EXposome Powered tools for healthy living in urbAN SEttings

Deliverables

A first set of working groups will be made and Term of Reference for the WGs will be specified including the selection of work group leaders, co-leads and members.

Handover document to next coordinating team

Document summarising network activities and ongoing activities to facilitate a smooth transition to the next team. This document will include concise reports from working groups.

Ethics by Design recommendations reports (months 12, 24, 36, 48 and 60)

Ethics by Design recommendations reports (months 12, 24, 36, 48 and 60), incorporating the

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Publications

Epigenetic mechanisms of lung carcinogenesis involve differentially methylated CpG sites beyond those associated with smoking

Author(s): Petrovic D, Bodinier B, Dagnino S, Whitaker M, Karimi M, Campanella G, Haugdahl Nost T, Polidoro S, Palli D, Krogh V, Tumino R, Sacerdote C, Panico S, Lund E, Dugue PA, Giles GG, Severi G, Southey M, Vineis P, Stringhini S, Bochud M, Sandanger TM, Vermeulen RCH, Guida F, Chadeau-Hyam M.
Published in: European Journal of Epidemiology, 2022, ISSN 0393-2990
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10654-022-00877-2

Twin peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England

Author(s): Elliott P, Eales O, Steyn N, Tang D, Bodinier B, Wang H, Elliott J, Whitaker M, Atchison C, Diggle PJ, Page AJ, Trotter AJ, Ashby D, Barclay W, Taylor G, Ward H, Darzi A, Cooke GS, Donnelly CA, Chadeau-Hyam M
Published in: Science, 2022, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abq4411

Effects of pesticide exposure on oxidative stress and DNA methylation urinary biomarkers in Czech adults and children from the CELSPAC-SPECIMEn cohort

Author(s): Tomas Janos, Ilse Ottenbros,Lucie Blahov, Petr Senka, Libor Sulca, Nina Palesova, Jessica Sheardova, Jelle Vlaanderen, Pavel Cupr
Published in: Environmental Research, Volume 222 115368, 2023, ISSN 1096-0953
Publisher: Elsevier
DOI: 10.1016/j.envres.2023.115368

Agent-based modeling of urban exposome interventions: prospects, model architectures, and methodological challenges

Author(s): Tabea Sonnenschein, Simon Scheider, G Ardine de Wit, Cathryn C Tonne, Roel Vermeulen
Published in: Exposome, Volume 2 / 2022, 2022, ISSN 2635-2265
Publisher: Oxford University Press
DOI: 10.1093/exposome/osac009

A Knowledge Transfer Approach to Map Long-Term Concentrations of Hyperlocal Air Pollution from Short-Term Mobile Measurements

Author(s): Yuan, Z., Kerckhoffs, J., Hoek, G., & Vermeulen, R.
Published in: Environmental Science & Technology, Volume 56 / 2022, 2022, Page(s) 13820 - 13828, ISSN 1520-5851
Publisher: ACS Publications
DOI: 10.1021/acs.est.2c05036

Mixed-Effects Modeling Framework for Amsterdam and Copenhagen for Outdoor NO2 Concentrations Using Measurements Sampled with Google Street View Cars

Author(s): Jules Kerckhoffs*, Jibran Khan, Gerard Hoek, Zhendong Yuan, Thomas Ellermann, Ole Hertel, Matthias Ketzel, Steen Solvang Jensen, Kees Meliefste, and Roel Vermeulen
Published in: Environmental Science and Technology, 2022, 2022, ISSN 0013-936X
Publisher: American Chemical Society
DOI: 10.1021/acs.est.1c05806

Predictive symptoms for COVID-19 in the community: REACT-1 study of over 1 million people

Author(s): Joshua Elliott, Matthew Whitaker, Barbara Bodinier, Oliver Eales, Steven Riley, Helen Ward, Graham Cooke, Ara Darzi, Marc Chadeau-Hyam, Paul Elliott
Published in: PLOS Medicine, 18/9, 2021, Page(s) e1003777, ISSN 1549-1676
Publisher: PLOS
DOI: 10.1371/journal.pmed.1003777

Allergies to food and airborne allergens in children and adolescents: role of epigenetics in a changing environment.

Author(s): Melén, E., Koppelman, G. H., Vicedo-Cabrera, A. M., Andersen, Z. J., & Bunyavanich, S.
Published in: The Lancet Child & Adolescent Health, Volume 6 / 2022, 2022, Page(s) 810 - 819, ISSN 2352-4642
Publisher: Elsevier
DOI: 10.1016/s2352-4642(22)00215-2

Machine learning approaches to characterize the obesogenic urban exposome

Author(s): Haykanush Ohanyan, Lützen Portengen, Anke Huss, Eugenio Traini, Joline W.J. Beulens, Gerard Hoek, Jeroen Lakerveld, Roel Vermeulen,
Published in: Environment International, Volume 158 / 2022, 2021, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.107015

Environmental risk factors of type 2 diabetes—an exposome approach

Author(s): Joline W. J. Beulens, Maria G. M. Pinho, Taymara C. Abreu, Nicole R. den Braver, Thao M. Lam, Anke Huss, Jelle Vlaanderen, Tabea Sonnenschein, Noreen Z. Siddiqui, Zhendong Yuan, Jules Kerckhoffs, Alexandra Zhernakova, Milla F. Brandao Gois & Roel C. H. Vermeulen
Published in: Diabetologia, Volume 65 / 2022, 2021, Page(s) 263 - 274, ISSN 1432-0428
Publisher: Journal of the European Association for the Study of Diabetes (EASD).
DOI: 10.1007/s00125-021-05618-w

Dynamics of a national Omicron SARS-CoV-2 epidemic during January 2022 in England

Author(s): Elliott P, Eales O, Bodinier B, Tang D, Wang H, Jonnerby J, Haw D, Elliott J, Whitaker M, Walters CE, Atchison C, Diggle PJ, Page AJ, Trotter AJ, Ashby D, Barclay W, Taylor G, Ward H, Darzi A, Cooke GS, Chadeau-Hyam M, Donnelly CA
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32121-6

Developing the building blocks to elucidate the impact of the urban exposome on cardiometabolic-pulmonary disease

Author(s): Jelle Vlaanderen, Kees de Hoogh, Gerard Hoek, Annette Peters, Nicole Probst-Hensch, Augustin Scalbert, Erik Melén, Cathryn Tonne, G. Ardine de Wit, Marc Chadeau-Hyam, Klea Katsouyanni, Tõnu Esko, Karin R. Jongsma, Roel Vermeulen
Published in: Environmental Epidemiology, 5/4, 2021, Page(s) e162, ISSN 2474-7882
Publisher: Wolters Kluwer Health
DOI: 10.1097/ee9.0000000000000162

Merging the exposome into an integrated framework for “omics” sciences.

Author(s): Elliott J. Price, Chiara M. Vitale, Gary W. Miller, Arthur David, Robert Barouki, Karine Audouze, Douglas I. Walker, Jean-Philippe Antignac, Xavier Coumoul, Vincent Bessonneau, Jana Klánová,
Published in: iScience, Volume 25 / 2022, 2022, ISSN 2589-0042
Publisher: 2589-0042
DOI: 10.1016/j.isci.2022.103976

The human microbial exposome: expanding the Exposome-Explorer database with gut microbial metabolites.

Author(s): Vanessa Neveu, Geneviève Nicolas, Adam Amara, Reza M. Salek, Augustin Scalbert
Published in: Scientific reports, Volume 13 / 2023, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-26366-w

Ultra-processed food consumption patterns among older adults in the Netherlands and the role of the food environment

Author(s): Pinho MGM, Lakerveld J, Harbers MC, Sluijs I, Vermeulen R, Huss A, Boer JMA, Verschuren WMM, Brug J, Beulens JWJ, Mackenbach JD
Published in: European Journal of Nutrition, Volume 60 / 2021, 2020, Page(s) 2567 - 2580, ISSN 1436-6215
Publisher: Springer Nature
DOI: 10.1007/s00394-020-02436-5

Hallmarks of environmental insults

Author(s): Annette Peters, Tim S. Nawrot, Andrea A. Baccarelli
Published in: Cell, 184/6, 2021, Page(s) 1455-1468, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2021.01.043

Narrative review of citizen science in environmental epidemiology: Setting the stage for co-created research projects in environmental epidemiology

Author(s): Frederique Froeling, Florence Gignac, Gerard Hoek, Roel Vermeulen, Mark Nieuwenhuijsen, Antonella Ficorilli, Bruna De Marchi, Annibale Biggeri, David Kocman, Johanna Amalia Robinson, Regina Grazuleviciene, Sandra Andrusaityte, Valeria Righi, Xavier Basagaña
Published in: Environment International, 152, 2021, Page(s) 106470, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106470

Survey-derived activity space-based exposures to fast food outlets and their cross-sectional associations with use of fast food outlets, diet quality and BMI

Author(s): Mackenbach JD, Widener MJ, van der Gaag E, Pinho MGM
Published in: Health & Place, Volume 79 / 2023, 2023, ISSN 1353-8292
Publisher: Elsevier BV
DOI: 10.1016/j.healthplace.2023.102966

Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England

Author(s): Whitaker M, Elliott J, Bodinier B, Barclay W, Ward H, Cooke G, Donnelly CA, Chadeau-Hyam M, Elliott P.
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34244-2

Genotoxic effects of transboundary pollutants in Pinus mugo in the high mountain habitats

Author(s): Eva Klemmová Gregušková, Daniel Mihálik, Ján Kraic, Michaela Mrkvová, Jozef Sokol, Petr Gregor, Aneta Rafajová, Pavel Čupr,
Published in: Ecological Indicators, Volume 140 / 2022, 2022, ISSN 1872-7034
Publisher: Elsevier
DOI: 10.1016/j.ecolind.2022.109009

Dynamics of competing SARS-CoV-2 variants during the Omicron epidemic in England.

Author(s): Eales O, de Oliveira Martins L, Page AJ, Wang H, Bodinier B, Tang D, Haw D, Jonnerby J, Atchison C, Ashby D, Barclay W, Taylor G, Cooke G, Ward H, Darzi A, Riley S, Elliott P, Donnelly CA, Chadeau-Hyam M.
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32096-4

Hyperlocal variation of nitrogen dioxide, black carbon, and ultrafine particles measured with Google Street View cars in Amsterdam and Copenhagen

Author(s): Jules Kerckhoffs, Jibran Khan, Gerard Hoek, Zhendong Yuan, Ole Hertel, Matthias Ketzel, Steen Solvang Jensen, Fares Al Hasan, Kees Meliefste, Roel Vermeulen,
Published in: Environment International, Volume 170 / 2022, 2022, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2022.107575

Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study

Author(s): Gang Wang, Jenny Hallberg, Dimitrios Charalampopoulos, Maribel Casas Sanahuja, Robab Breyer-Kohansal, Arnulf Langhammer, Raquel Granell, Judith M. Vonk, Annemiek Mian, Núria Olvera, Lisbeth Mølgaard Laustsen, Eva Rönmark, Alicia Abellan, Alvar Agusti, Syed Hasan Arshad, Anna Bergström, H. Marike Boezen, Marie-Kathrin Breyer, Otto Burghuber, Anneli Clea Bolund, Adnan Custovic, Graham Devereux,
Published in: ERJ open research, 7: 00457-2021, 2021, ISSN 2312-0541
Publisher: European Respiratory Society
DOI: 10.1183/23120541.00457-2021

Breakthrough SARS-CoV-2 infections in double and triple vaccinated adults and single dose vaccine effectiveness among children in Autumn 2021 in England: REACT-1 study

Author(s): Chadeau-Hyam M, Eales O, Bodinier B, Wang H, Haw D, Whitaker M, Elliott J, Walters CE, Jonnerby J, Atchison C, Diggle PJ, Page AJ, Ashby D, Barclay W, Taylor G, Cooke G, Ward H, Darzi A, Donnelly CA, Elliott P
Published in: EClinicalMedicine, 2022, ISSN 2589-5370
Publisher: Elsevier
DOI: 10.1016/j.eclinm.2022.101419

Persistent COVID-19 symptoms in a community study of 606,434 people in England

Author(s): Whitaker M, Elliott J, Chadeau-Hyam M, Riley S, Darzi A, Cooke G, Ward H, Elliott P
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-29521-z

Education, biological ageing, all-cause and cause-specific mortality and morbidity: UK biobank cohort study

Author(s): Marc Chadeau-Hyam, Barbara Bodinier, Roel Vermeulen, Maryam Karimi, Verena Zuber, Raphaële Castagné, Joshua Elliott, David Muller, Dusan Petrovic, Matthew Whitaker, Silvia Stringhini, Ioanna Tzoulaki, Mika Kivimäki, Paolo Vineis, Paul Elliott, Michelle Kelly-Irving, Cyrille Delpierre
Published in: EClinicalMedicine, 29-30, 2020, Page(s) 100658, ISSN 2589-5370
Publisher: Elsevier
DOI: 10.1016/j.eclinm.2020.100658

Rapid increase in Omicron infections in England during December 2021: REACT-1 study.

Author(s): Elliott P, Bodinier B, Eales O, Wang H, Haw D, Elliott J, Whitaker M, Jonnerby J, Tang D, Walters CE, Atchison C, Diggle PJ, Page AJ, Trotter AJ, Ashby D, Barclay W, Taylor G, Ward H, Darzi A, Cooke GS, Chadeau-Hyam M, Donnelly CA.
Published in: Science, 2022, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abn8347

Analytical strategies for chemical exposomics: exploring limits and feasibility

Author(s): Chiara Maria Vitale, Elliott J Price, Gary W Miller, Arthur David, Jean-Philippe Antignac, Robert Barouki, Jana Klánová,
Published in: Exposome, Volume 1 / 2021, 2021, ISSN 2635-2265
Publisher: Oxford University Press
DOI: 10.1093/exposome/osab003

Residential proximity to livestock animals and mortality from respiratory diseases in The Netherlands: A prospective census-based cohort study

Author(s): Mariana Simões, Nicole Janssen, Dick Heederik, Lidwien Smit, Roel Vermeulen, Anke Huss
Published in: Environment International, Volume 161 / 2022, 2022, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2022.107140

Omicron SARS-CoV-2 epidemic in England during February 2022: A series of cross-sectional community surveys

Author(s): Chadeau-Hyam M, Tang D, Eales O, Bodinier B, Wang H, Jonnerby J, Whitaker M, Elliott J, Haw D, Walters CE, Atchison C, Diggle PJ, Page AJ, Ashby D, Barclay W, Taylor G, Cooke G, Ward H, Darzi A, Donnelly CA, Elliott P.
Published in: Lancet Regional Health Europe, 2022, ISSN 2666-7762
Publisher: Elsevier
DOI: 10.1016/j.lanepe.2022.100462

Modelling nationwide spatial variation of ultrafine particles based on mobile monitoring

Author(s): Jules Kerckhoffs, Gerard Hoek, Ulrike Gehring, Roel Vermeulen
Published in: Environment International, 154, 2021, Page(s) 106569, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106569

City-scale assessment of long-term air quality impacts on the respiratory and cardiovascular health

Author(s): Libor Šulc, Petr Gregor, Jirí Kalina, Ondrej Mikes, Tomás Janos and Pavel Cupr
Published in: Frontiers in Public Health, Volume 10 / 2022, 2022, ISSN 2296-2565
Publisher: Lausanne Frontiers Media S.A
DOI: 10.3389/fpubh.2022.1006536

Impact of long-term exposure to PM2.5 on peripheral blood gene expression pathways involved in cell signaling and immune response

Author(s): Jelle Vlaanderen, Roel Vermeulen, Matthew Whitaker, Marc Chadeau-Hyam, Jouke-Jan Hottenga, Eco de Geus, Gonneke Willemsen, Brenda W.J.H. Penninx, Rick Jansen, Dorret I. Boomsma,
Published in: Environment International, Volume 168 / 2022, 2022, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2022.107491

Air pollution, metabolites and respiratory health across the life-course

Author(s): Gruzieva O, Jeong A, He S, Yu Z, de Bont J, Pinho MGM, Eze IC, Kress S, Wheelock CE, Peters A, Vlaanderen J, de Hoogh K, Scalbert A, Chadeau-Hyam M, Vermeulen RCH, Gehring U, Probst-Hensch N, Melén E.
Published in: European respiratory review, Volume 31 / 2022, 2022, ISSN 1600-0617
Publisher: European respiratory society
DOI: 10.1183/16000617.0038-2022

COVID-19 mortality in the UK Biobank cohort: revisiting and evaluating risk factors

Author(s): Joshua Elliott, Barbara Bodinier, Matthew Whitaker, Cyrille Delpierre, Roel Vermeulen, Ioanna Tzoulaki, Paul Elliott, Marc Chadeau-Hyam
Published in: European Journal of Epidemiology, 36/3, 2021, Page(s) 299-309, ISSN 0393-2990
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10654-021-00722-y

Assessing How Social Exposures Are Integrated in Exposome Research: A Scoping Review

Author(s): Neufcourt L, Castagné R, Mabile L, Khalatbari-Soltani S, Delpierre C, Kelly-Irving M
Published in: Environmental Health Perspectives, Volume 130 / 2022, 2022, ISSN 0091-6765
Publisher: US Department of Health and Human Services
DOI: 10.1289/ehp11015

An annotation database for chemicals of emerging concern in exposome research

Author(s): Jeroen Meijer, Marja Lamoree, Timo Hamers, Jean-Philippe Antignac, Sébastien Hutinet, Laurent Debrauwer, Adrian Covaci, Carolin Huber, Martin Krauss, Douglas I. Walker, Emma L. Schymanski, Roel Vermeulen, Jelle Vlaanderen
Published in: Environment International, 152, 2021, Page(s) 106511, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106511

Where do Dutch adults obtain their snack foods? Cross-sectional exploration of individuals’ interactions with the food environment

Author(s): Mackenbach JD, Hobbs M, Pinho MGM
Published in: Health & Place, Volume 75 / 2022, 2022, ISSN 1353-8292
Publisher: Elsevier BV
DOI: 10.1016/j.healthplace.2022.102802

Prospective Identification of Elevated Circulating CDCP1 in Patients Years before Onset of Lung Cancer

Author(s): Sonia Dagnino, Barbara Bodinier, Florence Guida, Karl Smith-Byrne, Dusan Petrovic, Matthew D. Whitaker, Therese Haugdahl Nøst, Claudia Agnoli, Domenico Palli, Carlotta Sacerdote, Salvatore Panico, Rosario Tumino, Matthias B. Schulze, Mikael Johansson, Pekka Keski-Rahkonen, Augustin Scalbert, Paolo Vineis, Mattias Johansson, Torkjel M. Sandanger, Roel C.H. Vermeulen, Marc Chadeau-Hyam
Published in: Cancer Research, 81/13, 2021, Page(s) 3738-3748, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-20-3454

SARS-CoV-2 infection and vaccine effectiveness in England (REACT-1): a series of cross-sectional random community surveys.

Author(s): Chadeau-Hyam M, Wang H, Eales O, Haw D, Bodinier B, Whitaker M, Walters CE, Ainslie KEC, Atchison C, Fronterre C, Diggle PJ, Page AJ, Trotter AJ, Ashby D, Barclay W, Taylor G, Cooke G, Ward H, Darzi A, Riley S, Donnelly CA, Elliott P
Published in: The Lancet Respiratory Medicine, 2022, ISSN 2213-2600
Publisher: Elsevier Limited
DOI: 10.1016/s2213-2600(21)00542-7

Risk factors for positive and negative COVID-19 tests: a cautious and in-depth analysis of UK biobank data

Author(s): Marc Chadeau-Hyam, Barbara Bodinier, Joshua Elliott, Matthew D Whitaker, Ioanna Tzoulaki, Roel Vermeulen, Michelle Kelly-Irving, Cyrille Delpierre, Paul Elliott
Published in: International Journal of Epidemiology, 49/5, 2020, Page(s) 1454-1467, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyaa134

SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2.

Author(s): Eales O, Page AJ, de Oliveira Martins L, Wang H, Bodinier B, Haw D, Jonnerby J, Atchison C, Consortium C-GU, Ashby D, Barclay W, Taylor G, Cooke G, Ward H, Darzi A, Riley S, Chadeau-Hyam M, Donnelly CA, Elliott P.
Published in: BMC infectious diseases, Volume 22 / 2022, 2022, Page(s) 647, ISSN 1471-2334
Publisher: BioMed Central
DOI: 10.1186/s12879-022-07628-4

The exposome and health: Where chemistry meets biology

Author(s): Roel Vermeulen, Emma L. Schymanski, Albert-László Barabási, Gary W. Miller
Published in: Science, 367/6476, 2020, Page(s) 392-396, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aay3164

Invited Perspective: Inroads to Biology-Informed Exposomics

Author(s): Vermeulen R.
Published in: Environmental Health Perspectives, Volume 130 / 2022, 2022, ISSN 1552-9924
Publisher: JSTorg
DOI: 10.1289/ehp12224

Scrutinizing Privacy in Multi-Omics Research: How to Provide Ethical Grounding for the Identification of Privacy-Relevant Data Properties

Author(s): C.W. Safarlou, A.L. Bredenoord, R. Vermeulen & K.R. Jongsma
Published in: The American Journal of Bioethics, Volume 21, issue 12, 2021, Page(s) 73-75, ISSN 1526-5161
Publisher: MIT Press
DOI: 10.1080/15265161.2021.1991041

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