Indo-European Consortium for Next Generation Influenza Vaccine Innovation

Informations projet

INCENTIVE

N° de convention de subvention: 874866

DOI

10.3030/874866

Date de signature de la CE 13 Decembre 2019

Date de début 1 Août 2020

Date de fin 31 Janvier 2026

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 19 965 992,50

Contribution de l’UE

€ 9 974 293,75

Coordonné par

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (2)

INCENTIVE-QIV-1,2,3 (EU) and QIV-1 (India): Study results posted in the study registry

Safety and preliminary immunogenicity results posted on the study registry. Timelines if/when final posting of results is scheduled after end of funding period will be included.

INCENTIVE-QIV: Registration of the clinical trial in the trial registry

Study registered at a WHO or ICMJapproved registry

Websites, patent fillings, videos etc. (1)

Project presentation prepared, website launched and communication plan developed

Setting up consortium website public and secured intranet Communication plan regulating the consortium communication

Publications

Peer reviewed articles (32)

Human Organotypic Airway and Lung Organoid Cells of Bronchiolar and Alveolar Differentiation Are Permissive to Infection by Influenza and SARS-CoV-2 Respiratory Virus

Auteurs: Camilla Tvedt Ekanger, Fan Zhou, Dana Bohan, Maria Lie Lotsberg, Maria Ramnefjell, Laurence Hoareau, Gro Vatne Røsland, Ning Lu, Marianne Aanerud, Fabian Gärtner, Pirjo Riitta Salminen, Mariann Bent
Publié dans: Frontiers in Cellular and Infection Microbiology, Numéro 12, 2022, Page(s) 841447, ISSN 2235-2988
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fcimb.2022.841447

SARS-CoV-2–Specific Neutralizing Antibody Responses in Norwegian Health Care Workers After the First Wave of COVID-19 Pandemic: A Prospective Cohort Study

Auteurs: Mai-Chi Trieu, Amit Bansal, Anders Madsen, Fan Zhou, Marianne Sævik, Juha Vahokoski, Karl Albert Brokstad, Florian Krammer, Camilla Tøndel, Kristin G I Mohn, Bjørn Blomberg, Nina Langeland, Rebecca
Publié dans: The Journal of Infectious Diseases, Numéro 223, 2021, Page(s) 589-599, ISSN 0022-1899
Éditeur: University of Chicago Press
DOI: 10.1093/infdis/jiaa737

Post COVID-19 condition after delta infection and omicron reinfection in children and adolescents

Auteurs: Nina Urke Ertesvåg, Arild Iversen, Bjørn Blomberg, Türküler Özgümüş, Pramila Rijal, Elisabeth Berg Fjelltveit, Rebecca Jane Cox, Nina Langeland, Kjell Haug, Helene Sandnes, Kristin G-I Mohn, J
Publié dans: eBioMedicine, Numéro 92, 2025, Page(s) 104599, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104599

Seasonal influenza vaccination expands hemagglutinin-specific antibody breadth to older and future A/H3N2 viruses

Auteurs: Nina Urke Ertesvåg, Rebecca Jane Cox, Sarah Larteley Lartey, Kristin G-I Mohn, Karl Albert Brokstad, Mai-Chi Trieu
Publié dans: npj Vaccines, Numéro 7, 2022, Page(s) 490, ISSN 2059-0105
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s41541-022-00490-0

Intranasal administration of octavalent next-generation influenza vaccine elicits protective immune responses against seasonal and pre-pandemic viruses

Auteurs: Naoko Uno, Thomas Ebensen, Carlos A. Guzman, Ted M. Ross
Publié dans: Journal of Virology, Numéro 98, 2024, ISSN 0022-538X
Éditeur: American Society for Microbiology
DOI: 10.1128/jvi.00354-24

Effects of repeated influenza vaccination and infection on durable seroprotection in healthcare workers

Auteurs: Mai-Chi Trieu, Amit Bansal, Marianne Sævik, Sonja Ljostveit, Åsne Jul-Larsen, Rebecca Jane Cox
Publié dans: npj Vaccines, Numéro 10, 2025, Page(s) 1259, ISSN 2059-0105
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s41541-025-01259-x

Influenza hemagglutinin and neuraminidase multivalent vaccine elicits broader protective immune responses compared to vaccine formulations composed of hemagglutinin or neuraminidase

Auteurs: Naoko Uno, Ted M. Ross
Publié dans: Human Vaccines & Immunotherapeutics, Numéro 21, 2026, Page(s) 259961, ISSN 2164-5515
Éditeur: Landes Bioscience
DOI: 10.1080/21645515.2025.2599611

Repeated Influenza Vaccination Boosts and Maintains H1N1pdm09 Neuraminidase Antibody Titers

Auteurs: Lena Hansen, Fan Zhou, Håkon Amdam, Mai-Chi Trieu, Rebecca Jane Cox
Publié dans: Frontiers in Immunology, Numéro 12, 2021, Page(s) 748264, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2021.748264

Impact of Pre-Existing Immunity and Age on Antibody Responses to Live Attenuated Influenza Vaccine

Auteurs: Lukas Hoen, Sarah Lartey, Fan Zhou, Rishi D. Pathirana, Florian Krammer, Kristin G -I Mohn, Rebecca J. Cox, Karl A. Brokstad
Publié dans: Vaccines, Numéro 12, 2025, Page(s) 864, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines12080864

Matrix M Adjuvanted H5N1 Vaccine Elicits Broadly Neutralizing Antibodies and Neuraminidase Inhibiting Antibodies in Humans That Correlate With In Vivo Protection

Auteurs: Fan Zhou, Lena Hansen, Gabriel Pedersen, Gunnveig Grødeland, Rebecca Cox
Publié dans: Frontiers in Immunology, Numéro 12, 2021, Page(s) 747774, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2021.747774

Impact of ageing on homologous and human-coronavirus-reactive antibodies after SARS-CoV-2 vaccination or infection

Auteurs: Fan Zhou, Juha Vahokoski, null null, Siri Øyen, Marianne Sævik, Hanne Høyland, Helene H. Sandnes, Anders Madsen, Karl A. Brokstad, Kristin G. I. Mohn, Camilla Tøndel, Nina Langeland, Rebecca J. Co
Publié dans: npj Vaccines, Numéro 9, 2024, Page(s) 817, ISSN 2059-0105
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s41541-024-00817-z

SARS-CoV-2 infection induces long-lived B and T-cell responses up to 15 months post-infection, irrespective of disease severity

Auteurs: Kristin G.-I. Mohn, Geir Bredholt, Therese Bredholt Onyango, Karl A. Brokstad, Fan Zhou, Jan Cato Holter, Kristian Tonby, Anne Ma Dyrhol-Riise, Rebecca Jane Cox
Publié dans: Journal of Infection, Numéro 87, 2025, Page(s) 346-349, ISSN 0163-4453
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2023.05.023

A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern

Auteurs: Nina Urke Ertesvåg, Julie Xiao, Fan Zhou, Sonja Ljostveit, Helene Sandnes, Sarah Lartey, Marianne Sævik, Lena Hansen, Anders Madsen, Kristin G. I. Mohn, Elisabeth Fjelltveit, Jan Stefan Olofsson, Ti
Publié dans: Communications Medicine, Numéro 2, 2022, Page(s) 91, ISSN 2730-664X
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s43856-022-00091-x

Vaccination prevents severe COVID-19 outcome in patients with neutralizing type 1 interferon autoantibodies

Auteurs: Anette S.B. Wolff, Lena Hansen, Marianne Aa. Grytaas, Bergithe E. Oftedal, Lars Breivik, Fan Zhou, Karl Ove Hufthammer, Thea Sjøgren, Jan Stefan Olofsson, Mai Chi Trieu, Anthony Meager, Anders P. Jø
Publié dans: iScience, Numéro 26, 2024, Page(s) 107084, ISSN 2589-0042
Éditeur: Elsevier BV
DOI: 10.1016/j.isci.2023.107084

Symptom Burden and Immune Dynamics 6 to 18 Months Following Mild Severe Acute Respiratory Syndrome Coronavirus 2 Infection (SARS-CoV-2): A Case-control Study

Auteurs: Elisabeth B Fjelltveit, Bjørn Blomberg, Kanika Kuwelker, Fan Zhou, Therese B Onyango, Karl A Brokstad, Rebecca Elyanow, Ian M Kaplan, Camilla Tøndel, Kristin G I Mohn, Türküler Özgümüş, Rebecc
Publié dans: Clinical Infectious Diseases, Numéro 76, 2023, Page(s) e60-e70, ISSN 1058-4838
Éditeur: University of Chicago Press
DOI: 10.1093/cid/ciac655

Next Generation Influenza Vaccines: Looking into theCrystal Ball

Auteurs: Carlos Alberto Guzmán
Publié dans: Vaccines, 2020, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8030464

Risk assessment and antibody responses to SARS-CoV-2 in healthcare workers

Auteurs: Amit Bansal, Mai-Chi Trieu, Kristin G. I. Mohn, Anders Madsen, Jan Stefan Olofsson, Helene Heitmann Sandnes, Marianne Sævik, Hanne Søyland, Lena Hansen, Therese Bredholt Onyango, Camilla Tøndel, Ka
Publié dans: Frontiers in Public Health, Numéro 11, 2023, Page(s) 1164326, ISSN 2296-2565
Éditeur: Frontiers Media SA
DOI: 10.3389/fpubh.2023.1164326

Symptom trajectories of post-COVID sequelae in patients with acute Delta or Omicron infection in Bergen, Norway

Auteurs: Arild Iversen, Bjørn Blomberg, Kjell Haug, Bård Kittang, Türküler Özgümüs, Rebecca Jane Cox, Nina Langeland
Publié dans: Frontiers in Public Health, Numéro 12, 2024, Page(s) 1320059, ISSN 2296-2565
Éditeur: Frontiers Media SA
DOI: 10.3389/fpubh.2024.1320059

Perceived infection risk, infection exposure, and compliance to infection control measures among the first COVID-19 patients in Norway

Auteurs: Bjørn Sætrevik, Rebecca J. Cox, Dagrun W. Linchausen, Sebastian B. Bjørkheim
Publié dans: Scandinavian Journal of Public Health, Numéro 53, 2026, Page(s) 517-524, ISSN 1403-4948
Éditeur: SAGE Publications
DOI: 10.1177/14034948251315341

SARS-CoV-2 specific immune responses in overweight and obese COVID-19 patients

Auteurs: Therese Bredholt Onyango, Fan Zhou, Geir Bredholt, Karl A. Brokstad, Sarah Lartey, Kristin G.-I. Mohn, Türküler Özgümüs, Bård Reiakvam Kittang, Dagrun Waag Linchausen, Shahin Shafiani, Rebecca E
Publié dans: Frontiers in Immunology, Numéro 14, 2023, Page(s) 1287388, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2023.1287388

Three Doses of Sars-Cov-2 Mrna Vaccine in Older Adults Result in Similar Antibody Responses But Reduced Cellular Cytokine Responses Relative to Younger Adults

Auteurs: Geir Bredholt, Marianne Sævik, Hanne Søyland, Thor Ueland, Fan Zhou, Rishi Pathirana, Anders Madsen, Juha Vahokoski, Sarah Lartey Jalloh, Bente Halvorsen, Tuva Børresdatter Dahl, Mai Chi T. Trieu,
Publié dans: Vaccine: X, Numéro 20, 2024, Page(s) 100564, ISSN 2590-1362
Éditeur: Elsevier BV
DOI: 10.2139/ssrn.4915330

Durable T-cellular and humoral responses in SARS-CoV-2 hospitalized and community patients

Auteurs: Kristin G.-I. Mohn, Geir Bredholt, Fan Zhou, Anders Madsen, Therese B. Onyango, Elisabeth B. Fjelltveit, Sarah L. Jalloh, Karl A. Brokstad, Diego Cantoni, Martin Mayora-Neto, Nigel Temperton, Nina Lan
Publié dans: PLOS ONE, Numéro 17, 2022, Page(s) e0261979, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0261979

Point-of-Care Influenza Testing Impacts Clinical Decision, Patient Flow, and Length of Stay in Hospitalized Adults

Auteurs: Elisabeth B Fjelltveit, Rebecca J Cox, Jørgen Østensjø, Bjørn Blomberg, Marit H Ebbesen, Nina Langeland, Kristin G I Mohn
Publié dans: The Journal of Infectious Diseases, Numéro 226, 2022, Page(s) 97-108, ISSN 0022-1899
Éditeur: University of Chicago Press
DOI: 10.1093/infdis/jiaa690

Safety, Immunogenicity, Efficacy and Effectiveness of Inactivated Influenza Vaccines in Healthy Pregnant Women and Children Under 5 Years: An Evidence-Based Clinical Review

Auteurs: Amit Bansal, Mai-Chi Trieu, Kristin G. I. Mohn, Rebecca Jane Cox
Publié dans: Frontiers in Immunology, Numéro 12, 2021, Page(s) 744774, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2021.744774

SARS-CoV-2 infection rates and associated risk factors in healthcare workers: systematic review and meta-analysis

Auteurs: Amit Bansal, Mai-Chi Trieu, Emily M. Eriksson, Fan Zhou, Jodie McVernon, Karl Albert Brokstad, Rebecca Jane Cox
Publié dans: Scientific Reports, Numéro 15, 2025, Page(s) 4705, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-025-89472-5

Durable immune responses after BNT162b2 vaccination in home-dwelling old adults

Auteurs: Lena Hansen, Karl Albert Brokstad, Amit Bansal, Fan Zhou, Geir Bredholt, Therese Bredholt Onyango, Helene Heitmann Sandnes, Rebecca Elyanow, Anders Madsen, Mai-Chi Trieu, Marianne Sævik, Hanne Søyla
Publié dans: Vaccine: X, Numéro 13, 2025, Page(s) 100262, ISSN 2590-1362
Éditeur: Elsevier BV
DOI: 10.1016/j.jvacx.2023.100262

Multivalent next generation influenza virus vaccines protect against seasonal and pre-pandemic viruses

Auteurs: Naoko Uno, Ted M. Ross
Publié dans: Scientific Reports, Numéro 14, 2024, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-51024-0

Targeted barcoding of variable antibody domains and individual transcriptomes of the human B-cell repertoire using Link-Seq

Auteurs: Hongxing Hu, Fan Zhou, Xiaoli Ma, Karl Albert Brokstad, Leonie Kolmar, Charles Girardot, Vladimir Benes, Rebecca J Cox, Christoph A Merten
Publié dans: PNAS Nexus, Numéro 4, 2025, Page(s) 6, ISSN 2752-6542
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/pnasnexus/pgaf006

Long COVID in a prospective cohort of home-isolated patients

Auteurs: Bjørn Blomberg, Kristin Greve-Isdahl Mohn, Karl Albert Brokstad, Fan Zhou, Dagrun Waag Linchausen, Bent-Are Hansen, Sarah Lartey, Therese Bredholt Onyango, Kanika Kuwelker, Marianne Sævik, Hauke Bar
Publié dans: Nature Medicine, Numéro 27, 2021, Page(s) 1607-1613, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-021-01433-3

Not just antibodies: B cells and T cells mediate immunity to COVID-19

Auteurs: Rebecca J. Cox, Karl A. Brokstad
Publié dans: Nature Reviews Immunology, Numéro 20, 2021, Page(s) 581-582, ISSN 1474-1733
Éditeur: Nature Publishing Group
DOI: 10.1038/s41577-020-00436-4

Prospects and Challenges in the Development of Universal Influenza Vaccines

Auteurs: Anders Madsen, Rebecca Jane Cox
Publié dans: Vaccines, Numéro 8, 2025, Page(s) 361, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8030361

Markers of T cell activation and exhaustion in plasma are associated with persistent symptoms up to 18 months following mild SARS-CoV-2 infection

Auteurs: Thor Ueland, Rebecca Jane Cox, Annika E. Michelsen, Elisabeth Berg Fjelltveit, Kari Otterdal, Tuva Dahl, Fan Zhou, Rebecca Elyanow, Pål Aukrust, Bjørn Blomberg, Bente E. Halvorsen, Nina Langeland
Publié dans: Frontiers in Immunology, Numéro 16, 2025, Page(s) 1578208, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1578208