Descripción del proyecto
Pauta posológica inteligente para el trastorno por déficit de atención con hiperactividad gracias a una tecnología innovadora
El trastorno por déficit de atención con hiperactividad (TDAH) es una afección neuroconductual de inicio en la infancia que combina la falta de atención con la hiperactividad, lo que afecta a múltiples aspectos de la vida. Los estimulantes son los principales fármacos eficaces para el tratamiento del TDAH, clasificados como sustancias controladas con potencial adictivo y efectos secundarios, por lo que requieren un ajuste posológico a lo largo de la vida del paciente. El objetivo del proyecto OnDosis01, financiado con fondos europeos, es desarrollar un dispositivo terapéutico que permita un tratamiento eficaz del TDAH. Esta tecnología introducirá una nueva forma de administrar el tratamiento al integrar el autocontrol de la medicación como una pauta posológica inteligente. La integración simplificará el ajuste posológico, lo que permitirá mejorar la adhesión al tratamiento y reducirá el riesgo de consumo excesivo mediante un cierre inviolable.
Objetivo
The goal of this project is to develop a therapy that allows for more effective management of attention-deficit hyperactivity disorder (ADHD). ADHD is a common, childhood onset, neurobehavioural disorder characterised by a combination of inattention, hyperactivity and impulsivity impairing multiple areas of life. Stimulants are the most widely used ADHD medications and are proven effective on ADHD symptoms, but classified as controlled substances they are associated with concerns about side effects and potential for abuse. In addition, they require careful dose titration at initiation and throughout the patients’ life.
OnDosis aims to address these challenges by developing a novel “combination product”, prescribed as an ADHD treatment regime, that combines a technological platform with stimulant active compounds. This integrated solution will simplify dose titration, enable ease of swallowing, offer adherence support and self-monitoring checks. Importantly, OnDosis’ solution is a personalised device with the potential to reduce risk for medication abuse through tamper resistance and tamper evident features.
The ultimate success of the project will depend on generation of clinical data which will support partnering and out-licensing. OnDosis plans to apply for SMEi Phase 2 grant to take the product through required clinical studies, and then go to market through a licensing agreement with a strong commercial partner. OnDosis has a strong network established with potential pharma partners and investors, and has already gained support from investors that offer strategic support to the company.
The burden of ADHD is increasing and the unmet need is growing. This encourages OnDosis in the endeavour of a needs-driven research to address this widespread challenge. Market research with several stakeholders in healthcare have convinced OnDosis of the potential to bring significant impact to patients with ADHD through this novel technology.
Ámbito científico
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-SMEInst-2018-2020-1
Régimen de financiación
SME-1 - SME instrument phase 1Coordinador
431 50 MOLNDAL
Suecia
Organización definida por ella misma como pequeña y mediana empresa (pyme) en el momento de la firma del acuerdo de subvención.