Project description
Understanding ruminants’ microbes to protect the environment
Ruminants are animals requiring complex microbial communities to digest plant fibers. The EU-funded RuMinimum aims to understand how the ruminant and its microbes coexist and how the microbial community sustains the life of its host. The project will be based on a research platform which will involve germ-free ruminant animals, modeling, genomics, metabolomics, as well as animal and microbial physiology. Eventually, the project will provide knowledge on how to modulate the physiology of ruminants towards a better feed efficiency, leading to a lower methane production.
Objective
Ruminants represent a paradigmatic case of obligatory host-microbiome relationships. These animals require complex microbial communities to digest plant fibers. Which functions are essential and how the assembly of these functions impacts host physiology remain unknown. My goal is to understand the underlying aspects that allow the host and its microbes to coexist and to identify the essential requirements of this microbial community to sustain the life of the host. This proposal aims to address this ambitious and fundamental challenge. These efforts build on a unique research platform involving germ-free ruminant animals, modeling, genomics, metabolomics, as well as animal and microbial physiology, developed over nine years of experience working with animal microbiomes. To do so, I propose to identify the minimum rumen community (RuMinimum) using top-down and bottom-up approaches that will complement each other. Once defined, the RuMinimum will serve as a platform for experimenting and understanding how the ecosystem functions and supports the life of the host, and how to modulate it. We will specifically augment and decrease functional redundancy and richness at different edges of the trophic network and measure their impact on ecosystem function and host physiology. These endeavors will allow us to learn how to modulate host physiology towards better feed efficiency or lower methane production, which will have an immense environmental and agricultural impact. The results of this project will be relevant not only to ruminants but also to other gut ecosystems and anaerobic, carbon-degrading communities in general. Our research efforts will lead to new paradigms and concepts vis-a-vis microbial community assembly, the design of synthetic microbial communities, and host-microbiome interactions, with strong scientific and applicative potential.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering fibers
- natural sciences biological sciences genetics
- natural sciences biological sciences ecology ecosystems
- natural sciences chemical sciences organic chemistry aliphatic compounds
- natural sciences biological sciences microbiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-COG - Consolidator Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2019-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
84105 Beer Sheva
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.