CORDIS
EU research results

CORDIS

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Novel Strategies for Cell-based Neural Reconstruction

Project information

Grant agreement ID: 874758

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2023

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 8 169 231,25

  • EU contribution

    € 8 168 495

Coordinated by:

UNIVERSITA DEGLI STUDI DI MILANO

Italy

Objective

Neurodegenerative diseases and brain injuries affect large patient groups and carry large unmet clinical needs. NSC-Reconstruct will respond to these needs by developing innovative therapies based on cell replacement, cell reprogramming and circuit reconstruction that have the potential to transform how we treat a wide range of neurological diseases and disorders.
In this area of clinical science European research has generated groundbreaking knowledge that has resulted in a pioneering human embryonic stem cell-derived product that is now entering clinical trials for Parkinson’s Disease (PD). In NSC-Reconstruct we will move beyond the replacement of a single neuronal type towards future cell therapies with enhanced authenticity, functions and compositions.
NSC-Reconstruct will address PD as an example of disorder for which single neuron replacement has been developed. Our focus in PD will be on incorporating improved cell types and on local network reconstruction. We will also work on repairing long distance networks such as those affected in Huntington’s disease and finally in restoring the complex networks and projections of the cerebral cortex to achieve effective repair in conditions known to affect this structure, such as trauma or stroke.
NSC-Reconstruct will lead to (i) the generation of neuronal types with clinically relevant functionality starting from human pluripotent stem cells or through in situ reprogramming, (ii) the optimization of donor cell composition through grafting of functional modules comprising distinct cell types capable of forming appropriate connections, (iii) the restoration of function through the reconstruction of these damaged connections and finally (iv) a greater understanding of the immunogenicity of grafted cells and how this can be minimized.
Ultimately, NSC-Reconstruct will provide unique knowledge and products that will pave the way for future CNS cell replacement therapies using functionally enhanced and immune-tolerant cells.
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Coordinator

UNIVERSITA DEGLI STUDI DI MILANO

Address

Via Festa Del Perdono 7
20122 Milano

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 518 495

Participants (12)

LUNDS UNIVERSITET

Sweden

EU Contribution

€ 930 000

UNIVERSITAETSKLINIKUM BONN

Germany

EU Contribution

€ 680 000

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 680 000

UNIVERSITA DEGLI STUDI DI TORINO

Italy

EU Contribution

€ 780 000

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 680 000

KOBENHAVNS UNIVERSITET

Denmark

EU Contribution

€ 400 000

CARDIFF UNIVERSITY

United Kingdom

EU Contribution

€ 500 000

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

EU Contribution

€ 500 000

VIB

Belgium

EU Contribution

€ 500 000

MILTENYI BIOTEC GMBH

Germany

EU Contribution

€ 400 000

LIFE AND BRAIN GMBH

Germany

EU Contribution

€ 300 000

NOVO NORDISK A/S

Denmark

EU Contribution

€ 300 000

Project information

Grant agreement ID: 874758

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2023

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 8 169 231,25

  • EU contribution

    € 8 168 495

Coordinated by:

UNIVERSITA DEGLI STUDI DI MILANO

Italy