Project description
Developing next-gen tools for early lifecourse exposome research
Defined as the measure of all of an individual’s exposures in a lifetime and how these affect their health, the exposome can help discover the key exposures responsible for chronic diseases. To aid this discovery, the EU-funded ATHLETE project aims to develop a toolbox of advanced, next-generation exposome tools and a prospective exposome cohort. This will be used to systematically quantify the effects of a wide range of environmental risk factors on mental, cardiometabolic and respiratory health outcomes and associated biological pathways during the first 20 years of life. The project’s achievements will aid in the implementation of acceptable and feasible exposome interventions; moreover, they could inform policy recommendations and prevention strategies.
Objective
ATHLETE aims to develop a toolbox of advanced, next-generation, exposome tools and a prospective exposome cohort, which will be used to systematically quantify the effects of a wide range of community-level and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways during the first 2 decades of life, to implement acceptable and feasible exposome interventions, and to translate the resulting evidence to policy recommendations and prevention strategies.
ATHLETE will establish a prospective exposome cohort, including FAIR data infrastructure, building on Europe’s most comprehensive already existing exposome data (18 cohorts in 12 European countries). ATHLETE will systematically characterise the effects of the exposome on early organ development, health trajectories, and biological pathways (metagenomic, metabolomic, epigenetic, ageing, and stress pathways), longitudinally from early pregnancy through adolescence. Innovative tool development will focus on: 1) complete and accurate measurement of multiple environmental risk factors (external/urban, chemical, physical, behavioural, social) through new targeted and untargeted exposure science approaches, 2) development of advanced statistical and toxicological strategies to analyse complex multi-dimensional exposome data, 3) development of interventions to reduce personal exposures, co-produced with the community, and 4) estimation of the societal impact of the exposome by calculating costs and child health impacts.
ATHLETE’s strong focus on the vulnerable early stages of the life course, widespread general population exposures and common non-communicable diseases, its use of a large body of existing exposome data and expertise, its strong emphasis on knowledge translation, its development of an open online toolbox and its close collaboration in the European Human Exposome Network ensure that the objectives are achievable and highly relevant for future research and policy.
ATHLETE is part of the European Human Exposome Network comprised of 9 projects selected from this same call.
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RIA - Research and Innovation actionCoordinator
08036 Barcelona
Spain
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Participants (27)
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
46010 Valencia
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75654 Paris
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0456 Oslo
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3015 GD Rotterdam
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SW7 2AZ LONDON
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BD9 6RJ Bradford
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9713 GZ Groningen
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1210 Saint-Josse-Ten-Noode
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3721 MA Bilthoven
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74100 Rethimno
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LT-44248 Kaunas
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3500 Hasselt
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10124 Torino
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08950 Esplugues De Llobregat
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
08950 Esplugues De Llobregat
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75794 Paris
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
91192 Gif Sur Yvette
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08907 HOSPITALET DE LLOBREGAT
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
NG1 4FQ Nottingham
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90089 5013 Los Angeles Ca
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UB8 3PH Uxbridge
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NE1 7RU Newcastle Upon Tyne
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94700 Maisons Alfort
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1165 Kobenhavn
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601 77 Brno
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4050 290 Porto
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
L69 7ZX Liverpool
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