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Controlled Organoids transplantation as enabler for regenerative medicine translation

Deliverables

Project webpage

Description of the ORGANTRANS webpage that will be prepared in the first months of the project

Dissemination and communication strategy

The definition of the dissemination and communication strategy and tools to be used during the life of the project All possible dissemination routes for the obtained results will be identified and used during the whole course of the project

Protocol for the large-scale production of liver organoids

Publication of an optimised SOP for largescale expansion of organoids cultured in spinning bioreactors

Six established and fully characterized individual hepatic organoid lines

Characterisation of the organoid lines with respect to stem cell characteristics and differentiation potential will be published

Upscaling from research to medical Sphericalplate 5D

Upscaling takes place by changing the Sphericalplate 5D research plate to the Sphericalplate 5D medical platform and assures the biological integrity of the cultivated organoids

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Publications

Large‐Scale Production of LGR5‐Positive Bipotential Human Liver Stem Cells

Author(s): Kerstin Schneeberger, Natalia Sánchez‐Romero, Shicheng Ye, Frank G. Steenbeek, Loes A. Oosterhoff, Iris Pla Palacin, Chen Chen, Monique E. Wolferen, Gilles Tienderen, Ruby Lieshout, Haaike Colemonts‐Vroninks, Imre Schene, Ruurdtje Hoekstra, Monique M.A. Verstegen, Luc J.W. Laan, Louis C. Penning, Sabine A. Fuchs, Hans Clevers, Joery De Kock, Pedro M. Baptista, Bart Spee
Published in: Hepatology, 72/1, 2020, Page(s) 257-270, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.31037

Bicyclic RGD peptides enhance nerve growth in synthetic PEG-based Anisogels

Author(s): Sitara Vedaraman, Dominik Bernhagen, Tamas Haraszti, Christopher Licht, Arturo Castro Nava, Abdolrahman Omidinia Anarkoli, Peter Timmerman, Laura De Laporte
Published in: Biomaterials Science, 9/12, 2021, Page(s) 4329-4342, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0bm02051f

Digitally Fabricated and Naturally Augmented In Vitro Tissues

Author(s): Daniela F. Duarte Campos, Laura De Laporte
Published in: Advanced Healthcare Materials, 10/2, 2021, Page(s) 2001253, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202001253

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

Author(s): Ary Marsee, Floris J.M. Roos, Monique M.A. Verstegen, Helmuth Gehart, Eelco de Koning, Frédéric Lemaigre, Stuart J. Forbes, Weng Chuan Peng, Meritxell Huch, Takanori Takebe, Ludovic Vallier, Hans Clevers, Luc J.W. van der Laan, Bart Spee, Ary Marsee, Floris Roos, Monique Verstegen, Hans Clevers, Ludovic Vallier, Takanori Takebe, Meritxell Huch, Weng Chuan Peng, Stuart Forbes, Frédéric Lemaigre
Published in: Cell Stem Cell, 28/5, 2021, Page(s) 816-832, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2021.04.005