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Controlled Organoids transplantation as enabler for regenerative medicine translation

Leistungen

Project webpage

Description of the ORGANTRANS webpage that will be prepared in the first months of the project.

Dissemination and communication strategy

The definition of the dissemination and communication strategy and tools to be used during the life of the project. All possible dissemination routes for the obtained results will be identified and used during the whole course of the project.

Protocol for the large-scale production of liver organoids

Publication of an optimised SOP for large-scale expansion of organoids cultured in spinning bioreactors.

Six established and fully characterized individual hepatic organoid lines

Characterisation of the organoid lines with respect to stem cell characteristics and differentiation potential will be published.

Upscaling from research to medical Sphericalplate 5D

Upscaling takes place by changing the Sphericalplate 5D research plate to the Sphericalplate 5D medical platform and assures the biological integrity of the cultivated organoids

Veröffentlichungen

Large‐Scale Production of LGR5‐Positive Bipotential Human Liver Stem Cells

Autoren: Kerstin Schneeberger, Natalia Sánchez‐Romero, Shicheng Ye, Frank G. Steenbeek, Loes A. Oosterhoff, Iris Pla Palacin, Chen Chen, Monique E. Wolferen, Gilles Tienderen, Ruby Lieshout, Haaike Colemonts‐Vroninks, Imre Schene, Ruurdtje Hoekstra, Monique M.A. Verstegen, Luc J.W. Laan, Louis C. Penning, Sabine A. Fuchs, Hans Clevers, Joery De Kock, Pedro M. Baptista, Bart Spee
Veröffentlicht in: Hepatology, 72/1, 2020, Page(s) 257-270, ISSN 0270-9139
Herausgeber: John Wiley & Sons Inc.
DOI: 10.1002/hep.31037

Bicyclic RGD peptides enhance nerve growth in synthetic PEG-based Anisogels

Autoren: Sitara Vedaraman, Dominik Bernhagen, Tamas Haraszti, Christopher Licht, Arturo Castro Nava, Abdolrahman Omidinia Anarkoli, Peter Timmerman, Laura De Laporte
Veröffentlicht in: Biomaterials Science, 9/12, 2021, Page(s) 4329-4342, ISSN 2047-4830
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/d0bm02051f

Digitally Fabricated and Naturally Augmented In Vitro Tissues

Autoren: Daniela F. Duarte Campos, Laura De Laporte
Veröffentlicht in: Advanced Healthcare Materials, 10/2, 2021, Page(s) 2001253, ISSN 2192-2640
Herausgeber: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202001253

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

Autoren: Ary Marsee, Floris J.M. Roos, Monique M.A. Verstegen, Helmuth Gehart, Eelco de Koning, Frédéric Lemaigre, Stuart J. Forbes, Weng Chuan Peng, Meritxell Huch, Takanori Takebe, Ludovic Vallier, Hans Clevers, Luc J.W. van der Laan, Bart Spee, Ary Marsee, Floris Roos, Monique Verstegen, Hans Clevers, Ludovic Vallier, Takanori Takebe, Meritxell Huch, Weng Chuan Peng, Stuart Forbes, Frédéric Lemaigre
Veröffentlicht in: Cell Stem Cell, 28/5, 2021, Page(s) 816-832, ISSN 1934-5909
Herausgeber: Cell Press
DOI: 10.1016/j.stem.2021.04.005