Project description DEENESFRITPL ncRNAs in the fight against cancer Non-coding RNAs (ncRNAs) regulate gene expression, and there is increasing evidence that they may be implicated in cancer development and progression. With this in mind, scientists of the EU-funded cONCReTE project will work under the hypothesis that tumour-associated ncRNAs may serve as targets for cancer therapy. cONCReTE will identify ncRNAs with a role in tumour biology. The key objective is to unveil novel functional links between ncRNAs and oncogenic pathways by monitoring their accumulation and impact in various cancer cell types. Project results will pave the way for the development of ncRNA-based therapeutics against cancer. Show the project objective Hide the project objective Objective Non-codingRNAs (ncRNAs) represent a large class of molecules that in concert regulate the expression of genes involved in the key pathways governing cancer development and progression. They represent ideal targets for personalized cancer therapies and if appropriately designed they can provide specific, non-toxic and effective therapeutic tools. The identification of novel therapeutic ncRNAs and the design of their appropriate formulation is a key aspect for their clinical applicability. RISE- cONCReTE aims to form an international and inter-sectoral network of organizations working on a joint research programme on the development of a safe ncRNA-based drug. RISE- cONCReTE teams up experts in the fields of Molecular Oncology, Epigenetics, Signal transduction, Animal models, Therapeutic delivery and Imaging, business, and education. The participants will exchange skills, knowledge and staff members that will be exposed to synergetic and complementary research environments. RISE- cONCReTE will undertake an integrated approach to reveal novels functional links between ncRNAs and oncogenic pathways. We will: a) characterize novel classes of tumor-associated ncRNAs; b) investigate the impact of ncRNAs on key aspects of tumor cell biology; c) develop cargoes (e.g. aptamers) for delivering therapeutic ncRNA derivatives into specific cancer cell types. By using innovative in vivo imaging tools, we will monitor the accumulation of target ncRNAs in cancer cells and evaluate their biological efficacy in inhibiting the growth and spreading of malignant tumors. The resulting approaches will provide stable and effective tools thus potentially improving the quality of life (QOL) of the cancer patients. Further, the joint research and training programme of RISE- cONCReTE will be performed in academic institutions and SME to provide a unique interdisciplinary platform for scientists with a significant contribution to EU competitiveness. Fields of science natural sciencesbiological sciencescell biologymedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticsRNAnatural sciencesbiological sciencesgeneticsepigenetics Keywords Cancer RNA Cancer Therapy Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Topic(s) MSCA-RISE-2019 - Research and Innovation Staff Exchange Call for proposal H2020-MSCA-RISE-2019 See other projects for this call Funding Scheme MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinator UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Net EU contribution € 165 600,00 Address CORSO UMBERTO I, 40 80138 Napoli Italy See on map Region Sud Campania Napoli Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 165 600,00 Participants (16) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITAET INNSBRUCK Austria Net EU contribution € 110 400,00 Address INNRAIN 52 6020 Innsbruck See on map Region Westösterreich Tirol Innsbruck Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 110 400,00 RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN Germany Net EU contribution € 110 400,00 Address REGINA PACIS WEG 3 53113 Bonn See on map Region Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 110 400,00 FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS Spain Net EU contribution € 110 400,00 Address CARRETERA DE CAN RUTI CAMI DE LES ESCOLES S/N 08916 Badalona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 110 400,00 ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands Net EU contribution € 110 400,00 Address DR MOLEWATERPLEIN 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 110 400,00 UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA Romania Net EU contribution € 110 400,00 Address VICTOR BABES STREET 8 400012 Cluj-Napoca See on map Region Macroregiunea Unu Nord-Vest Cluj Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 110 400,00 CONSIGLIO NAZIONALE DELLE RICERCHE Italy Net EU contribution € 110 400,00 Address PIAZZALE ALDO MORO 7 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 110 400,00 LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Germany Net EU contribution € 110 400,00 Address GESCHWISTER SCHOLL PLATZ 1 80539 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 110 400,00 FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA Spain Net EU contribution € 110 400,00 Address AVENIDA DE PIO XII 55 31008 Pamplona See on map Region Noreste Comunidad Foral de Navarra Navarra Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 110 400,00 PERCUROS BV Participation ended Netherlands Net EU contribution € 174 800,00 Address EERBEEKLAAN 42 2573 HT 's-Gravenhage (Den Haag) See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 174 800,00 JENACELL GMBH Germany Net EU contribution € 128 800,00 Address GOSCHWITZER STR. 22 07745 Jena See on map Region Thüringen Thüringen Jena, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 128 800,00 XENOPAT SL Spain Net EU contribution € 110 400,00 Address CALLE FEIXA LLARGA S/N EDIFICI BIOINCUOADORA 08907 Hospitalet De Llobregat See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Este Cataluña Barcelona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 110 400,00 PROGREDUM GMBH Germany Net EU contribution € 110 400,00 Address OTTERBERGER STRASSE 73 67659 Kaiserslautern See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Rheinland-Pfalz Rheinhessen-Pfalz Kaiserslautern, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 110 400,00 TACIT BIO INNOVATION LIMITED United Kingdom Net EU contribution € 119 600,00 Address BENNETT CORNER HOUSE, 33 COLESHILL STREET B72 1SD Sutton Coldfield See on map Region West Midlands (England) West Midlands Birmingham Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 119 600,00 TECOBIOSCIENCES GMBH Germany Net EU contribution € 119 600,00 Address BUSSARDSTRASSE 35 84036 Landshut See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Bayern Niederbayern Landshut, Landkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 119 600,00 CLINICA MEDITERRANEA SPA Italy Net EU contribution € 124 200,00 Address VIA ORAZIO 2 80122 Napoli See on map Region Sud Campania Napoli Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 124 200,00 ASSOCIAZIONE HAND IN HAND Participation ended Italy Net EU contribution € 124 200,00 Address VIA VITTORIO EMANUELE 32 00074 Nemi See on map Region Centro (IT) Lazio Roma Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 124 200,00