Advanced Cellular Hierarchical Tissue-Imitations based on Excluded Volume Effect

Informations projet

ACHIEVE

N° de convention de subvention: 866126

DOI

10.3030/866126

Date de signature de la CE 24 Mai 2020

Date de début 1 Septembre 2021

Date de fin 31 Août 2026

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total

€ 2 076 770,00

Contribution de l’UE

€ 2 076 770,00

Coordonné par

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland

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Publications

Peer reviewed articles (30)

Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering

Auteurs: Z Wu; Stefanie Korntner; Anne Maria Mullen; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Publié dans: Biomaterials and Biosystems, 2021, ISSN 2666-5344
Éditeur: Elsevier
DOI: 10.1016/j.bbiosy.2021.100030

Modulation of stem cell response using biodegradable polyester films with different stiffness

Auteurs: Sofia Ribeiro; Eugenia Pugliese; Stefanie Korntner; Emanuel M. Fernandes; Manuela E. Gomes; Rui L. Reis; Yves Bayon; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Publié dans: Biomedical Engineering Advances, 2021, ISSN 2667-0992
Éditeur: Elsevier
DOI: 10.1016/j.bea.2021.100007

Development and characterisation of cytocompatible polyester substrates with tunable mechanical properties and degradation rate.

Auteurs: Sofia Ribeiro; Ana M. Carvalho; Emanuel M. Fernandes; Manuela E. Gomes; Rui L. Reis; Yves Bayon; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Publié dans: Acta Biomaterialia, 2021, ISSN 1878-7568
Éditeur: Elsevier
DOI: 10.1016/j.actbio.2020.11.026

Enthesis repair – State of play

Auteurs: Eugenia Pugliese; Andrea Rossoni; Dimitrios I. Zeugolis
Publié dans: Biomaterials Advances, 2024, ISSN 2772-9508
Éditeur: Elsevier
DOI: 10.1016/j.bioadv.2023.213740

Macromolecular crowding in animal component-free, xeno-free and foetal bovine serum media for human bone marrow mesenchymal stromal cell expansion and differentiation

Auteurs: Korntner SH, Di Nubila A, Gaspar D, Zeugolis DI
Publié dans: Frontiers in Bioengineering and Biotechnology, 2023, ISSN 2296-4185
Éditeur: Frontiers
DOI: 10.3389/fbioe.2023.1136827

Decellularized xenografts in regenerative medicine: From processing to clinical application

Auteurs: Héctor Capella-Monsonís; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Publié dans: Xenotransplantation, 2021, ISSN 1399-3089
Éditeur: Wiley
DOI: 10.1111/xen.12683

Assessing the combined effect of surface topography and substrate rigidity in human bone marrow stem cell cultures

Auteurs: Ribeiro, S.; Pugliese, E.; Korntner, S. H.; Fernandes, Emanuel Mouta; Gomes, Manuela E.; Reis, R. L.; O’Riordan, A.; Bayon, Y.; Zeugolis, D. I.
Publié dans: Engineering in Life Sciences, 2022, ISSN 1618-2863
Éditeur: Wiley
DOI: 10.1002/elsc.202200029

Hyaluronic Acid as Macromolecular Crowder in Equine Adipose-Derived Stem Cell Cultures.

Auteurs: Sergio Garnica-Galvez; Sergio Garnica-Galvez; Sergio Garnica-Galvez; Stefanie Korntner; Ioannis Skoufos; Athina Tzora; N. Diakakis (Ν. Διακακησ); N. N. Prassinos; Dimitrios I. Zeugolis
Publié dans: Cells, 2021, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells10040859

The synergistic effect of physicochemical in vitro microenvironment modulators in human bone marrow stem cell cultures

Auteurs: Christina N.M. Ryan; Eugenia Pugliese; Naledi Shologu; Diana Gaspar; Peadar Rooney; Md Nahidul Islam; Alan O'Riordan; Manus J. Biggs; Matthew D. Griffin; Dimitrios I. Zeugolis
Publié dans: Biomaterials Advances, 2023, ISSN 2772-9508
Éditeur: Elsevier
DOI: 10.1016/j.bioadv.2022.213196

A combined physicochemical approach towards human tenocyte phenotype maintenance.

Auteurs: Christina N. M. Ryan; Eugenia Pugliese; Naledi Shologu; Diana Gaspar; Peadar Rooney; N. Islam; Alan O'Riordan; Manus J.P. Biggs; Matthew D. Griffin; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Publié dans: Materials Today Bio, 2021, ISSN 2590-0064
Éditeur: Elsevier
DOI: 10.1016/j.mtbio.2021.100130

Macromolecular crowding in human tenocyte and skin fibroblast cultures: A comparative analysis

Auteurs: Djalali-Cuevas A, Rettel M, Stein F, Savitski M, Kearns S, Kelly J, Biggs M, Skoufos I, Tzora A, Prassinos N, Diakakis N, Zeugolis DI.
Publié dans: Materials Today Bio, 2024, ISSN 2590-0064
Éditeur: Elsevier
DOI: 10.1016/j.mtbio.2024.100977

Development of three-layer collagen scaffolds to spatially direct tissue-specific cell differentiation for enthesis repair

Auteurs: Pugliese E, Sallent I, Ribeiro S, Trotier A, Korntner SH, Bayon Y, Zeugolis DI
Publié dans: Materials Today Bio, 2023, ISSN 2590-0064
Éditeur: Elsevier
DOI: 10.1016/j.mtbio.2023.100584

It is time to crowd your cell culture media – Physicochemical considerations with biological consequences

Auteurs: Tsiapalis D, Zeugolis DI
Publié dans: Biomaterials, 2021, ISSN 0142-9612
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2021.120943

Bioinspired in vitro microenvironments to control cell fate: focus on macromolecular crowding

Auteurs: Zeugolis DI
Publié dans: AMERICAN JOURNAL OF PHYSIOLOGY CELL PHYSIOLOGY, 2021, ISSN 1522-1563
Éditeur: AMERICAN JOURNAL OF PHYSIOLOGY
DOI: 10.1152/ajpcell.00380.2020

Allogeneic serum and macromolecular crowding maintain native equine tenocyte function in culture

Auteurs: Andrea Rampin; Ioannis Skoufos; Michael Raghunath; Athina Tzora; Nikolaos Diakakis; Nikitas Prassinos; Dimitrios I. Zeugolis
Publié dans: Cells, 2022, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells11091562

Tissue origin matters: Maintenance of tenogenic phenotype on the tendon and not skin collagen‐derived devices

Auteurs: Anna Sorushanova; Dimitrios Tsiapalis; Ioannis Skoufos; Athina Tzora; Una FitzGerald; Anne M. Mullen; Dimitrios I. Zeugolis
Publié dans: MedComm – Biomaterials and Applications, 2022, ISSN 2769-643X
Éditeur: Wiley
DOI: 10.1002/mba2.24

Macromolecular crowding in equine bone marrow mesenchymal stromal cell cultures using single and double hyaluronic acid macromolecules

Auteurs: Sergio Garnica-Galvez; Ioannis Skoufos; Athina Tzora; Nikolaos Diakakis; Nikitas Prassinos; Dimitrios I. Zeugolis
Publié dans: Acta Biomaterialia, 2023, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1016/j.actbio.2023.08.042

In the quest of the optimal chondrichthyan for the development of collagen sponges for articular cartilage

Auteurs: Z Wu; Stefanie Korntner; Anne Maria Mullen; Dimitrios I. Zeugolis
Publié dans: Journal of Science: Advanced Materials and Devices, 2021, ISSN 2468-2179
Éditeur: Elsevier
DOI: 10.1016/j.jsamd.2021.04.002

Macromolecular crowding transforms regenerative medicine by enabling the accelerated development of functional and truly three-dimensional cell assembled micro tissues

Auteurs: De Pieri A, Korntner SH, Capella-Monsonis H, Tsiapalis D, Kostjuk SV, Churbanov S, Timashev P, Gorelov A, Rochev Y, Zeugolis DI
Publié dans: Biomaterials, 2022, ISSN 0142-9612
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2022.121674

Transforming eukaryotic cell culture with macromolecular crowding

Auteurs: Raghunath M, Zeugolis DI
Publié dans: Trends in Biochemical Sciences, 2021, ISSN 1362-4326
Éditeur: Cell Press
DOI: 10.1016/j.tibs.2021.04.006

It Takes Two to Tango: Controlling Human Mesenchymal Stromal Cell Response via Substrate Stiffness and Surface Topography

Auteurs: Sofia Ribeiro; Alexandre Watigny; Yves Bayon; Manus Biggs; Dimitrios I. Zeugolis
Publié dans: Advanced NanoBiomed Research, Vol 4, Iss 1, Pp n/a-n/a (2024), Numéro 1, 2024, ISSN 2699-9307
Éditeur: Wiley-VCH GmbH
DOI: 10.1002/anbr.202300042

Adapting the Scar-in-a-Jar to Skin Fibrosis and Screening Traditional and Contemporary Anti-Fibrotic Therapies

Auteurs: Coentro JQ, May U, Prince S, Zwaagstra J, Ritvos O, Järvinen TAH, Zeugolis DI
Publié dans: Frontiers in Bioengineering and Biotechnology, 2021, ISSN 2296-4185
Éditeur: Frontiers
DOI: 10.3389/fbioe.2021.756399

Dual drug delivery collagen vehicles for modulation of skin fibrosis in vitro

Auteurs: João Q Coentro; Alessia di Nubila; Ulrike May; Stuart Prince; John Zwaagstra; Tero A H Järvinen; Dimitrios I Zeugolis
Publié dans: Biomedical Materials, 2022, ISSN 1748-605X
Éditeur: IOP
DOI: 10.1088/1748-605x/ac5673

Extracellular matrix-based biomaterials as adipose-derived stem cell delivery vehicles in wound healing: a comparative study between a collagen scaffold and two xenografts

Auteurs: Héctor Capella-Monsonís; Andrea De Pieri; Rita Peixoto; Stefanie Korntner; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Publié dans: Stem Cell Research & Therapy, 2020, ISSN 1757-6512
Éditeur: BioMed Central
DOI: 10.1186/s13287-020-02021-x

Macromolecular crowding in the development of a three-dimensional organotypic human breast cancer model.

Auteurs: Naledi Shologu; Mehmet Gurdal; Eva Szegezdi; Una FitzGerald; Dimitrios I. Zeugolis
Publié dans: Biomaterials, 2022, ISSN 1878-5905
Éditeur: Elsevier
DOI: 10.1016/j.biomaterials.2022.121642

Carrageenan as a macromolecular crowding agent in human umbilical cord derived mesenchymal stromal cell culture

Auteurs: Shanshan, Du; Stephen J, Elliman; Dimitrios I, Zeugolis; Timothy, O'Brien
Publié dans: International Journal of Biological Macromolecules, Numéro 1, 2023, ISSN 0141-8130
Éditeur: Elsevier BV
DOI: 10.1016/j.ijbiomac.2023.126353

Physicochemical cues are not potent regulators of human dermal fibroblast trans-differentiation

Auteurs: Ryan CNM, Pugliese E, Shologu N, Gaspar D, Rooney P, Islam MN, O'Riordan A, Biggs MJ, Griffin MD, Zeugolis DI.
Publié dans: Biomaterials and Biosystems, 2023, ISSN 2666-5344
Éditeur: Elsevier
DOI: 10.1016/j.bbiosy.2023.100079

Editorial: Highlights From TERMIS EU 2019.

Auteurs: Maria Chatzinikolaidou; Maria Chatzinikolaidou; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Publié dans: Frontiers in Bioengineering and Biotechnology, Vol 8 (2020), Numéro 2, 2020, ISSN 2296-4185
Éditeur: Frontiers
DOI: 10.3389/fbioe.2020.604661

The Influence of Bloom Index, Endotoxin Levels and Polyethylene Glycol Succinimidyl Glutarate Crosslinking on the Physicochemical and Biological Properties of Gelatin Biomaterials.

Auteurs: Z Wu; Stefanie Korntner; Jos Olijve; Anne Maria Mullen; Dimitios I. Zeugolis
Publié dans: Biomolecules, 2021, ISSN 2218-273X
Éditeur: MDPI
DOI: 10.3390/biom11071003

Electric field stimulation for tissue engineering applications.

Auteurs: Christina N. M. Ryan; Meletios N. Doulgkeroglou; Dimitrios I. Zeugolis; Dimitrios I. Zeugolis
Publié dans: BMC Biomedical Engineering, 2021, ISSN 2524-4426
Éditeur: BMC
DOI: 10.1186/s42490-020-00046-0