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DevelOpmeNt of Cancer RNA TherapEutics

Objective

Non-codingRNAs (ncRNAs) represent a large class of molecules that in concert regulate the expression of genes involved in the key pathways governing cancer development and progression. They represent ideal targets for personalized cancer therapies and if appropriately designed they can provide specific, non-toxic and effective therapeutic tools. The identification of novel therapeutic ncRNAs and the design of their appropriate formulation is a key aspect for their clinical applicability. RISE- cONCReTE aims to form an international and inter-sectoral network of organizations working on a joint research programme on the development of a safe ncRNA-based drug. RISE- cONCReTE teams up experts in the fields of Molecular Oncology, Epigenetics, Signal transduction, Animal models, Therapeutic delivery and Imaging, business, and education. The participants will exchange skills, knowledge and staff members that will be exposed to synergetic and complementary research environments. RISE- cONCReTE will undertake an integrated approach to reveal novels functional links between ncRNAs and oncogenic pathways. We will: a) characterize novel classes of tumor-associated ncRNAs; b) investigate the impact of ncRNAs on key aspects of tumor cell biology; c) develop cargoes (e.g. aptamers) for delivering therapeutic ncRNA derivatives into specific cancer cell types. By using innovative in vivo imaging tools, we will monitor the accumulation of target ncRNAs in cancer cells and evaluate their biological efficacy in inhibiting the growth and spreading of malignant tumors. The resulting approaches will provide stable and effective tools thus potentially improving the quality of life (QOL) of the cancer patients. Further, the joint research and training programme of RISE- cONCReTE will be performed in academic institutions and SME to provide a unique interdisciplinary platform for scientists with a significant contribution to EU competitiveness.

Field of science

  • /natural sciences/biological sciences/cell biology
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

H2020-MSCA-RISE-2019
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Address
Corso Umberto I, 40
80138 Napoli
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 165 600

Participants (16)

UNIVERSITAET INNSBRUCK
Austria
EU contribution
€ 110 400
Address
Innrain 52
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Germany
EU contribution
€ 110 400
Address
Regina Pacis Weg 3
53113 Bonn
Activity type
Higher or Secondary Education Establishments
FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS
Spain
EU contribution
€ 110 400
Address
Carrer Muntaner 383 3/2
08021 Barcelona
Activity type
Research Organisations
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 110 400
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA
Romania
EU contribution
€ 110 400
Address
Victor Babes Street 8
400012 Cluj-napoca
Activity type
Higher or Secondary Education Establishments
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 110 400
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 110 400
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
Spain
EU contribution
€ 110 400
Address
Avenida De Pio Xii 55
31008 Pamplona
Activity type
Research Organisations
PERCUROS BV
Netherlands
EU contribution
€ 174 800
Address
Plesmanlaan 1
2333 BZ Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
JENACELL GMBH
Germany
EU contribution
€ 128 800
Address
Goschwitzer Str. 22
07745 Jena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
XENOPAT SL
Spain
EU contribution
€ 110 400
Address
Calle Feixa Llarga S/n Edifici Bioincuoadora
08907 Hospitalet De Llobregat
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PROGREDUM GMBH
Germany
EU contribution
€ 110 400
Address
Otterberger Strasse 73
67659 Kaiserslautern
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TACIT BIO INNOVATION LIMITED
United Kingdom
EU contribution
€ 119 600
Address
Bennett Corner House, 33 Coleshill Street
B72 1SD Sutton Coldfield
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TECOBIOSCIENCES GMBH
Germany
EU contribution
€ 119 600
Address
Bussardstrasse 35
84036 Landshut
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CLINICA MEDITERRANEA SPA
Italy
EU contribution
€ 124 200
Address
Via Orazio 2
80122 Napoli
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASSOCIAZIONE HAND IN HAND
Italy
EU contribution
€ 124 200
Address
Piazza Roma 2
00074 Nemi
Activity type
Other