DevelOpmeNt of Cancer RNA TherapEutics

Deliverables

Documents, reports (7)

External server set up and access for all RISE-cONCReTE participants

Methods for identification of RNA binders

Identify the molecular map of RNA binders and ncRNAs and identify new target for personalized cancer therapies Characterize the role in tumor cell biology of the identified RNA binders ncRNAs

ncRNAs involved in hypoxia and, CAIX in glioma

Characterize the relationship between ncRNAs, hypoxia and, CAIX in glioma and identification of a non-coding RNA signatures. Characterize the role of ncRNAs regulating hypoxia cascade in tumor cell biology

Content for network wide events approved by Director of TOK

Appointment of Project Monitor

Identification of ncRNAs implicated in exosome-mediated tumor/stroma communication

Gender equality monitoring

Publications

Peer reviewed articles (22)

miR-216a Acts as a Negative Regulator of Breast Cancer by Modulating Stemness Properties and Tumor Microenvironment

Author(s): Giuseppina Roscigno, Assunta Cirella, Alessandra Affinito, Cristina Quintavalle, Iolanda Scognamiglio, Francesco Palma, Francesco Ingenito, Silvia Nuzzo, Francesca De Micco, Antonio Cuccuru, Renato Thomas, Gerolama Condorelli
Published in: International Journal of Molecular Sciences, 21/7, 2020, Page(s) 2313, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072313

Exploiting the Natural Properties of Extracellular Vesicles in Targeted Delivery towards Specific Cells and Tissues

Author(s): Pablo Lara, Alan B. Chan, Luis J. Cruz, Andrew F. G. Quest, Marcelo J. Kogan
Published in: Pharmaceutics, 12/11, 2020, Page(s) 1022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12111022

Urinary Dickkopf-3 and Contrast-Associated Kidney Damage

Author(s): Giuseppina Roscigno, Cristina Quintavalle, Giuseppe Biondi-Zoccai, Francesca De Micco, Giacomo Frati, Alessandra Affinito, Silvia Nuzzo, Gerolama Condorelli, Carlo Briguori
Published in: Journal of the American College of Cardiology, 77/21, 2021, Page(s) 2667-2676, ISSN 0735-1097
Publisher: Elsevier BV
DOI: 10.1016/j.jacc.2021.03.330

Zinc-Phthalocyanine-Loaded Extracellular Vesicles Increase Efficacy and Selectivity of Photodynamic Therapy in Co-Culture and Preclinical Models of Colon Cancer

Author(s): Pablo Lara, Ruben V. Huis in ‘t Veld, Carla Jorquera-Cordero, Alan B. Chan, Ferry Ossendorp, Luis J. Cruz
Published in: Pharmaceutics, 13/10, 2021, Page(s) 1547, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13101547

Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties

Author(s): Claudia Morilla, Elianis Perdomo, Ana Karla Hernández, Ramcy Regalado, Amisel Almirall, Gastón Fuentes, Yaima Campos Mora, Timo Schomann, Alan Chan, Luis J. Cruz
Published in: Molecules, 26/11, 2021, Page(s) 3272, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26113272

Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer

Author(s): Iolanda Scognamiglio, Lorenza Cocca, Ilaria Puoti, Francesco Palma, Francesco Ingenito, Cristina Quintavalle, Alessandra Affinito, Giuseppina Roscigno, Silvia Nuzzo, Rosario Vincenzo Chianese, Stefania Belli, Guglielmo Thomas, Timo Schomann, Alan Chan, Maria Patrizia Stoppelli, Gerolama Condorelli
Published in: Molecular therapy. Nucleic acids vol. 28, 2022, Page(s) 17-31, ISSN 2162-2531
Publisher: Nature Publishing Group
DOI: 10.1016/j.omtn.2022.02.013

Chemical, Antioxidant, and Antimicrobial Properties of the Peel and Male Flower By-Products of Four Varieties of Punica granatum L. Cultivated in the Marche Region for Their Use in Cosmetic Products

Author(s): Maria Rosa Gigliobianco; Manuela Cortese; Samanta Nannini; Lucrezia Di Nicolantonio; Dolores Vargas Peregrina; Giulio Lupidi; Luca Agostino Vitali; Elena Bocchietto; Piera Di Martino; Roberta Censi
Published in: Antioxidants; Volume 11; Issue 4; Pages: 768, 1, 2022, ISSN 2076-3921
Publisher: Basel, Switzerland
DOI: 10.3390/antiox11040768

Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review

Author(s): Anna Maria Grimaldi, Silvia Nuzzo, Gerolama Condorelli, Marco Salvatore, Mariarosaria Incoronato
Published in: International Journal of Molecular Sciences, 21/16, 2020, Page(s) 5834, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165834

The Incorporation of Etanercept into a Porous Tri-Layer Scaffold for Restoring and Repairing Cartilage Tissue

Author(s): Campos, Yaima; Fuentes, Gastón; Almirall, Amisel; Que, Ivo; Schomann, Timo; Chung, Chih Kit; Jorquera Cordero, Carla; Quintanilla Sierra, Luis; Rodríguez Cabello, José Carlos; Chan, Alan; Cruz, Luis
Published in: Pharmaceutics, 1, 2022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14020282

Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors

Author(s): Pasquale Russomanno; Giulia Assoni; Giulia Assoni; Jussara Amato; Vincenzo Maria D'Amore; Riccardo Scaglia; Diego Brancaccio; Martina Pedrini; Giovanna Polcaro; Valeria La Pietra; Paolo Orlando; Marianna Falzoni; Linda Cerofolini; Stefano Giuntini; Marco Fragai; Bruno Pagano; Greta Donati; E. Novellino; Cristina Quintavalle; Gerolama Condorelli; Francesco Sabbatino; Pierfausto Seneci; Daniela Aros
Published in: J. Med. Chem. 2021, 64, 16020−16045, 1, 2021, ISSN 1520-4804
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c01409

The Role of RNA and DNA Aptamers in Glioblastoma Diagnosis and Therapy: A Systematic Review of the Literature

Author(s): Silvia Nuzzo, Valentina Brancato, Alessandra Affinito, Marco Salvatore, Carlo Cavaliere, Gerolama Condorelli
Published in: Cancers, 12/8, 2020, Page(s) 2173, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12082173

Combinatorial therapeutic approaches of photodynamic therapy and immune checkpoint blockade for colon cancer treatment

Author(s): Yang Hao, Chih Kit Chung, Zili Gu, Timo Schomann, Xiaoxu Dong, Ruben V Huis In 't Veld, Marcel G M Camps, Peter Ten Dijke, Ferry A Ossendorp, Luis J Cruz
Published in: Molecular biomedicine, 2022, ISSN 2662-8651
Publisher: Singapore : Springer Singapore, [2020]-
DOI: 10.1186/s43556-022-00086-z

Identification of a novel RNA aptamer that selectively targets breast cancer exosomes

Author(s): Carla Lucia Esposito, Cristina Quintavalle, Francesco Ingenito, Deborah Rotoli, Giuseppina Roscigno, Silvia Nuzzo, Renato Thomas, Silvia Catuogno, Vittorio de Franciscis, Gerolama Condorelli
Published in: Molecular Therapy - Nucleic Acids, 2021, ISSN 2162-2531
Publisher: Nature Publishing Group
DOI: 10.1016/j.omtn.2021.01.012

miR-34c-3p targets CDK1 a synthetic lethality partner of KRAS in non-small cell lung cancer

Author(s): Francesco Palma, Alessandra Affinito, Silvia Nuzzo, Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Lola Martinez, Monica Franzese, Mario Zanfardino, Andrea Soricelli, Alfonso Fiorelli, Gerolama Condorelli, Cristina Quintavalle
Published in: Cancer Gene Therapy, 2020, ISSN 0929-1903
Publisher: Nature Publishing Group
DOI: 10.1038/s41417-020-00224-1

Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer

Author(s): Cansu de Muijnck, Yoren van Gorkom, Maurice van Duijvenvoorde, Mina Eghtesadi, Geeske Dekker-Ensink, Shadhvi S. Bhairosingh, Alessandra Affinito, Peter J. K. Kuppen, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Published in: Pharmaceuticals, 13/8, 2020, Page(s) 172, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph13080172

Nanocarriers as a Tool for the Treatment of Colorectal Cancer

Author(s): Ana Luiza C. de S. L. Oliveira, Timo Schomann, Lioe-Fee de Geus-Oei, Ellen Kapiteijn, Luis J. Cruz, Raimundo Fernandes de Araújo Junior
Published in: Pharmaceutics, 13/8, 2021, Page(s) 1321, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13081321

Comparative Proteomic Profiling of Secreted Extracellular Vesicles from Breast Fibroadenoma and Malignant Lesions: A Pilot Study

Author(s): Katia Pane, Cristina Quintavalle, Silvia Nuzzo, Francesco Ingenito, Giuseppina Roscigno, Alessandra Affinito, Iolanda Scognamiglio, Birlipta Pattanayak, Enrico Gallo, Antonella Accardo, Guglielmo Thomas, Zoran Minic, Maxim V Berezovski, Monica Franzese, Gerolama Condorelli
Published in: International journal of molecular sciences vol. 23, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073989

Thermosensitive Injectable Hydrogels for Intra-Articular Delivery of Etanercept for the Treatment of Osteoarthritis

Author(s): Jomarien García-Couce, Timo Schomann, Chih Kit Chung, Ivo Que, Carla Jorquera-Cordero, Gastón Fuentes, Amisel Almirall, Alan Chan, Luis J Cruz
Published in: Gels, Quarterly, 2022, ISSN 2310-2861
Publisher: Basel, Switzerland : MDPI AG, [2015]-
DOI: 10.3390/gels8080488

Bacterial Cellulose as Drug Delivery System for Optimizing Release of Immune Checkpoint Blocking Antibodies

Author(s): Chih Kit Chung; Uwe Beekmann; Dana Kralisch; Katja Bierau; Alan Chan; Ferry Ossendorp; Luis J. Cruz
Published in: Pharmaceutics; Volume 14; Issue 7; Pages: 1351, 1, 2022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14071351

Cell-Based Tracers as Trojan Horses for Image-Guided Surgery

Author(s): Vincent Q. Sier, Margreet R. de Vries, Joost R. van der Vorst, Alexander L. Vahrmeijer, Cornelis van Kooten, Luis J. Cruz, Lioe-Fee de Geus-Oei, Valerie Ferreira, Cornelis F. M. Sier, Frauke Alves, Munitta Muthana
Published in: International Journal of Molecular Sciences, 22/2, 2021, Page(s) 755, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020755

Modulating the Crosstalk between the Tumor and the Microenvironment Using SiRNA: A Flexible Strategy for Breast Cancer Treatment

Author(s): Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Rosario Vincenzo Chianese, Francesco Palma, Alan Chan, Gerolama Condorelli
Published in: Cancers, 12/12, 2020, Page(s) 3744, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123744

Structure‐ and Interaction‐Based Design of Anti‐SARS‐CoV‐2 Aptamers

Author(s): Mironov V, Shchugoreva IA, Artyushenko PV, Morozov D, Borbone N, Oliviero G, Zamay TN, Moryachkov RV, Kolovskaya OS, Lukyanenko KA, Song Y, Merkuleva IA, Zabluda VN, Peters G, Koroleva LS, Veprintsev DV, Glazyrin YE, Volosnikova EA, Belenkaya SV, Esina TI, Isaeva AA, Nesmeyanova VS, Shanshin DV, Berlina AN, Komova NS, Svetlichnyi VA, Silnikov VN, Shcherbakov DN, Zamay GS, Zamay SS, Smolyarova T, T
Published in: Chemistry, vol 28, 2022, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202104481