CORDIS - EU research results
CORDIS

DevelOpmeNt of Cancer RNA TherapEutics

Project description

ncRNAs in the fight against cancer

Non-coding RNAs (ncRNAs) regulate gene expression, and there is increasing evidence that they may be implicated in cancer development and progression. With this in mind, scientists of the EU-funded cONCReTE project will work under the hypothesis that tumour-associated ncRNAs may serve as targets for cancer therapy. cONCReTE will identify ncRNAs with a role in tumour biology. The key objective is to unveil novel functional links between ncRNAs and oncogenic pathways by monitoring their accumulation and impact in various cancer cell types. Project results will pave the way for the development of ncRNA-based therapeutics against cancer.

Objective

Non-codingRNAs (ncRNAs) represent a large class of molecules that in concert regulate the expression of genes involved in the key pathways governing cancer development and progression. They represent ideal targets for personalized cancer therapies and if appropriately designed they can provide specific, non-toxic and effective therapeutic tools. The identification of novel therapeutic ncRNAs and the design of their appropriate formulation is a key aspect for their clinical applicability. RISE- cONCReTE aims to form an international and inter-sectoral network of organizations working on a joint research programme on the development of a safe ncRNA-based drug. RISE- cONCReTE teams up experts in the fields of Molecular Oncology, Epigenetics, Signal transduction, Animal models, Therapeutic delivery and Imaging, business, and education. The participants will exchange skills, knowledge and staff members that will be exposed to synergetic and complementary research environments. RISE- cONCReTE will undertake an integrated approach to reveal novels functional links between ncRNAs and oncogenic pathways. We will: a) characterize novel classes of tumor-associated ncRNAs; b) investigate the impact of ncRNAs on key aspects of tumor cell biology; c) develop cargoes (e.g. aptamers) for delivering therapeutic ncRNA derivatives into specific cancer cell types. By using innovative in vivo imaging tools, we will monitor the accumulation of target ncRNAs in cancer cells and evaluate their biological efficacy in inhibiting the growth and spreading of malignant tumors. The resulting approaches will provide stable and effective tools thus potentially improving the quality of life (QOL) of the cancer patients. Further, the joint research and training programme of RISE- cONCReTE will be performed in academic institutions and SME to provide a unique interdisciplinary platform for scientists with a significant contribution to EU competitiveness.

Coordinator

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Net EU contribution
€ 165 600,00
Address
CORSO UMBERTO I, 40
80138 Napoli
Italy

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Region
Sud Campania Napoli
Activity type
Higher or Secondary Education Establishments
Links
Total cost
€ 165 600,00

Participants (16)