis in vitro

Author(s): João Q Coentro; Alessia di Nubila; Ulrike May; Stuart Prince; John Zwaagstra; Tero A H Järvinen; Dimitrios I Zeugolis
Published in: Biomedical Materials, 2022, ISSN 1748-605X
Publisher: IOP
DOI: 10.1088/1748-605x/ac5673

Extracellular matrix-based biomaterials as adipose-derived stem cell delivery vehicles in wound healing: a comparative study between a collagen scaffold and two xenografts

Author(s): Héctor Capella-Monsonís; Andrea De Pieri; Rita Peixoto; Stefanie Korntner; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Published in: Stem Cell Research & Therapy, 2020, ISSN 1757-6512
Publisher: BioMed Central
DOI: 10.1186/s13287-020-02021-x

Macromolecular crowding in the development of a three-dimensional organotypic human breast cancer model.

Author(s): Naledi Shologu; Mehmet Gurdal; Eva Szegezdi; Una FitzGerald; Dimitrios I. Zeugolis
Published in: Biomaterials, 2022, ISSN 1878-5905
Publisher: Elsevier
DOI: 10.1016/j.biomaterials.2022.121642

Carrageenan as a macromolecular crowding agent in human umbilical cord derived mesenchymal stromal cell culture

Author(s): Shanshan, Du; Stephen J, Elliman; Dimitrios I, Zeugolis; Timothy, O'Brien
Published in: International Journal of Biological Macromolecules, Issue 1, 2023, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2023.126353

Physicochemical cues are not potent regulators of human dermal fibroblast trans-differentiation

Author(s): Ryan CNM, Pugliese E, Shologu N, Gaspar D, Rooney P, Islam MN, O'Riordan A, Biggs MJ, Griffin MD, Zeugolis DI.
Published in: Biomaterials and Biosystems, 2023, ISSN 2666-5344
Publisher: Elsevier
DOI: 10.1016/j.bbiosy.2023.100079

Editorial: Highlights From TERMIS EU 2019.

Author(s): Maria Chatzinikolaidou; Maria Chatzinikolaidou; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Published in: Frontiers in Bioengineering and Biotechnology, Vol 8 (2020), Issue 2, 2020, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2020.604661

The Influence of Bloom Index, Endotoxin Levels and Polyethylene Glycol Succinimidyl Glutarate Crosslinking on the Physicochemical and Biological Properties of Gelatin Biomaterials.

Author(s): Z Wu; Stefanie Korntner; Jos Olijve; Anne Maria Mullen; Dimitios I. Zeugolis
Published in: Biomolecules, 2021, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom11071003

Electric field stimulation for tissue engineering applications.

Author(s): Christina N. M. Ryan; Meletios N. Doulgkeroglou; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Published in: BMC Biomedical Engineering, 2021, ISSN 2524-4426
Publisher: BMC
DOI: 10.1186/s42490-020-00046-0