Livrables
The toolbox will be available via an online portal and include SOPs, guidelines for best practices, reference materials, quality parameters, analysis tools, criteria for establishing reference values, and will provide access to a repository of multi-omic data.
The guidelines will describe how to access HTA support service developed by EATRIS
Reference protocols/manual for individual omics methodsDescription of reference technological protocols for transcriptomic, proteomic and metabolomic analysis in biological samples
Translational toolkit for global researchersThe toolkit will be a key resource made available on the website of EATRIS international collaboration intiative Translation Together It will include international recommendations and educational guidance targeted at academia and industry researchers seeking to perform translational research
Guidelines for the development of reference valuesDocument describing guidelines on how to create reference values methodology statistical considerations workflows applied to transcriptomic proteomic and metabolomic studies
Alliance of Medical RI position paper on Personalised MedicineThe paper will describe joint positions of three medical Research Infrastructures (BBMRI, EATRIS, ECRIN) on key aspects of personalised medicine research.
Quality criteria for global expansion of the repository of multi-omic reference valuesDocument describing the quality assessment criteria for developing reference values for omic technologies indicating the process of sample management, sample analysis, use of reference materials and sample number
Report on sample analysisThe document will report on the outcomes of the sample analysis, using individual omics techniques and data outputs
Two joint position papers in collaboration with international partnersPosition papers will be co-authored with partners from Translation Together initiative and address global issues in translational medicine and personalised medicine areas.
Eligibility criteria for EATRIS Quality CertificateDocument describing criteria and the rationale behind necessary for accessing the stamp of EATRIS quality certificate
Position paper: regulatory bottlenecks in Personalised MedicineThe position paper will describe the regulatory hurdles that hinder the progress of personalised medicine products and treatments
Report describing the EATRIS-Plus FAIRification template and workflowsDocument presenting the criteria necessary to implement FAIRification of multiomic data Descriptions of the operational steps to ensure proper data management under the FAIR principles
Curriculum Summer SchoolThe document will describe the learning objectives and programme of the first edition of the Summer School of Translational Medicine organised by INFARMED.
Patient involvement toolkit for translational researchersThe toolkit will include guidelines and concrete tools for translational researchers who want to involve patients in their research.
Curricula e-learning modules TransMed AcademyThis deliverable will compile the curricula of the elearning modules developed in the project and made available on the online environment of EATRIS TRANSMED Academy
Results survey biotech/SME needs and services gapsThe document will summarise the results of a survey carried out by BIOCAT towards European biotech and SMEs about to their infrastructure needs in the field of medicines development.
Report on the evaluation of methods for improving comparability of cross-omics data from different cohortsDocument describing the process for assessment of the methodology for exchanging omic data when developing cross-omic studies.
Joint EPF-EATRIS position paperThe position paper will highlight joint positions of EPF and EATRIS on how to strengthen patient involvement in translational research and the role medical research infrastructures such as EATRIS can play in this co-creation process.
Publication of results of ring testing activityScientific paper reporting the results of the ring testing programme
Publications
Auteurs:
"""Oldoni E, Saunders G, Bietrix F, Garcia Bermejo ML, Niehues A, 't Hoen PAC,
Nordlund J, Hajduch M, Scherer A, Kivinen K, Pitkänen E, Mäkela TP, Gut I,
Scollen S, Kozera Ł, Esteller M, Shi L, Ussi A, Andreu AL, van Gool AJ"""
Publié dans:
Frontiers in Molecular Bioscience, Numéro Volume 9 - 2022, 2022, ISSN 2296-889X
Éditeur:
Frontiers
DOI:
10.3389/fmolb.2022.974799
Auteurs:
Casper de Visser,Lennart F. Johansson,Purva Kulkarni,Hailiang Mei,Pieter Neerincx,K. Joeri van der Velde,Péter Horvatovich,Alain J. van Gool,Morris A. Swertz,Peter A. C. ‘t Hoen ,Anna Niehues
Publié dans:
PLoS Comput Biol, Numéro 2023 Sep 28;19(9):e1011369, 2023, ISSN 1553-7358
Éditeur:
PLOS
DOI:
10.1371/journal.pcbi.1011369
Auteurs:
Capone F, Morrow D, Moretti F.
Publié dans:
The International Journal of Biological Markers, Numéro 2023;38(2):, 2023, Page(s) 77-80, ISSN 0393-6155
Éditeur:
Wichtig Editore
DOI:
10.1177/03936155231179981
Auteurs:
Anna Niehues, Casper de Visser, Fiona A Hagenbeek, Purva Kulkarni, René Pool, Naama Karu, Alida S D Kindt, Gurnoor Singh, Robert R J M Vermeiren, Dorret I Boomsma, Jenny van Dongen, Peter A C ’t Hoen, Alain J van Gool
Publié dans:
GigaScience, Numéro Volume 13, 2024, giad115, 2023, ISSN 2047-217X
Éditeur:
Giga Science Press (Oxford Academic)
DOI:
10.1093/gigascience/giad115
Auteurs:
Kanny K. Wan, Danielle Davis, Taylor N. Lee, Stephanie L. Ford-Scheimer, Antonio L. Andreu, Florence Bietrix, Justin Bryans, Marco T. Castro, Nobuyoshi Chiba, Jessica M. Faupel-Badger, Brittany Haynes, Ryutaro Hirasawa, Carlos M. Morel, Thiago Moreno L. Souza, David Morrow, Trent Munro, Stuart Newman, Anton E. Ussi, Poliana B. Zorzal, Matthew D. Hall, Donald C. Lo & Christine M. Cutillo
Publié dans:
Nature Reviews Drug Discovery, 2022, ISSN 1474-1784
Éditeur:
Springer Nature Limited
DOI:
10.1038/d41573-022-00020-6
Auteurs:
Niehues, A., Bizzarri, D., Reinders, M.J. et al.
Publié dans:
BMC Genomics, Numéro volume 23, Article number: 546 (2022), 2022, ISSN 1471-2164
Éditeur:
BioMed Central
DOI:
10.1186/s12864-022-08771-7
Auteurs:
K. Joeri van der Velde; Gurnoor Singh; Rajaram Kaliyaperumal; XiaoFeng Liao; Sander de Ridder; Susanne Rebers; Hindrik H. D. Kerstens; Fernanda de Andrade; Jeroen van Reeuwijk; Fini E. De Gruyter; Saskia Hiltemann; Maarten Ligtvoet; Marjan M. Weiss; Hanneke W. M. van Deutekom; Anne M. L. Jansen; Andrew P. Stubbs; Lisenka E. L. M. Vissers; Jeroen F. J. Laros; Esther van Enckevort; Daphne Stemkens;
Publié dans:
Scientific Data, Numéro 12, 2022, ISSN 2052-4463
Éditeur:
Nature Scientific Data
DOI:
10.1038/s41597-022-01265-x
Auteurs:
Ondrej Bouska; Hana Jaworek; Vladimira Koudelakova; Katerina Kubanova; Petr Dzubak; Rastislav Slavkovsky; Branislav Siska; Petr Pavlis; Jana Vrbkova; Marian Hajduch
Publié dans:
Viruses; Volume 14; Numéro 12; Pages: 2829, Numéro 7, 2022, ISSN 1999-4915
Éditeur:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/v14122829
Auteurs:
Yana Danailova,Tsvetelina Velikova,Georgi Nikolaev,Zorka Mitova ,Alexander Shinkov,Hristo Gagov, Rossitza Konakchieva
Publié dans:
International Journal of Molecular Sciences, Numéro 2022, 23(9), 5144, 2022, ISSN 1422-0067
Éditeur:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms23095144
Auteurs:
Francis E. Agamah, Jumamurat R. Bayjanov, Anna Niehues, Kelechi F. Njoku, Michelle Skelton, Gaston K. Mazandu, Thomas H. A. Ederveen, Nicola Mulder, Emile R. Chimusa, Peter A. C. 't Hoen
Publié dans:
Frontiers in Molecular Biosciences, Numéro Volume 9 - 2022, 2022, ISSN 2296-889X
Éditeur:
Frontiers
DOI:
10.3389/fmolb.2022.967205
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