Nanopeptides and Nanosaccharides for Advanced and Sustainable Materials

Informations projet

PEPSA-MATE

N° de convention de subvention: 872233

DOI

10.3030/872233

Projet clôturé

Date de signature de la CE 24 Septembre 2019

Date de début 1 Mars 2020

Date de fin 31 Août 2025

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 1 232 800,00

Contribution de l’UE

€ 961 400,00

Coordonné par

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Other (11)

Seminars held at industries and SME.
Training young scientist on experimental methods for studying tumor adipogenic reprogramming by using nanoparticles

Training young scientist on experimental methods for studying tumor adipogenic reprogramming by using nanoparticles and advanced microscopy techniques

Training ESR on experimental methods

Training ESR on experimental methods for engineering and characterization of PG NPs

Training ESR on theoretical modelling

Training ESR on theoretical modelling and machine learning methods for water based organic NPs

Training young scientists on experimental methods for studying the physico-chemical properties of PG-PNIPAM

Training young scientists on experimental methods for studying the physico-chemical properties of PG-PNIPAM, including AFM and microscopy

"Lecture notes on ""Role of mechanotransduction systems during stem cell differentiation"" and Advanced microscopy for protein tracking"

Lecture notes on Role of mechanotransduction systems during stem cell differentiation and Advanced microscopy for protein tracking

Lecture notes on peptide nanochemistry and ultrasonic technologies.

Lecture notes on peptide nanochemistry and ultrasonic technologies

"Lecture notes on ""rationale design of nanocarriers for biomedical applications"

Lecture notes on rationale design of nanocarriers for biomedical applications

Lecture notes on synthesis of hybrid polymerics materials and microfluidic techniques

Lecture notes on synthesis of hybrid polymerics materials and microfluidic techniques to synthesize microparticles

Training young scientist on different experimental approaches

Training young scientist on different experimental approaches ultrasonic techniques selfassembly LangmuirBlodgett for obtaining peptide nanostructures

Training young scientists on experimental methods for PG-PNIPAM preparation.

Documents, reports (10)

Curriculum of interdisciplinary studies on innovation strategies
A set of self-assembling and sono-responsive peptide building blocks.

A set of selfassembling and sonoresponsive peptide building blocks

A library of engineered, functional and versatile PG NPs

A library of engineered functional and versatile PG NPs with controlled properties that can be deployed for various applications

Definition of the best conditions to induce tumor cell cycle and migration arrest by NPs
Submitted grant proposals to European Community, NSF and NIH (USA), ARC.
Definition of conditions to induce tumor adipogenic reprogramming by NPs

Definition of conditions to induce tumor adipogenic reprogramming by NPs.

A collection of training materials and experiences on co-creation and citizen/stakeholder engagement for seconded ER/ESRs working in the field of nanoscience and nanotechnology
Nanopeptides with well-defined size, morphology and electroactive properties

Nanopeptides with welldefined size and morphology and electroactive peptidelipid films for biosensing

Complete the synthesis and characterization of PG-PNIPAM bioplastics and nanogels

Complete the synthesis and characterization of PGPNIPAM bioplastics and nanogels

Report on design rules for PG NPs

Report on design rules for PG NPs with tuneable programmable properties

Websites, patent fillings, videos etc. (1)

A collection of Virtual Reality products

A collection of Virtual Reality products for disseminating and visualizing the complex results and concepts of the research within PEPSA-MATE.

Publications

Peer reviewed articles (27)

Alginate Microsponges as a Scaffold for Delivery of a Therapeutic Peptide against Rheumatoid Arthritis

Auteurs: Daniela Ariaudo, Francesca Cavalieri, Antonio Rinaldi, Ana Aguilera, Matilde Lopez, Hilda Garay Perez, Ariel Felipe, Maria del Carmen Dominguez, Odalys Ruiz, Gillian Martinez, Mariano Venanzi
Publié dans: Nanomaterials, Numéro 13, 2023, Page(s) 2709, ISSN 2079-4991
Éditeur: MDPI
DOI: 10.3390/nano13192709

An approach to characterize the nanolayer for a nanofluid: Thickness, density and molar mass

Auteurs: T.P. Iglesias, A. Queirós, M.F. Coelho
Publié dans: Journal of Molecular Liquids, Numéro 393, 2024, Page(s) 123537, ISSN 0167-7322
Éditeur: Elsevier BV
DOI: 10.1016/j.molliq.2023.123537

Formulation matters! A spectroscopic and molecular dynamics investigation on the peptide CIGB552 as itself and in its therapeutical formulation.

Auteurs: M Savioli, L Antonelli, G Bocchinfuso, F Cavalieri, R Cimino, E Gatto et al.
Publié dans: Journal of Peptide Science, 2022, Page(s) 28: e3356, ISSN 1099-1387
Éditeur: Wiley
DOI: 10.1002/psc.3356

Tuning Peptide-Based Hydrogels: Co-Assembly with Composites Driving the Highway to Technological Applications

Auteurs: Valéria Gomes; Sérgio R. S. Veloso; Miguel A. Correa-Duarte; Paula M. T. Ferreira; Elisabete M. S. Castanheira
Publié dans: International Journal of Molecular Sciences, Numéro 1, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24010186

Hybrid phytoglycogen-dopamine nanoparticles as biodegradable underwater adhesives

Auteurs: Jiayi Liu, Dmitrii Sychev, Nadiia Davydiuk, Mahmoud Al-Hussein, Andreas Fery, Quinn A. Besford
Publié dans: Soft Matter, Numéro 21, 2025, Page(s) 2282-2290, ISSN 1744-683X
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d4sm01454e

Aggregation properties of a therapeutic peptide for rheumatoid arthritis: A spectroscopic and molecular dynamics study.

Auteurs: Rita Cimino, Marco Savioli, Noemi Ferrante Carrante, Ernesto Placidi, Hilda Garay-Perez, Matilde López-Abad, Alexis Musacchio Lasa, Maria Del Carmen Domínguez-Horta, Emanuela Gatto, Francesca Cavalieri, Gianfranco Bocchinfuso, Mariano Venanzi
Publié dans: ChemPhysMater, 2022, Page(s) 1, 62-70., ISSN 2772-5715
Éditeur: KeAi
DOI: 10.1016/j.chphma.2021.09.007

Peptide Self-Assembled Nanostructures: from Models to Therapeutic Peptides

Auteurs: Emanuela Gatto, Claudio Toniolo and Mariano Venanz
Publié dans: Nanomaterials, 2022, Page(s) 12(3), 466;, ISSN 2079-4991
Éditeur: MDPI
DOI: 10.3390/nano12030466

An Engineered Nanosugar Enables Rapid and SustainedGlucose-Responsive Insulin Delivery in Diabetic Mice

Auteurs: Rong Xu, Sukhvir Kaur Bhangu, Karly C. Sourris, Domitilla Vanni, Marc-Antoine Sani, John A. Karas, Karen Alt, Be’eri Niego, Anukreity Ale, Quinn A. Besford, Brendan Dyett, Joshua Patrick, Irena Carmichael, Jonathan E. Shaw, Frank Caruso, Mark E. Cooper, Christoph E. Hagemeyer,* and Francesca Cavalieri*
Publié dans: Advanced Materials, 2023, ISSN 1521-4095
Éditeur: Wiley
DOI: 10.1002/adma.202210392

Magnetically propelled chained nanocomposites for biologically relevant media exploration

Auteurs: Miguel A. Ramos-Docampo; Pablo Hurtado; Ana B. Dávila-Ibáñez; Roberto Piñeiro; Mónica L. Fanarraga; Verónica Salgueiriño
Publié dans: J Colloid Interface Sci . Volume 629, Part A, January 2023, Pages 287-296, Numéro 1, 2023, ISSN 0021-9797
Éditeur: Academic Press
DOI: 10.1016/j.jcis.2022.08.154

Antibody-Free Glycogen Nanoparticles Engage Human Immune T Cells for Intracellular Delivery of Small Drugs or mRNA

Auteurs: Soraia Fernandes, Miriam Quattrociocchi, Marco Cassani, Giulio Savazzi, Darryl Johnson, Giancarlo Forte, Frank Caruso, Francesca Cavalieri
Publié dans: ACS Nano, Numéro 18, 2024, Page(s) 28910-28923, ISSN 1936-0851
Éditeur: American Chemical Society
DOI: 10.1021/acsnano.4c09156

A spectroscopic and molecular dynamics study on the aggregation process of a long-acting lipidated therapeutic peptide: the case of semaglutide

Auteurs: Mariano Venanzi; Marco Savioli; Rita Cimino; Emanuela Gatto; Antonio Palleschi; Giorgio Ripani; Daniel Oscar Cicero; Ernesto Placidi; F. Orvieto; E. Bianchi
Publié dans: Soft Matter, Numéro 3, 2020, ISSN 1744-683X
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0sm01011a

Electrochemical immunosensor for antibody recognition against SARS-CoV-2 B-cell epitope: impact of RBD mutations on antigen–antibody binding

Auteurs: Freddy A. Nunez, Vivian L. de Oliveira, Cesar Remuzgo, Marcos R. de A. Silva, Isabela Daher, Jamille R. Oliveira, Tamires L. Silva, Edecio Cunha-Neto, Jorge Kalil, Keity S. Santos, Quinn A. Besford, Wendel A. Alves
Publié dans: Journal of Materials Chemistry B, Numéro 13, 2025, Page(s) 9925-9936, ISSN 2050-7518
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d5tb00630a

Magnetism Engineering in Antiferromagnetic β-FeOOH Nanostructures via Chemically Induced Lattice Defects

Auteurs: Martín Testa-Anta*, Ecem Tiryaki, Laura Bocher, and Verónica Salgueiriño
Publié dans: Chemistry of Materials, Numéro 2, 2023, ISSN 0897-4756
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemmater.2c03067

Triggering the nanophase separation of albumin through multivalent binding to glycogen for drug delivery in 2D and 3D multicellular constructs.

Auteurs: Agata Glab, Sukhvir Kaur Bhangu, Soraia Fernandes, Christina Cortez-Jugo, Robert De Rose, Brendan Dyett, Marcin Wojnilowicz, Petra Laznickova, Jan Fric, Giancarlo Forte, Frank Caruso*, Francesca Cavalieri*
Publié dans: Nanoscale, 2022, Page(s) 14, 3452-3466, ISSN 2040-3372
Éditeur: RCS
DOI: 10.1039/d1nr08429a

Emerging Strategies for Immunotherapy of Solid Tumors Using Lipid‐Based Nanoparticles

Auteurs: Soraia Fernandes, Marco Cassani, Francesca Cavalieri, Giancarlo Forte, Frank Caruso
Publié dans: Advanced Science, Numéro 11, 2024, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.202305769

Application of Microsponge Drug Platform to Enhance Methotrexate Administration in Rheumatoid Arthritis Therapy

Auteurs: Noemi Fiaschini, Patrizia Nadia Hanieh, Daniela Ariaudo, Rita Cimino, Carlo Abbate, Elena Romano, Francesca Cavalieri, Mariano Venanzi, Valeria Palumbo, Manuel Scimeca, Roberta Bernardini, Maurizio Mattei, Alberto Migliore, Antonio Rinaldi
Publié dans: Pharmaceutics, Numéro 16, 2024, Page(s) 1593, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16121593

Interfaceless Exchange Bias in CoFe₂O₄ Nanocrystals

Auteurs: Beatriz Rivas-Murias; Martín Testa-Anta; Alexander S. Skorikov; Miguel Comesaña-Hermo; Sara Bals; Verónica Salgueiriño
Publié dans: Nano Letters, Numéro 4, 2023, ISSN 1530-6984
Éditeur: American Chemical Society
DOI: 10.1021/acs.nanolett.2c04268

Supramolecular Assembly of Polyphenols and Nucleic Acids by Thermal Cycling for Immune Cell Activation

Auteurs: Yijiao Qu, Haiyan Zhu, Zhixing Lin, Domitilla Vanni, Sukhvir Kaur Bhangu, Brendan Dyett, Marc-Antoine Sani, Christina Cortez-Jugo, Frank Caruso, Francesca Cavalieri
Publié dans: Chemistry of Materials, Numéro 35, 2023, Page(s) 7103-7112, ISSN 0897-4756
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemmater.3c01378

Synergistic Interaction of Clusters of Iron Oxide Nanoparticles and Reduced Graphene Oxide for High Supercapacitor Performance

Auteurs: Amir Elsaidy, Julia N. Majcherkiewicz, Begoña Puértolas, Verónica Salgueiriño, Xosé Ramón Nóvoa, Miguel A. Correa-Duarte
Publié dans: Nanomaterials, Numéro 12, 2024, Page(s) 2695, ISSN 2079-4991
Éditeur: MDPI
DOI: 10.3390/nano12152695

Room Temperature Spin‐Phonon Coupling in Cr₂O₃ Nanocrystals

Auteurs: Martín Testa‐Anta, Julia N. Majcherkiewicz, Kai Xu, Alejandro R. Goñi, Verónica Salgueiriño
Publié dans: Advanced Functional Materials, Numéro 33, 2023, ISSN 1616-301X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202301973

Approximation for determining the effective nanolayer thickness in nanofluids of spherical nanoparticles through permittivity

Auteurs: T.P. Iglesias, A. Queirós, M.F. Coelho
Publié dans: Journal of Molecular Liquids, Numéro 427, 2025, Page(s) 127376, ISSN 0167-7322
Éditeur: Elsevier BV
DOI: 10.1016/j.molliq.2025.127376

The interaction of glycogen nanoparticles with human blood

Auteurs: Nadiia Davydiuk, Vaidehi Londhe, Manfred F. Maitz, Carsten Werner, Andreas Fery, Quinn A. Besford
Publié dans: Nanoscale, Numéro 17, 2024, Page(s) 252-260, ISSN 2040-3364
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d4nr03034f

Programming an Enhanced Uptake and the Intracellular Fate of Magnetic Microbeads

Auteurs: Ecem Tiryaki, Saida Ortolano, Gustavo Bodelón, Verónica Salgueiriño
Publié dans: Advanced Healthcare Materials, Numéro 12, 2023, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202301415

Oxidative Precipitation Synthesis of Calcium-Doped Manganese Ferrite Nanoparticles for Magnetic Hyperthermia

Auteurs: Sérgio R. S. Veloso , Raquel G. D. Andrade , Valéria Gomes , Carlos O. Amorim , Vítor S. Amaral , Verónica Salgueiriño , Paulo J. G. Coutinho , Paula M. T. Ferreira , Miguel A. Correa-Duarte and Elisabete M. S. Castanheira
Publié dans: International Journal of Molecular Sciences, Numéro 2, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232214145

Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels

Auteurs: Sérgio R. S. Velosoa, Ecem Tiryakib, Carlos Spuchc, Loic Hillioud, C. O. Amorime, V. S. Amarale, Paulo J. G. Coutinhoa, Paula M. T. Ferreiraf, Verónica Salgueiriñob,g*, Miguel A. Correa-Duarteg,*, and Elisabete M. S. Castanheiraa,*
Publié dans: Nanoscale, Numéro 1, 2022, ISSN 2040-3364
Éditeur: Royal Society of Chemistry
DOI: 10.1039/D1NR08158F

Chitosan/Alginate Nanogels Containing Multicore Magnetic Nanoparticles for Delivery of Doxorubicin

Auteurs: Sérgio R. S. Veloso, Eva S. Marta, Pedro V. Rodrigues, Cacilda Moura, Carlos O. Amorim, Vítor S. Amaral, Miguel A. Correa-Duarte, Elisabete M. S. Castanheira
Publié dans: Pharmaceutics, Numéro 15, 2023, Page(s) 2194, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15092194

Unraveling the Role of the Tumor Extracellular Matrix to Inform Nanoparticle Design for Nanomedicine

Auteurs: Marco Cassani, Soraia Fernandes, Stefania Pagliari, Francesca Cavalieri, Frank Caruso, Giancarlo Forte
Publié dans: Advanced Science, Numéro 12, 2025, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.202409898