Indo-European Consortium for Next Generation Influenza Vaccine Innovation

Project description

Next-generation influenza vaccines

The strategic goals of the EU-funded INCENTIVE project are to advance knowledge of the underlying mechanisms of poor responsiveness to influenza vaccines (IVs) and to develop two next-generation universal IVs. This is a partnership between Indian, European and US groups that address the global health and economic challenge posed by influenza infections. The objectives include: performing comprehensive profiling of responders and non-responders to licensed IVs in infants, children, adults and elderly in phase IV trials in Europe and India to identify the mechanisms of vaccine responsiveness; advancing the development of two next-generation vaccines by providing a proof-of-concept for vaccine efficacy in non-human primates for an antigen presenting cell-targeted nucleic acid vaccine and developing a computationally-optimized vaccine up to phase II clinical trials and vaccine efficacy in a controlled human challenge; identifying predictive biomarkers of responsiveness to vaccination for new diagnostics; implementing technology transfer; and performing a health systems and investment analysis.

Fields of science

• medical and health sciences › health sciences › infectious disease › RNA virus › influenza
• natural sciences › biological sciences › zoology › mammalogy › primatology
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drug › vaccines
• natural sciences › biological sciences › biochemistry › biomolecules › nucleic acid

Programme(s)

• H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being
• H2020-EU.3.1.2. - Preventing disease

Topic(s)

• SC1-BHC-32-2019 - Towards a next generation influenza vaccine to protect citizens worldwide – an EU-India collaboration

Call for proposal

H2020-SC1-2019-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH

Address

Inhoffenstrasse 7
38124 Braunschweig
Germany

Activity type

Research Organisations

EU contribution

€ 2 537 797,50

Participants (18)

PUBLIC HEALTH FOUNDATION OF INDIA

India

EU contribution

€ 0

Address

Unit 431A, 4Th Floor, Rectangle-1 Building Plot D-4, District Centre Saket
110017 New Delhi

Activity type

Research Organisations

TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE

India

EU contribution

€ 0

Address

Ncr Biotech Science Cluster 3Rd Milestone Haryana
121001 Faridabad

Activity type

Research Organisations

UNIVERSITE LIBRE DE BRUXELLES

Belgium

EU contribution

€ 614 963,75

Address

Avenue Franklin Roosevelt 50
1050 Bruxelles

Activity type

Higher or Secondary Education Establishments

UNIVERSITETET I BERGEN

Norway

EU contribution

€ 567 296,25

Address

Museplassen 1
5020 Bergen

Activity type

Higher or Secondary Education Establishments

UNIVERSITETET I OSLO

Norway

EU contribution

€ 307 086,25

Address

Problemveien 5-7
0313 Oslo

Activity type

Higher or Secondary Education Establishments

UNIVERSITEIT ANTWERPEN

Belgium

EU contribution

€ 919 943,75

Address

Prinsstraat 13
2000 Antwerpen

Activity type

Higher or Secondary Education Establishments

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU contribution

€ 1 003 785

Address

Albinusdreef 2
2333 ZA Leiden

Activity type

Higher or Secondary Education Establishments

INSTITUT PASTEUR

France

EU contribution

€ 441 260

Address

Rue Du Docteur Roux 25-28
75724 Paris Cedex 15

Activity type

Research Organisations

ASA SPEZIALENZYME GMBH

Germany

EU contribution

€ 387 750

Address

Am Exer 19 C
38302 Wolfenbuttel

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA

Spain

EU contribution

€ 383 670

Address

C Rossello 132 Planta 05
08036 Barcelona

Activity type

Research Organisations

BIOASTER FONDATION DE COOPERATION SCIENTIFIQUE

France

EU contribution

€ 531 858,75

Address

40 Avenue Tony Garnier
69007 Lyon

Activity type

Research Organisations

UGA RESEARCH FOUNDATION INC NON PROFIT CORP

United States

EU contribution

€ 586 990

Address

150D Paul D. Coverdell Center 500 Dw Brooks Drive
30602-7411 Athens

Activity type

Research Organisations

STICHTING HUMAN VACCINES PROJECT EUROPE

Netherlands

EU contribution

€ 794 312,50

Address

Brakersweg 53
1901 XX Castricum

Activity type

Other

EUROVACC FOUNDATION

Switzerland

EU contribution

€ 136 875

Address

Place Saint-francois 1 Etude Kellerhals Carrard
1003 Lausanne

Activity type

Other

HUMAN VACCINES PROJECT, INC

United States

EU contribution

€ 760 705

Address

251 Little Falls Drive
19808 Wilmington New Castle

Activity type

Other

INDIAN INSTITUTE OF TECHNOLOGY MADRAS (IITM)

India

EU contribution

€ 0

Address

Centre For Industrial Consultancy And Sponsored Research Indian Institute If Technology Madras
600036 Chennai

Activity type

Higher or Secondary Education Establishments

SETH G S M COLLEGE AND K E M HOSPITAL DIAMOND JUBILEE SOCIETY

India

EU contribution

€ 0

Address

Acharya Donde Marg Parel
400012 Mumbai

Activity type

Research Organisations

NATIONAL INSTITUTE OF IMMUNOLOGY SOCIETY

India

EU contribution

€ 0

Address

Aruna Asaf Ali Marg
110067 New Delhi

Activity type

Research Organisations