Objective Immune-mediated, non-communicable diseases, such as autoimmune diseases, allergic diseases and asthma, are chronic disorders in which the interaction between exposome and immune system plays a pivotal role. As prevalence and societal costs of these diseases are rising in the EU, a holistic approach is needed.The EXIMIOUS consortium—gathering high-level experts in immunology, toxicology, clinical medicine, environmental hygiene, epidemiology, bioinformatics and sensor development—will bring about a new way of assessing the human exposome by linking innovative ways of characterizing and quantifying multiple and combined environmental exposures (exposomics) with high-dimensional immunophenotyping and -profiling platforms to map the (early) immune effects induced by these exposures (immunomics). In several cohorts—covering the entire lifespan, including prenatal life—we will extensively map exposome, immune system (immunome), other omics and clinical and socio-economic data, using two main methodologies—one starting from the exposome, the other starting from health effects—that ‘meet in the middle’. Novel bioinformatics tools, based on systems immunology and machine learning, will be used to integrate and analyse these huge datasets and to construct ‘immune fingerprints’ that reflect a person’s lifetime exposome and identify ‘immune fingerprints’ that are early signs of poor health and predictors of disease at the individual level. We will build a multifaceted toolbox for researchers, policy makers, clinicians and the general public containing the exposome/immunome tools developed during the project to help assess the impact of the exposome on the immune system at the level of individuals and populations. This will allow policy makers to grasp the components of the exposome that needs to be prioritized to be able to design targeted preventive policies to reduce healthcare and socioeconomic costs, leading to greater wellbeing for the EU population.EXIMIOUS will work together with the other projects (EXPANSE, HEAP, ATHLETE, EQUAL-LIFE, LONGITOOLS, EPHOR, REMEDIA and HEDIMED) funded within the Human Exposome programme call H2020-SC1-BHC-2018-2020, in order to achieve collaboration and synergy. Fields of science medical and health sciencesclinical medicinepneumologyasthmamedical and health scienceshealth sciencespublic healthepidemiologymedical and health sciencesbasic medicineimmunologyautoimmune diseasesnatural sciencescomputer and information sciencesartificial intelligencemachine learningmedical and health sciencesbasic medicinetoxicology Keywords Immunomics Environment-immune-gene- Interaction Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.2. - Preventing disease Topic(s) SC1-BHC-28-2019 - The Human Exposome Project: a toolbox for assessing and addressing the impact of environment on health Call for proposal H2020-SC1-BHC-2018-2020 See other projects for this call Sub call H2020-SC1-2019-Single-Stage-RTD Funding Scheme RIA - Research and Innovation action Coordinator KATHOLIEKE UNIVERSITEIT LEUVEN Net EU contribution € 4 130 715,00 Address OUDE MARKT 13 3000 Leuven Belgium See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 4 130 715,00 Participants (15) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITEIT HASSELT Belgium Net EU contribution € 600 725,00 Address MARTELARENLAAN 42 3500 Hasselt See on map Region Vlaams Gewest Prov. Limburg (BE) Arr. Hasselt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 600 725,00 FOLKEHELSEINSTITUTTET Norway Net EU contribution € 1 336 685,00 Address LOVISENBERGGATA 8 0456 Oslo See on map Region Norge Oslo og Viken Oslo Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 336 685,00 DET NATIONALE FORSKNINGSCENTER FOR ARBEJDSMILJØ Denmark Net EU contribution € 664 875,00 Address LERSO PARKALLE 105 2100 Kobenhavn See on map Region Danmark Hovedstaden Byen København Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 664 875,00 BELGIAN CENTER FOR OCCUPATIONAL HYGIENE Belgium Net EU contribution € 911 271,25 Address TECHNOLOGIEPARK-ZWIJNAARDE 122 9052 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 911 271,25 INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM Belgium Net EU contribution € 461 025,00 Address KAPELDREEF 75 3001 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 461 025,00 UNIVERSITE CATHOLIQUE DE LOUVAIN Belgium Net EU contribution € 549 500,00 Address PLACE DE L UNIVERSITE 1 1348 Louvain La Neuve See on map Region Région wallonne Prov. Brabant Wallon Arr. Nivelles Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 549 500,00 THE BABRAHAM INSTITUTE Participation ended United Kingdom Net EU contribution € 111 437,60 Address Babraham Hall CB22 3AT Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 111 437,60 THE QUEEN'S UNIVERSITY OF BELFAST United Kingdom Net EU contribution € 158 457,50 Address UNIVERSITY ROAD LANYON BUILDING BT7 1NN Belfast See on map Region Northern Ireland Northern Ireland Belfast Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 158 457,50 REGION HOVEDSTADEN Denmark Net EU contribution € 172 000,00 Address KONGENS VAENGE 2 3400 Hillerod See on map Region Danmark Hovedstaden Nordsjælland Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 172 000,00 BIOGENITY APS Denmark Net EU contribution € 180 850,00 Address NIELS JERNES VEJ 10 9220 Aalborg Ost See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Danmark Nordjylland Nordjylland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 180 850,58 FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA Spain Net EU contribution € 395 500,00 Address PASSEIG VALL D HEBRON 119-129 EDIFICIO DE RECERCA 08035 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 395 500,00 AARHUS UNIVERSITET Denmark Net EU contribution € 67 150,00 Address NORDRE RINGGADE 1 8000 Aarhus C See on map Region Danmark Midtjylland Østjylland Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 67 150,00 "UNIVERSITATEA DE MEDICINA, FARMACIE, STIINTE SI TEHNOLOGIE ""GEORGE EMIL PALADE"" DIN TARGU MURES" Romania Net EU contribution € 771 437,50 Address STREET GHEORGHE MARINESCU 38 540139 Targu Mures See on map Region Macroregiunea Unu Centru Mureş Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 771 437,50 ACCELOPMENT SCHWEIZ AG Switzerland Net EU contribution € 221 890,00 Address SEEFELDSTRASSE 198 8008 ZURICH See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 221 890,00 THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom Net EU contribution € 144 812,40 Address TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 144 812,40