Nanopeptides and Nanosaccharides for Advanced and Sustainable Materials

Deliverables

Seminars held at industries and SME.
Training young scientist on experimental methods for studying tumor adipogenic reprogramming by using nanoparticles

Training young scientist on experimental methods for studying tumor adipogenic reprogramming by using nanoparticles and advanced microscopy techniques

Training ESR on experimental methods

Training ESR on experimental methods for engineering and characterization of PG NPs

Training ESR on theoretical modelling

Training ESR on theoretical modelling and machine learning methods for water based organic NPs

Training young scientists on experimental methods for studying the physico-chemical properties of PG-PNIPAM

Training young scientists on experimental methods for studying the physico-chemical properties of PG-PNIPAM, including AFM and microscopy

"Lecture notes on ""Role of mechanotransduction systems during stem cell differentiation"" and Advanced microscopy for protein tracking"

Lecture notes on Role of mechanotransduction systems during stem cell differentiation and Advanced microscopy for protein tracking

Lecture notes on peptide nanochemistry and ultrasonic technologies.

Lecture notes on peptide nanochemistry and ultrasonic technologies

"Lecture notes on ""rationale design of nanocarriers for biomedical applications"

Lecture notes on rationale design of nanocarriers for biomedical applications

Lecture notes on synthesis of hybrid polymerics materials and microfluidic techniques

Lecture notes on synthesis of hybrid polymerics materials and microfluidic techniques to synthesize microparticles

Training young scientist on different experimental approaches

Training young scientist on different experimental approaches ultrasonic techniques selfassembly LangmuirBlodgett for obtaining peptide nanostructures

Training young scientists on experimental methods for PG-PNIPAM preparation.

Curriculum of interdisciplinary studies on innovation strategies
A set of self-assembling and sono-responsive peptide building blocks.

A set of selfassembling and sonoresponsive peptide building blocks

A library of engineered, functional and versatile PG NPs

A library of engineered functional and versatile PG NPs with controlled properties that can be deployed for various applications

Definition of the best conditions to induce tumor cell cycle and migration arrest by NPs
Submitted grant proposals to European Community, NSF and NIH (USA), ARC.
Definition of conditions to induce tumor adipogenic reprogramming by NPs

Definition of conditions to induce tumor adipogenic reprogramming by NPs.

A collection of training materials and experiences on co-creation and citizen/stakeholder engagement for seconded ER/ESRs working in the field of nanoscience and nanotechnology
Nanopeptides with well-defined size, morphology and electroactive properties

Nanopeptides with welldefined size and morphology and electroactive peptidelipid films for biosensing

Complete the synthesis and characterization of PG-PNIPAM bioplastics and nanogels

Complete the synthesis and characterization of PGPNIPAM bioplastics and nanogels

Report on design rules for PG NPs

Report on design rules for PG NPs with tuneable programmable properties

A collection of Virtual Reality products

A collection of Virtual Reality products for disseminating and visualizing the complex results and concepts of the research within PEPSA-MATE.

Publications

Alginate Microsponges as a Scaffold for Delivery of a Therapeutic Peptide against Rheumatoid Arthritis

Author(s): Daniela Ariaudo, Francesca Cavalieri, Antonio Rinaldi, Ana Aguilera, Matilde Lopez, Hilda Garay Perez, Ariel Felipe, Maria del Carmen Dominguez, Odalys Ruiz, Gillian Martinez, Mariano Venanzi
Published in: Nanomaterials, Issue 13, 2023, Page(s) 2709, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano13192709

An approach to characterize the nanolayer for a nanofluid: Thickness, density and molar mass

Author(s): T.P. Iglesias, A. Queirós, M.F. Coelho
Published in: Journal of Molecular Liquids, Issue 393, 2024, Page(s) 123537, ISSN 0167-7322
Publisher: Elsevier BV
DOI: 10.1016/j.molliq.2023.123537

Formulation matters! A spectroscopic and molecular dynamics investigation on the peptide CIGB552 as itself and in its therapeutical formulation.

Author(s): M Savioli, L Antonelli, G Bocchinfuso, F Cavalieri, R Cimino, E Gatto et al.
Published in: Journal of Peptide Science, 2022, Page(s) 28: e3356, ISSN 1099-1387
Publisher: Wiley
DOI: 10.1002/psc.3356

Tuning Peptide-Based Hydrogels: Co-Assembly with Composites Driving the Highway to Technological Applications

Author(s): Valéria Gomes; Sérgio R. S. Veloso; Miguel A. Correa-Duarte; Paula M. T. Ferreira; Elisabete M. S. Castanheira
Published in: International Journal of Molecular Sciences, Issue 1, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24010186

Hybrid phytoglycogen-dopamine nanoparticles as biodegradable underwater adhesives

Author(s): Jiayi Liu, Dmitrii Sychev, Nadiia Davydiuk, Mahmoud Al-Hussein, Andreas Fery, Quinn A. Besford
Published in: Soft Matter, Issue 21, 2025, Page(s) 2282-2290, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4sm01454e

Aggregation properties of a therapeutic peptide for rheumatoid arthritis: A spectroscopic and molecular dynamics study.

Author(s): Rita Cimino, Marco Savioli, Noemi Ferrante Carrante, Ernesto Placidi, Hilda Garay-Perez, Matilde López-Abad, Alexis Musacchio Lasa, Maria Del Carmen Domínguez-Horta, Emanuela Gatto, Francesca Cavalieri, Gianfranco Bocchinfuso, Mariano Venanzi
Published in: ChemPhysMater, 2022, Page(s) 1, 62-70., ISSN 2772-5715
Publisher: KeAi
DOI: 10.1016/j.chphma.2021.09.007

Peptide Self-Assembled Nanostructures: from Models to Therapeutic Peptides

Author(s): Emanuela Gatto, Claudio Toniolo and Mariano Venanz
Published in: Nanomaterials, 2022, Page(s) 12(3), 466;, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano12030466

An Engineered Nanosugar Enables Rapid and SustainedGlucose-Responsive Insulin Delivery in Diabetic Mice

Author(s): Rong Xu, Sukhvir Kaur Bhangu, Karly C. Sourris, Domitilla Vanni, Marc-Antoine Sani, John A. Karas, Karen Alt, Be’eri Niego, Anukreity Ale, Quinn A. Besford, Brendan Dyett, Joshua Patrick, Irena Carmichael, Jonathan E. Shaw, Frank Caruso, Mark E. Cooper, Christoph E. Hagemeyer,* and Francesca Cavalieri*
Published in: Advanced Materials, 2023, ISSN 1521-4095
Publisher: Wiley
DOI: 10.1002/adma.202210392

Magnetically propelled chained nanocomposites for biologically relevant media exploration

Author(s): Miguel A. Ramos-Docampo; Pablo Hurtado; Ana B. Dávila-Ibáñez; Roberto Piñeiro; Mónica L. Fanarraga; Verónica Salgueiriño
Published in: J Colloid Interface Sci . Volume 629, Part A, January 2023, Pages 287-296, Issue 1, 2023, ISSN 0021-9797
Publisher: Academic Press
DOI: 10.1016/j.jcis.2022.08.154

Antibody-Free Glycogen Nanoparticles Engage Human Immune T Cells for Intracellular Delivery of Small Drugs or mRNA

Author(s): Soraia Fernandes, Miriam Quattrociocchi, Marco Cassani, Giulio Savazzi, Darryl Johnson, Giancarlo Forte, Frank Caruso, Francesca Cavalieri
Published in: ACS Nano, Issue 18, 2024, Page(s) 28910-28923, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.4c09156

A spectroscopic and molecular dynamics study on the aggregation process of a long-acting lipidated therapeutic peptide: the case of semaglutide

Author(s): Mariano Venanzi; Marco Savioli; Rita Cimino; Emanuela Gatto; Antonio Palleschi; Giorgio Ripani; Daniel Oscar Cicero; Ernesto Placidi; F. Orvieto; E. Bianchi
Published in: Soft Matter, Issue 3, 2020, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sm01011a

Electrochemical immunosensor for antibody recognition against SARS-CoV-2 B-cell epitope: impact of RBD mutations on antigen–antibody binding

Author(s): Freddy A. Nunez, Vivian L. de Oliveira, Cesar Remuzgo, Marcos R. de A. Silva, Isabela Daher, Jamille R. Oliveira, Tamires L. Silva, Edecio Cunha-Neto, Jorge Kalil, Keity S. Santos, Quinn A. Besford, Wendel A. Alves
Published in: Journal of Materials Chemistry B, Issue 13, 2025, Page(s) 9925-9936, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/d5tb00630a

Magnetism Engineering in Antiferromagnetic β-FeOOH Nanostructures via Chemically Induced Lattice Defects

Author(s): Martín Testa-Anta*, Ecem Tiryaki, Laura Bocher, and Verónica Salgueiriño
Published in: Chemistry of Materials, Issue 2, 2023, ISSN 0897-4756
Publisher: American Chemical Society
DOI: 10.1021/acs.chemmater.2c03067

Triggering the nanophase separation of albumin through multivalent binding to glycogen for drug delivery in 2D and 3D multicellular constructs.

Author(s): Agata Glab, Sukhvir Kaur Bhangu, Soraia Fernandes, Christina Cortez-Jugo, Robert De Rose, Brendan Dyett, Marcin Wojnilowicz, Petra Laznickova, Jan Fric, Giancarlo Forte, Frank Caruso*, Francesca Cavalieri*
Published in: Nanoscale, 2022, Page(s) 14, 3452-3466, ISSN 2040-3372
Publisher: RCS
DOI: 10.1039/d1nr08429a

Emerging Strategies for Immunotherapy of Solid Tumors Using Lipid‐Based Nanoparticles

Author(s): Soraia Fernandes, Marco Cassani, Francesca Cavalieri, Giancarlo Forte, Frank Caruso
Published in: Advanced Science, Issue 11, 2024, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202305769

Application of Microsponge Drug Platform to Enhance Methotrexate Administration in Rheumatoid Arthritis Therapy

Author(s): Noemi Fiaschini, Patrizia Nadia Hanieh, Daniela Ariaudo, Rita Cimino, Carlo Abbate, Elena Romano, Francesca Cavalieri, Mariano Venanzi, Valeria Palumbo, Manuel Scimeca, Roberta Bernardini, Maurizio Mattei, Alberto Migliore, Antonio Rinaldi
Published in: Pharmaceutics, Issue 16, 2024, Page(s) 1593, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16121593

Interfaceless Exchange Bias in CoFe2O4 Nanocrystals

Author(s): Beatriz Rivas-Murias; Martín Testa-Anta; Alexander S. Skorikov; Miguel Comesaña-Hermo; Sara Bals; Verónica Salgueiriño
Published in: Nano Letters, Issue 4, 2023, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.2c04268

Supramolecular Assembly of Polyphenols and Nucleic Acids by Thermal Cycling for Immune Cell Activation

Author(s): Yijiao Qu, Haiyan Zhu, Zhixing Lin, Domitilla Vanni, Sukhvir Kaur Bhangu, Brendan Dyett, Marc-Antoine Sani, Christina Cortez-Jugo, Frank Caruso, Francesca Cavalieri
Published in: Chemistry of Materials, Issue 35, 2023, Page(s) 7103-7112, ISSN 0897-4756
Publisher: American Chemical Society
DOI: 10.1021/acs.chemmater.3c01378

Synergistic Interaction of Clusters of Iron Oxide Nanoparticles and Reduced Graphene Oxide for High Supercapacitor Performance

Author(s): Amir Elsaidy, Julia N. Majcherkiewicz, Begoña Puértolas, Verónica Salgueiriño, Xosé Ramón Nóvoa, Miguel A. Correa-Duarte
Published in: Nanomaterials, Issue 12, 2024, Page(s) 2695, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano12152695

Room Temperature Spin‐Phonon Coupling in Cr2O3 Nanocrystals

Author(s): Martín Testa‐Anta, Julia N. Majcherkiewicz, Kai Xu, Alejandro R. Goñi, Verónica Salgueiriño
Published in: Advanced Functional Materials, Issue 33, 2023, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202301973

Approximation for determining the effective nanolayer thickness in nanofluids of spherical nanoparticles through permittivity

Author(s): T.P. Iglesias, A. Queirós, M.F. Coelho
Published in: Journal of Molecular Liquids, Issue 427, 2025, Page(s) 127376, ISSN 0167-7322
Publisher: Elsevier BV
DOI: 10.1016/j.molliq.2025.127376

The interaction of glycogen nanoparticles with human blood

Author(s): Nadiia Davydiuk, Vaidehi Londhe, Manfred F. Maitz, Carsten Werner, Andreas Fery, Quinn A. Besford
Published in: Nanoscale, Issue 17, 2024, Page(s) 252-260, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4nr03034f

Programming an Enhanced Uptake and the Intracellular Fate of Magnetic Microbeads

Author(s): Ecem Tiryaki, Saida Ortolano, Gustavo Bodelón, Verónica Salgueiriño
Published in: Advanced Healthcare Materials, Issue 12, 2023, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202301415

Oxidative Precipitation Synthesis of Calcium-Doped Manganese Ferrite Nanoparticles for Magnetic Hyperthermia

Author(s): Sérgio R. S. Veloso , Raquel G. D. Andrade , Valéria Gomes , Carlos O. Amorim , Vítor S. Amaral , Verónica Salgueiriño , Paulo J. G. Coutinho , Paula M. T. Ferreira , Miguel A. Correa-Duarte and Elisabete M. S. Castanheira
Published in: International Journal of Molecular Sciences, Issue 2, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232214145

Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels

Author(s): Sérgio R. S. Velosoa, Ecem Tiryakib, Carlos Spuchc, Loic Hillioud, C. O. Amorime, V. S. Amarale, Paulo J. G. Coutinhoa, Paula M. T. Ferreiraf, Verónica Salgueiriñob,g*, Miguel A. Correa-Duarteg,*, and Elisabete M. S. Castanheiraa,*
Published in: Nanoscale, Issue 1, 2022, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/D1NR08158F

Chitosan/Alginate Nanogels Containing Multicore Magnetic Nanoparticles for Delivery of Doxorubicin

Author(s): Sérgio R. S. Veloso, Eva S. Marta, Pedro V. Rodrigues, Cacilda Moura, Carlos O. Amorim, Vítor S. Amaral, Miguel A. Correa-Duarte, Elisabete M. S. Castanheira
Published in: Pharmaceutics, Issue 15, 2023, Page(s) 2194, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15092194

Unraveling the Role of the Tumor Extracellular Matrix to Inform Nanoparticle Design for Nanomedicine

Author(s): Marco Cassani, Soraia Fernandes, Stefania Pagliari, Francesca Cavalieri, Frank Caruso, Giancarlo Forte
Published in: Advanced Science, Issue 12, 2025, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202409898

Deliverables

Publications

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