Mapping Exposure-Induced Immune Effects: Connecting the Exposome and the Immunome

Project Information

EXIMIOUS

Grant agreement ID: 874707

DOI

10.3030/874707

Project closed

EC signature date 6 December 2019

Start date 1 January 2020

End date 30 June 2025

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 10 878 331,83

EU contribution

€ 10 878 331,25

Coordinated by

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (2)

Report 7: Updated Dissemination and Communication strategy

Joint dissemination and communication activities for the network

Report 3 Handover document to next coordinating team

Document summarising network activities and ongoing activities to facilitate a smooth transition

Websites, patent fillings, videos etc. (2)

Project Website and online portal

Set up and maintain the project website including dedicated sections for stakeholders, such as scientific community, health practitioners, clinicians, health researchers, and the general public. The website will further feature all suitable dissemination and communication activities and resources, including guidance documents and links to social media channels. This is described in Task 7.3 WP7

Project Newsletter

WP7 Task 7.2 :Develop and distribute bi-annual project newsletters as of the second project year with information on project activities and discussions as well as news updates on relevant events and developments

Publications

Peer reviewed articles (30)

Exposure to silicates and systemic autoimmune-related outcomes in rodents: a systematic review

Author(s): Lisa M. F. Janssen; Manosij Ghosh; Frauke Lemaire; K. Michael Pollard; Peter H. M. Hoet
Published in: Particle and Fibre Toxicology, Issue 4, 2021, ISSN 1743-8977
Publisher: BioMed Central
DOI: 10.1186/s12989-021-00439-6

Short- and long-term pathologic responses to quartz are induced by nearly free silanols formed during crystal fracturing

Author(s): Cristina Pavan, Riccardo Leinardi, Anissa Benhida, Saloua Ibouraadaten, Yousof Yakoub, Sybille van den Brule, Dominique Lison, Francesco Turci, François Huaux
Published in: Particle and Fibre Toxicology, Issue 21, 2024, ISSN 1743-8977
Publisher: BioMed Central
DOI: 10.1186/s12989-024-00611-8

A cross-sectional study on occupational hygiene in biowaste plants

Author(s): Anne Mette Madsen, Pil Uthaug Rasmussen, Mohammad Seeiar Delsuz, Margit W Frederiksen
Published in: Annals of Work Exposures and Health, Issue 68, 2024, Page(s) 967-981, ISSN 2398-7308
Publisher: Oxford University Press (OUP)
DOI: 10.1093/annweh/wxae074

Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure

Author(s): Riccardo Leinardi; Amandine Pochet; Francine Uwambayinema; Yousof Yakoub; Valérie Quesniaux; Bernhard Ryffel; Petr Broz; Cristina Pavan; François Huaux
Published in: Archives of toxicology, Issue Vol. 97, no. 4, 2023, Page(s) p. 1001-1015, ISSN 1432-0738
Publisher: Springer Nature
DOI: 10.1007/s00204-023-03463-x

Carbon Nanotubes Under Scrutiny: Their Toxicity and Utility in Mesothelioma Research

Author(s): Micaela Orsi, Chafik Al Hatem, Riccardo Leinardi, François Huaux
Published in: Applied Sciences, Issue 10/13, 2020, Page(s) 4513, ISSN 2076-3417
Publisher: Applied Sciences
DOI: 10.3390/app10134513

Think Beyond Particle Cytotoxicity: When Self-Cellular Components Released After Immunogenic Cell Death Explain Chronic Disease Development

Author(s): Riccardo Leinardi; Chiara Longo Sanchez-Calero; François Huaux
Published in: Frontiers in Toxicology, Issue Vol. 4, no.1, 2022, Page(s) 1, ISSN 2673-3080
Publisher: Frontiers
DOI: 10.3389/ftox.2022.887228

ERS International Congress 2022: highlights from the Epidemiology and Environment Assembly

Author(s): James G.H. Parkin, Laura Delgado-Ortiz, Rosalie Delvert, Manosij Ghosh, Aliki Korkontzelou, Sarang Patil, Marine Savouré, Mateusz Jankowski, Orianne Dumas
Published in: ERJ Open Research, Issue 9, 2023, Page(s) 00574-2022, ISSN 2312-0541
Publisher: European Respiratory Society
DOI: 10.1183/23120541.00574-2022

A rapid test for the environmental detection of pigeon antigen

Author(s): Silvia Sánchez-Díez, María-Jesús Cruz, Daniel Álvarez-Simón, Tomás Montalvo, Xavier Muñoz, Peter M. Hoet, Jeroen A. Vanoirbeek, Susana Gómez-Ollés
Published in: Science of The Total Environment, Issue 788, 2021, Page(s) 147789, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2021.147789

Dynamic biodistribution of inhaled silica particles to extrapulmonary sites: Early and late translocation mechanisms with implication for particle biomonitoring

Author(s): Riccardo Leinardi, Chiara Longo Sanchez-Calero, Saloua Ibouraadaten, Francine Uwambayinema, Yousof Yakoub, Cristina Pavan, Rani Claus, Frauke Lemaire, Steven Ronsmans, Manosij Ghosh, Lénárd Farczádi, Horatiu Moldovan, Jeroen A.J. Vanoirbeek, Francesco Turci, Peter H.M. Hoet, François Huaux
Published in: Environment International, Issue 199, 2025, Page(s) 109473, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2025.109473

Insights From Early Clinical Trials Assessing Response to mRNA SARS-CoV-2 Vaccination in Immunocompromised Patients

Author(s): Frédéric Baron; Frédéric Baron; Lorenzo Canti; Kevin K. Ariën; Kevin K. Ariën; Delphine Kemlin; Isabelle Desombere; Margaux Gerbaux; Margaux Gerbaux; Pieter Pannus; Yves Beguin; Yves Beguin; Arnaud Marchant; Stéphanie Humblet-Baron
Published in: Frontiers in immunology, Issue Volume 13 - 2022, 2022, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.827242

The EXIMIOUS project—Mapping exposure-induced immune effects: connecting the exposome and the immunome

Author(s): Ronsmans, S; Sørig Hougaard, K; Nawrot, TS; Plusquin, M; Huaux, F; Jesús Cruz, M; Moldovan, H; Verpaele, S; Jayapala, Murali; Tunney, M; Humblet-Baron, Stephanie; Dirven, H; Cecilie Nygaard, U; Lindeman, B; Duale, N; Liston, Adrian; Meulengracht Flachs, E; Kastaniegaard, K; Ketzel, M; Goetz, J; Vanoirbeek, Jeroen; Ghosh, M; Hoet, Peter; The EXIMIOUS Consortium§
Published in: Environmental Epidemiology, 2022, ISSN 2474-7882
Publisher: Wolters Kluwer Health, Inc.
DOI: 10.1097/ee9.0000000000000193

Effects of different amosite preparations on macrophages, lung damages, and autoimmunity

Author(s): Alain Lescoat, Riccardo Leinardi, Kévin Pouxvielh, Yousof Yakoub, Marie Lelong, Amandine Pochet, Erwan Dumontet, Nessrine Bellamri, Erwan Le Tallec, Cristina Pavan, Francesco Turci, Christophe Paris, François Huaux, Valérie Lecureur
Published in: Journal of Molecular Medicine, Issue 102, 2024, Page(s) 197-211, ISSN 0946-2716
Publisher: Springer Verlag
DOI: 10.1007/s00109-023-02401-9

Distinct Pro-Inflammatory Mechanisms Elicited by Short and Long Amosite Asbestos Fibers in Macrophages

Author(s): Riccardo Leinardi, Jasmine Rita Petriglieri, Amandine Pochet, Yousof Yakoub, Marie Lelong, Alain Lescoat, Francesco Turci, Valérie Lecureur, François Huaux
Published in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242015145

External and internal exposome as triggers of biological signalling in systemic sclerosis – A narrative synthesis

Author(s): Lisa MF. Janssen, Frauke Lemaire, Chiara Longo Sanchez-Calero, François Huaux, Steven Ronsmans, Peter HM. Hoet, Manosij Ghosh
Published in: Journal of Autoimmunity, Issue 150, 2025, Page(s) 103342, ISSN 0896-8411
Publisher: Academic Press
DOI: 10.1016/j.jaut.2024.103342

Differential Pulmonary Toxicity and Autoantibody Formation in Genetically Distinct Mouse Strains Following Combined Exposure to Silica and Diesel Exhaust Particles

Author(s): Lisa MF Janssen; Frauke Lemaire; Nora Fopke Marain; Steven Ronsmans; Natasja Heylen; Arno Vanstapel; Greetje Vande Velde; Jeroen AJ Vanoirbeek; Kenneth Michael Pollard; Manosij Ghosh; Peter HM Hoet
Published in: Particle and Fibre Toxicology, Issue Vol 21, Iss 1, 2024, Page(s) 1-18, ISSN 1743-8977
Publisher: BioMed Central
DOI: 10.1186/s12989-024-00569-7

The exposome concept: how has it changed our understanding of environmental causes of chronic respiratory diseases?

Author(s): Alicia Guillien, Manosij Ghosh, Thomas Gille, Orianne Dumas
Published in: Breathe, Issue 19, 2023, Page(s) 230044, ISSN 1810-6838
Publisher: European Respiratory Society
DOI: 10.1183/20734735.0044-2023

Systems vaccinology identifies immunological correlates of SARS-CoV-2 vaccine response in solid organ transplant recipients

Author(s): Nicolas Gemander, Julika Neumann, Rafael Veiga, Isabelle Etienne, Teresa Prezzemolo, Delphine Kemlin, Pieter Pannus, Stéphanie Depickère, Véronique Olislagers, Inès Vu Duc, Alexandra Waegemans, Margaux Gerbaux, Leoni Bücken, Hafid Dahma, Charlotte Martin, Nicolas Dauby, Maria E. Goossens, Isabelle Desombere, Carlos P. Roca, Mathijs Willemsen, Stanislas Goriely, Alain Le Moine, Arnaud Marchant
Published in: npj Vaccines, Issue 10, 2025, ISSN 2059-0105
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41541-025-01182-1

B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles

Author(s): Léa Hiéronimus; François Huaux
Published in: Frontiers in toxicology, Issue Vol. 5, no.1, 2023, Page(s) 960861, ISSN 2673-3080
Publisher: Frontiers
DOI: 10.3389/ftox.2023.960861

AutoSpill is a principled framework that simplifies the analysis of multichromatic flow cytometry data

Author(s): Carlos P. Roca, Oliver T. Burton, Václav Gergelits, Teresa Prezzemolo, Carly E. Whyte, Richard Halpert, Łukasz Kreft, James Collier, Alexander Botzki, Josef Spidlen, Stéphanie Humblet-Baron, Adrian Liston
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23126-8

Human immune diversity: from evolution to modernity.

Author(s): Adrian Liston; Stephanie Humblet-Baron; Darragh Duffy; An Goris
Published in: Nature Immunology, 2021, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-021-01058-1

Fungal and bacterial species on biowaste workers’ hands and inhalation zone, and potential airway deposition

Author(s): Madsen, AM, Rasmussen, PU, Frederiksen, MW
Published in: Waste Management, Issue Volume 183, 30 June 2024, 2024, Page(s) 290-301, ISSN 0956-053X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.wasman.2024.05.018

Associations between occupational and environmental exposures and organ involvement in sarcoidosis: a retrospective case-case analysis

Author(s): Steven Ronsmans, Jolien De Ridder, Eline Vandebroek, Stephan Keirsbilck, Benoit Nemery, Peter H. M. Hoet, Steven Vanderschueren, Wim A. Wuyts, Jonas Yserbyt 
Published in: Respiratory Research, 2021, ISSN 1465-9921
Publisher: BioMed Central
DOI: 10.1186/s12931-021-01818-5

Uncovering exposome-related diseases through the pathologic metallome: a novel approach for clinical populations

Author(s): Riccardo Leinardi, François Huaux
Published in: Frontiers in Toxicology, Issue 7, 2025, ISSN 2673-3080
Publisher: Frontiers Media SA
DOI: 10.3389/ftox.2025.1625874

Monocytic Ontogeny of Regenerated Macrophages Characterizes the Mesotheliomagenic Responses to Carbon Nanotubes

Author(s): Micaela Orsi, Mihaly Palmai-Pallag, Yousof Yakoub, Saloua Ibouraadaten, Michèle De Beukelaer, Caroline Bouzin, Bertrand Bearzatto, Jérôme Ambroise, Jean-Luc Gala, Davide Brusa, Dominique Lison, François Huaux
Published in: Frontiers in Immunology, Issue 12, 2021, Page(s) 2303, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2021.666107

Data management and protection in occupational and environmental exposome research - A case study from the EU-funded EXIMIOUS project

Author(s): Ghosh, Manosij; Broothaerts, Katrijn; Ronsmans, Steven; Roig, Ingrid Barcena; Scheepers, Jef; Dikmen, Mustafa; Ciscato, Emily Rose; Blanch, Carolina; Plusquin, Michelle; Nygaard, Unni C.; Sejbaek, Camilla Sandal; Hougaard, Karin S.; Hoet, Peter HM.; EXIMIOUS Consortium
Published in: Environmental Research, Issue Volume 237, Part 1, 116886, 2023, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2023.116886

Occupational history of psychosocial work environment exposures and risk of autoimmune rheumatic diseases – a Danish register-based cohort study

Author(s): Helena Breth Nielsen, Camilla Sandal Sejbaek, Lene Wohlfahrt Dreyer, Ida EH Madsen, Esben Meulengracht Flachs, Karin Sørig Hougaard
Published in: Scandinavian Journal of Work, Environment & Health, Issue 51, 2025, Page(s) 226-236, ISSN 0355-3140
Publisher: Nordic Association of Occupational Safety and Health (NOROSH)
DOI: 10.5271/sjweh.4220

Occupational psychosocial stressors and ergonomic strain during pregnancy and sex-specific risk of childhood asthma

Author(s): Mette Møller Dornfeldt, Sandra Søgaard Tøttenborg, Esben Meulengracht Flachs, Luise Mølenberg Begtrup, Ida Elisabeth Huitfeldt Madsen, Karin Sørig Hougaard, Camilla Sandal Sejbaek
Published in: International Archives of Occupational and Environmental Health, Issue 98, 2025, Page(s) 13-23, ISSN 0340-0131
Publisher: Springer Verlag
DOI: 10.1007/s00420-024-02107-6

Interpreting Immunoregulation in Lung Fibrosis: A New Branch of the Immune Model

Author(s): François Huaux
Published in: Frontiers in Immunology, Issue Vol. 12, 2021, Page(s) 690375, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.690375

Mouse innate-like B-1 lymphocytes promote inhaled particle-induced in vitro granuloma formation and inflammation in conjunction with macrophages

Author(s): Léa Hiéronimus, Raïssa Demazy, Laura Christiaens, Francine Uwambayinema, Jean-François Geuens, Youssof Yacoub, François Huaux
Published in: Archives of Toxicology, Issue 96, 2022, Page(s) 585-599, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-021-03200-2

Comparison of a novel glove connector to chemical tape as a sealing device between gloves and protection suits

Author(s): Rani Claus, Wai Kei Chu, Luke D. Savory, Astrid Staelens, Katrien Poels, Mike Draper, Matteo Creta, Jeroen A.J. Vanoirbeek
Published in: Journal of Hazardous Materials, Issue 476, 2025, Page(s) 135186, ISSN 0304-3894
Publisher: Elsevier BV
DOI: 10.1016/j.jhazmat.2024.135186

Conference proceedings (5)

Compact high-speed snapshot multispectral imagers in the VIS/NIR (460-960 nm) and SWIR range (1.1-1.65 nm) and its potential in a diverse range of applications

Author(s): C. Blanch-Perez-del-Notario, B. Geelen, Y. Li, R. Vandebriel, J. Bentell, M. Jayapala and W. Charle
Published in: Proceedings of SPIE, Issue 12338, 2023
Publisher: SPIE
DOI: 10.1117/12.2664944

Hyperspectral microscopy as a particle exposure assessment tool

Author(s): C. Blanch-Perez-del-Notario, P. Bertier, M. Jayapala and A. Lambrechts
Published in: SPIE Photonics West 2024 Proceedings, 2024
Publisher: SPIE
DOI: 10.1117/12.3002829

O-60 FAIR data management in exposome research – a case study from the EU-funded EXIMIOUS project

Author(s): Manosij Ghosh; Katrijn Broothaerts; Steven Ronsmans; Ingrid Barcena Roig; Jef Scheepers; Mustafa Dikmen; Emily Rose Ciscato; Carolina Blanch; Michelle Plusquin; Unni C Nygaard; Camilla Sandal Sejbæk; Karin S Hougaard; Peter HM Hoet
Published in: FAIR data management in exposome research – a case study from the EU-funded EXIMIOUS project, Issue March 2023 - Volume 80 - Suppl 1, 2023
Publisher: Indian Association of Occupational Health
DOI: 10.1136/oem-2023-epicoh.203

Microplastic Discrimination with Hyperspectral Microscopy

Author(s): Carolina Blanch-Perez-Del-Notario, Aala Azari, Murali Jayapala, Andy Lambrechts
Published in: 2024 14th Workshop on Hyperspectral Imaging and Signal Processing: Evolution in Remote Sensing (WHISPERS), 2025, Page(s) 1-5
Publisher: IEEE
DOI: 10.1109/whispers65427.2024.10876553

Multispectral Snapshot Microscopy as an Exposure Assessment Tool

Author(s): Carolina Blanch-Perez-del-Notario, Amir Asadollahi, Pieter Bertier, Murali Jayapala
Published in: 2024 14th Workshop on Hyperspectral Imaging and Signal Processing: Evolution in Remote Sensing (WHISPERS), 2025, Page(s) 1-5
Publisher: IEEE
DOI: 10.1109/whispers65427.2024.10876513

Other (4)

<b>Study protocol: Physical work demands and risk of rheumatoid arthritis, systemic sclerosis and systemic lupus erythematosus. A study protocol from the EU-funded EXIMIOUS project.</b>

Author(s): Breth Nielsen, Helena; Gupta, Nidhi; Andersen, Astrid Juhl; Dreyer, Lene W.; Flachs, Esben Meulengracht; Madsen, Ida E. H.; Kolstad, Henrik A.; Kromhout, Hans; Sejbaek, Camilla Sandal; Hougaard, Karin Sørig
Published in: Issue 2, 2025
Publisher: figshare
DOI: 10.6084/m9.figshare.29136848

<b>Study protocol for analyses of the association between psychosocial work environment exposures and risk of autoimmune rheumatic diseases. A study protocol from the EU-funded EXIMIOUS project</b>

Author(s): Breth Nielsen, Helena; Sejbæk, Camilla Sandal; Dreyer, Lene Wohlfahrt; Madsen, Ida E.H.; Flachs, Esben Meulengracht; Hougaard, Karin Sørig
Published in: Issue 2, 2023
Publisher: Figshare
DOI: 10.6084/m9.figshare.24745563

EXIMIOUS SOP for collection, storage and shipment of biological samples (updated version 3)

Author(s): Nygaard, Unni; Ghosh, Manosij; Humblet-Baron, Stephanie; Nawrot, Tim; Sarah Elisabet Josefsson; Plusquin, Michelle; Huaux, François; Vanoirbeek, Jeroen; Dirven, Hubert; Rasmussen, Pil Uthaug; Cruz, María-Jesus; Claus, Rani; Lindeman, Birgitte; Broothaerts, Katrijn; Hoet, Peter
Published in: 2022
Publisher: KU Leuven RDR
DOI: 10.48804/amzhsd

Study protocol: Analysis of the association between occupational wood dust exposure and risk of rheumatoid arthritis

Author(s): Andersen, A.J., Nielsen, H.B., Flachs, E.M., Vogel, U., Madsen, I.E.H., Bonde, J.P., Hoet, P., Ronsmans, S., Ghosh, M., Kromhout, H., Peters, S., Ohlander, J., Kolstad, H.A., Basinas, I., Schlünssen, V., Sejbæk, C.S., Hougaard, K.S
Published in: 2025
Publisher: figshare
DOI: 10.6084/m9.figshare.29423693.v1

Thesis and dissertations (1)

Characterization of a new intermediate macrophage subpopulation: SDC-1 positive SPM-like macrophages possess immunosuppressive functions in early mesotheliomagenic responses to carbon nanotubes

Author(s): Micaela Orsi
Published in: 2021
Publisher: UCL