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Deciphering the effects of locus coeruleus activity on whole-brain dynamics and neurovascular coupling

Project description

How blue spots in brainstem modulate whole-brain dynamics

The locus coeruleus (LC) is a set of blue spots found in the brainstem, where the base of the brain connects to the spinal cord. Its neural cells are blue because they make and release a specific chemical signal called noradrenaline – a stress signal released when we experience fear and stress. The EU-funded LC-FMRI project will assess whole-brain responses and functional network reconfiguration. Using ultra-high field functional magnetic resonance imaging (fMRI), it will perform an optogenetic LC stimulation in awake mice to avoid the effects of anaesthesia. The project will lay the foundation for studying how LC modulates whole-brain dynamics in health and disease using fMRI, with high potential for translation to biomedical applications.

Field of science

  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds
  • /medical and health sciences/clinical medicine/radiology/medical imaging/magnetic resonance imaging

Call for proposal

H2020-WF-01-2018
See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD
Address
Avenida Brasilia, Centro De Investigacao Da Fundacao Champalimaud
1400-038 Lisboa
Portugal
Activity type
Research Organisations
EU contribution
€ 147 815,04