Project description
An enlightened monitoring system reduces risks associated with localised radiotherapy
The ability to deliver medicine exactly where it is needed typically results in more effective treatment at lower doses with fewer side-effects than treatments with lower spatial or temporal resolution. Just as a nasal inhaler works on this principle, radiation to treat cancer has benefited from increasingly localised administration through brachytherapy (placing encapsulated radioactive material inside the body in the area of cancerous tissue). Given that radiation can have much more serious side-effects on healthy cells than a nasal inhalant, clinicians monitor its administration in real-time. The EU-funded ORIGIN project is developing a vastly improved methodology, a photonics-based optical dose imaging and localisation system whose resolution will significantly reduce the overall risk of treatment error.
Objective
ORIGIN aims to deliver more effective, photonics-enabled, brachytherapy for cancer treatment through advanced real-time radiation dose imaging and source localisation. This will be achieved by the development of a new optical fibre based sensor system to support diagnostics-driven therapy through enhanced adaptive brachytherapy. A 16-point optical fibre sensors system will be developed, for Low Dose Rate (LDR) and High Dose Rate (HDR) Brachytherapy, with sensitivity of 150 counts/Gy for LDR- and 2500 counts/mGy for HDR- BT alongside a dedicated data acquisition system providing a dose mapping system with a spatial resolution of 0.5mm (HDR) and 3mm (LDR) and time resolution of 0.1s (HDR) and 0.5s (LDR), with 5% uncertainty. This is a 50% improvement in uncertainty over existing systems. Further interrogation of the optical signal will provide real-time monitoring of the radiation source location during treatment. The ORIGIN system will be integrated into existing clinical brachytherapy treatment planning and delivery systems to confirm that the dose prescribed to the tumour is achieved, whilst ensuring the dose to organs at risk (OARs) is within acceptable limits. This will provide for optimised dose-led, patient-oriented, personalised treatment plans leading to improved patient outcomes and prevention of treatment errors, with the potential to reduce the overall risk of treatment error by 55%. The optical fibre radiation dosimeters will be further optimised for improved optical signal collection efficiency, higher signal-to-noise ratio (SNR) and repeatable high volume fabrication. Taking manufacturability into consideration from the outset will ensure that ORIGIN establishes Europe at the fore of brachytherapy system development and photonics manufacturing.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- medical and health sciences clinical medicine oncology
- natural sciences physical sciences optics fibre optics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.2.1.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
RIA - Research and Innovation action
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-ICT-2018-20
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
- Limerick
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.