Deliverables Documents, reports (11) Developing a morphology-based RNAi-screening assay for the detection of EMT or MET External server set up and access for all RISE-cONCReTE participants Characterizing the roles of ncRNAs involved in EMT Methods for the identification of non-coding RNA modulated by histone modification colon and breast cancer cell lines are used Methods for identification of RNA binders Identify the molecular map of RNA binders and ncRNAs and identify new target for personalized cancer therapies Characterize the role in tumor cell biology of the identified RNA binders ncRNAs ncRNAs involved in hypoxia and, CAIX in glioma Characterize the relationship between ncRNAs, hypoxia and, CAIX in glioma and identification of a non-coding RNA signatures. Characterize the role of ncRNAs regulating hypoxia cascade in tumor cell biology Content for network wide events approved by Director of TOK Appointment of Project Monitor Identification of ncRNAs implicated in exosome-mediated tumor/stroma communication Identification of non coding RNA loci modulated by DNA methylation that could represent novel therapeutical target two sources of human malignancies are used cancer cell lines and primary tumors Gender equality monitoring Publications Peer reviewed articles (25) miR-216a Acts as a Negative Regulator of Breast Cancer by Modulating Stemness Properties and Tumor Microenvironment Author(s): Giuseppina Roscigno, Assunta Cirella, Alessandra Affinito, Cristina Quintavalle, Iolanda Scognamiglio, Francesco Palma, Francesco Ingenito, Silvia Nuzzo, Francesca De Micco, Antonio Cuccuru, Renato Thomas, Gerolama Condorelli Published in: International Journal of Molecular Sciences, 21/7, 2020, Page(s) 2313, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms21072313 Practical tips and new trends in electrochemical biosensing of cancer-related extracellular vesicles Author(s): Patrick Severin Sfragano, Serena Pillozzi, Gerolama Condorelli, Ilaria Palchetti Published in: Analytical and bioanalytical chemistry., 2023, Page(s) 1-20, ISSN 1618-2650 Publisher: Springer DOI: 10.1007/s00216-023-04530-z Exploiting the Natural Properties of Extracellular Vesicles in Targeted Delivery towards Specific Cells and Tissues Author(s): Pablo Lara, Alan B. Chan, Luis J. Cruz, Andrew F. G. Quest, Marcelo J. Kogan Published in: Pharmaceutics, 12/11, 2020, Page(s) 1022, ISSN 1999-4923 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/pharmaceutics12111022 Urinary Dickkopf-3 and Contrast-Associated Kidney Damage Author(s): Giuseppina Roscigno, Cristina Quintavalle, Giuseppe Biondi-Zoccai, Francesca De Micco, Giacomo Frati, Alessandra Affinito, Silvia Nuzzo, Gerolama Condorelli, Carlo Briguori Published in: Journal of the American College of Cardiology, 77/21, 2021, Page(s) 2667-2676, ISSN 0735-1097 Publisher: Elsevier BV DOI: 10.1016/j.jacc.2021.03.330 Zinc-Phthalocyanine-Loaded Extracellular Vesicles Increase Efficacy and Selectivity of Photodynamic Therapy in Co-Culture and Preclinical Models of Colon Cancer Author(s): Pablo Lara, Ruben V. Huis in ‘t Veld, Carla Jorquera-Cordero, Alan B. Chan, Ferry Ossendorp, Luis J. Cruz Published in: Pharmaceutics, 13/10, 2021, Page(s) 1547, ISSN 1999-4923 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/pharmaceutics13101547 Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties Author(s): Claudia Morilla, Elianis Perdomo, Ana Karla Hernández, Ramcy Regalado, Amisel Almirall, Gastón Fuentes, Yaima Campos Mora, Timo Schomann, Alan Chan, Luis J. Cruz Published in: Molecules, 26/11, 2021, Page(s) 3272, ISSN 1420-3049 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules26113272 Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer Author(s): Iolanda Scognamiglio, Lorenza Cocca, Ilaria Puoti, Francesco Palma, Francesco Ingenito, Cristina Quintavalle, Alessandra Affinito, Giuseppina Roscigno, Silvia Nuzzo, Rosario Vincenzo Chianese, Stefania Belli, Guglielmo Thomas, Timo Schomann, Alan Chan, Maria Patrizia Stoppelli, Gerolama Condorelli Published in: Molecular therapy. Nucleic acids vol. 28, 2022, Page(s) 17-31, ISSN 2162-2531 Publisher: Nature Publishing Group DOI: 10.1016/j.omtn.2022.02.013 Chemical, Antioxidant, and Antimicrobial Properties of the Peel and Male Flower By-Products of Four Varieties of Punica granatum L. Cultivated in the Marche Region for Their Use in Cosmetic Products Author(s): Maria Rosa Gigliobianco; Manuela Cortese; Samanta Nannini; Lucrezia Di Nicolantonio; Dolores Vargas Peregrina; Giulio Lupidi; Luca Agostino Vitali; Elena Bocchietto; Piera Di Martino; Roberta Censi Published in: Antioxidants; Volume 11; Issue 4; Pages: 768, 1, 2022, ISSN 2076-3921 Publisher: Basel, Switzerland DOI: 10.3390/antiox11040768 Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review Author(s): Anna Maria Grimaldi, Silvia Nuzzo, Gerolama Condorelli, Marco Salvatore, Mariarosaria Incoronato Published in: International Journal of Molecular Sciences, 21/16, 2020, Page(s) 5834, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms21165834 The Incorporation of Etanercept into a Porous Tri-Layer Scaffold for Restoring and Repairing Cartilage Tissue Author(s): Campos, Yaima; Fuentes, Gastón; Almirall, Amisel; Que, Ivo; Schomann, Timo; Chung, Chih Kit; Jorquera Cordero, Carla; Quintanilla Sierra, Luis; Rodríguez Cabello, José Carlos; Chan, Alan; Cruz, Luis Published in: Pharmaceutics, 1, 2022, ISSN 1999-4923 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/pharmaceutics14020282 Selection of RNA aptamers targeting hypoxia in cancer Author(s): Nuzzo S, Iaboni M, Ibba ML, Rienzo A, Musumeci D, Franzese M, Roscigno G, Affinito A, Petrillo G, Quintavalle C, Ciccone G, Esposito CL, Catuogno S Published in: Frontiers in molecular biosciences, 2296889X, 2022, ISSN 2296-889X Publisher: Lausanne : Frontiers Media S.A DOI: 10.3389/fmolb.2022.956935 Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors Author(s): Pasquale Russomanno; Giulia Assoni; Giulia Assoni; Jussara Amato; Vincenzo Maria D'Amore; Riccardo Scaglia; Diego Brancaccio; Martina Pedrini; Giovanna Polcaro; Valeria La Pietra; Paolo Orlando; Marianna Falzoni; Linda Cerofolini; Stefano Giuntini; Marco Fragai; Bruno Pagano; Greta Donati; E. Novellino; Cristina Quintavalle; Gerolama Condorelli; Francesco Sabbatino; Pierfausto Seneci; Daniela Aros Published in: J. Med. Chem. 2021, 64, 16020−16045, 1, 2021, ISSN 1520-4804 Publisher: American Chemical Society DOI: 10.1021/acs.jmedchem.1c01409 The Role of RNA and DNA Aptamers in Glioblastoma Diagnosis and Therapy: A Systematic Review of the Literature Author(s): Silvia Nuzzo, Valentina Brancato, Alessandra Affinito, Marco Salvatore, Carlo Cavaliere, Gerolama Condorelli Published in: Cancers, 12/8, 2020, Page(s) 2173, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers12082173 Combinatorial therapeutic approaches of photodynamic therapy and immune checkpoint blockade for colon cancer treatment Author(s): Yang Hao, Chih Kit Chung, Zili Gu, Timo Schomann, Xiaoxu Dong, Ruben V Huis In 't Veld, Marcel G M Camps, Peter Ten Dijke, Ferry A Ossendorp, Luis J Cruz Published in: Molecular biomedicine, 2022, ISSN 2662-8651 Publisher: Singapore : Springer Singapore, [2020]- DOI: 10.1186/s43556-022-00086-z Identification of a novel RNA aptamer that selectively targets breast cancer exosomes Author(s): Carla Lucia Esposito, Cristina Quintavalle, Francesco Ingenito, Deborah Rotoli, Giuseppina Roscigno, Silvia Nuzzo, Renato Thomas, Silvia Catuogno, Vittorio de Franciscis, Gerolama Condorelli Published in: Molecular Therapy - Nucleic Acids, 2021, ISSN 2162-2531 Publisher: Nature Publishing Group DOI: 10.1016/j.omtn.2021.01.012 miR-34c-3p targets CDK1 a synthetic lethality partner of KRAS in non-small cell lung cancer Author(s): Francesco Palma, Alessandra Affinito, Silvia Nuzzo, Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Lola Martinez, Monica Franzese, Mario Zanfardino, Andrea Soricelli, Alfonso Fiorelli, Gerolama Condorelli, Cristina Quintavalle Published in: Cancer Gene Therapy, 2020, ISSN 0929-1903 Publisher: Nature Publishing Group DOI: 10.1038/s41417-020-00224-1 Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer Author(s): Cansu de Muijnck, Yoren van Gorkom, Maurice van Duijvenvoorde, Mina Eghtesadi, Geeske Dekker-Ensink, Shadhvi S. Bhairosingh, Alessandra Affinito, Peter J. K. Kuppen, Alexander L. Vahrmeijer, Cornelis F. M. Sier Published in: Pharmaceuticals, 13/8, 2020, Page(s) 172, ISSN 1424-8247 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ph13080172 Nanocarriers as a Tool for the Treatment of Colorectal Cancer Author(s): Ana Luiza C. de S. L. Oliveira, Timo Schomann, Lioe-Fee de Geus-Oei, Ellen Kapiteijn, Luis J. Cruz, Raimundo Fernandes de Araújo Junior Published in: Pharmaceutics, 13/8, 2021, Page(s) 1321, ISSN 1999-4923 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/pharmaceutics13081321 Smart Polymeric Micelles for Anticancer Hydrophobic Drugs Author(s): Guzmán Rodríguez A, Sablón Carrazana M, Rodríguez Tanty C, Malessy MJA, Fuentes G, Cruz LJ. Published in: Cancers (Basel), 2022, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers15010004 Comparative Proteomic Profiling of Secreted Extracellular Vesicles from Breast Fibroadenoma and Malignant Lesions: A Pilot Study Author(s): Katia Pane, Cristina Quintavalle, Silvia Nuzzo, Francesco Ingenito, Giuseppina Roscigno, Alessandra Affinito, Iolanda Scognamiglio, Birlipta Pattanayak, Enrico Gallo, Antonella Accardo, Guglielmo Thomas, Zoran Minic, Maxim V Berezovski, Monica Franzese, Gerolama Condorelli Published in: International journal of molecular sciences vol. 23, 2022, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms23073989 Thermosensitive Injectable Hydrogels for Intra-Articular Delivery of Etanercept for the Treatment of Osteoarthritis Author(s): Jomarien García-Couce, Timo Schomann, Chih Kit Chung, Ivo Que, Carla Jorquera-Cordero, Gastón Fuentes, Amisel Almirall, Alan Chan, Luis J Cruz Published in: Gels, Quarterly, 2022, ISSN 2310-2861 Publisher: Basel, Switzerland : MDPI AG, [2015]- DOI: 10.3390/gels8080488 Bacterial Cellulose as Drug Delivery System for Optimizing Release of Immune Checkpoint Blocking Antibodies Author(s): Chih Kit Chung; Uwe Beekmann; Dana Kralisch; Katja Bierau; Alan Chan; Ferry Ossendorp; Luis J. Cruz Published in: Pharmaceutics; Volume 14; Issue 7; Pages: 1351, 1, 2022, ISSN 1999-4923 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/pharmaceutics14071351 Cell-Based Tracers as Trojan Horses for Image-Guided Surgery Author(s): Vincent Q. Sier, Margreet R. de Vries, Joost R. van der Vorst, Alexander L. Vahrmeijer, Cornelis van Kooten, Luis J. Cruz, Lioe-Fee de Geus-Oei, Valerie Ferreira, Cornelis F. M. Sier, Frauke Alves, Munitta Muthana Published in: International Journal of Molecular Sciences, 22/2, 2021, Page(s) 755, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms22020755 Modulating the Crosstalk between the Tumor and the Microenvironment Using SiRNA: A Flexible Strategy for Breast Cancer Treatment Author(s): Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Rosario Vincenzo Chianese, Francesco Palma, Alan Chan, Gerolama Condorelli Published in: Cancers, 12/12, 2020, Page(s) 3744, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers12123744 Structure‐ and Interaction‐Based Design of Anti‐SARS‐CoV‐2 Aptamers Author(s): Mironov V, Shchugoreva IA, Artyushenko PV, Morozov D, Borbone N, Oliviero G, Zamay TN, Moryachkov RV, Kolovskaya OS, Lukyanenko KA, Song Y, Merkuleva IA, Zabluda VN, Peters G, Koroleva LS, Veprintsev DV, Glazyrin YE, Volosnikova EA, Belenkaya SV, Esina TI, Isaeva AA, Nesmeyanova VS, Shanshin DV, Berlina AN, Komova NS, Svetlichnyi VA, Silnikov VN, Shcherbakov DN, Zamay GS, Zamay SS, Smolyarova T, T Published in: Chemistry, vol 28, 2022, ISSN 0947-6539 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/chem.202104481 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
