Indo-European Consortium for Next Generation Influenza Vaccine Innovation

Informazioni relative al progetto

INCENTIVE

ID dell’accordo di sovvenzione: 874866

DOI

10.3030/874866

Data della firma CE 13 Dicembre 2019

Data di avvio 1 Agosto 2020

Data di completamento 31 Gennaio 2026

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 19 965 992,50

Contributo UE

€ 9 974 293,75

Coordinato da

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (2)

INCENTIVE-QIV-1,2,3 (EU) and QIV-1 (India): Study results posted in the study registry

Safety and preliminary immunogenicity results posted on the study registry. Timelines if/when final posting of results is scheduled after end of funding period will be included.

INCENTIVE-QIV: Registration of the clinical trial in the trial registry

Study registered at a WHO or ICMJapproved registry

Websites, patent fillings, videos etc. (1)

Project presentation prepared, website launched and communication plan developed

Setting up consortium website public and secured intranet Communication plan regulating the consortium communication

Pubblicazioni

Peer reviewed articles (32)

Human Organotypic Airway and Lung Organoid Cells of Bronchiolar and Alveolar Differentiation Are Permissive to Infection by Influenza and SARS-CoV-2 Respiratory Virus

Autori: Camilla Tvedt Ekanger, Fan Zhou, Dana Bohan, Maria Lie Lotsberg, Maria Ramnefjell, Laurence Hoareau, Gro Vatne Røsland, Ning Lu, Marianne Aanerud, Fabian Gärtner, Pirjo Riitta Salminen, Mariann Bent
Pubblicato in: Frontiers in Cellular and Infection Microbiology, Numero 12, 2022, Pagina/e 841447, ISSN 2235-2988
Editore: Frontiers Media S. A.
DOI: 10.3389/fcimb.2022.841447

SARS-CoV-2–Specific Neutralizing Antibody Responses in Norwegian Health Care Workers After the First Wave of COVID-19 Pandemic: A Prospective Cohort Study

Autori: Mai-Chi Trieu, Amit Bansal, Anders Madsen, Fan Zhou, Marianne Sævik, Juha Vahokoski, Karl Albert Brokstad, Florian Krammer, Camilla Tøndel, Kristin G I Mohn, Bjørn Blomberg, Nina Langeland, Rebecca
Pubblicato in: The Journal of Infectious Diseases, Numero 223, 2021, Pagina/e 589-599, ISSN 0022-1899
Editore: University of Chicago Press
DOI: 10.1093/infdis/jiaa737

Post COVID-19 condition after delta infection and omicron reinfection in children and adolescents

Autori: Nina Urke Ertesvåg, Arild Iversen, Bjørn Blomberg, Türküler Özgümüş, Pramila Rijal, Elisabeth Berg Fjelltveit, Rebecca Jane Cox, Nina Langeland, Kjell Haug, Helene Sandnes, Kristin G-I Mohn, J
Pubblicato in: eBioMedicine, Numero 92, 2025, Pagina/e 104599, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104599

Seasonal influenza vaccination expands hemagglutinin-specific antibody breadth to older and future A/H3N2 viruses

Autori: Nina Urke Ertesvåg, Rebecca Jane Cox, Sarah Larteley Lartey, Kristin G-I Mohn, Karl Albert Brokstad, Mai-Chi Trieu
Pubblicato in: npj Vaccines, Numero 7, 2022, Pagina/e 490, ISSN 2059-0105
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41541-022-00490-0

Intranasal administration of octavalent next-generation influenza vaccine elicits protective immune responses against seasonal and pre-pandemic viruses

Autori: Naoko Uno, Thomas Ebensen, Carlos A. Guzman, Ted M. Ross
Pubblicato in: Journal of Virology, Numero 98, 2024, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/jvi.00354-24

Effects of repeated influenza vaccination and infection on durable seroprotection in healthcare workers

Autori: Mai-Chi Trieu, Amit Bansal, Marianne Sævik, Sonja Ljostveit, Åsne Jul-Larsen, Rebecca Jane Cox
Pubblicato in: npj Vaccines, Numero 10, 2025, Pagina/e 1259, ISSN 2059-0105
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41541-025-01259-x

Influenza hemagglutinin and neuraminidase multivalent vaccine elicits broader protective immune responses compared to vaccine formulations composed of hemagglutinin or neuraminidase

Autori: Naoko Uno, Ted M. Ross
Pubblicato in: Human Vaccines & Immunotherapeutics, Numero 21, 2026, Pagina/e 259961, ISSN 2164-5515
Editore: Landes Bioscience
DOI: 10.1080/21645515.2025.2599611

Repeated Influenza Vaccination Boosts and Maintains H1N1pdm09 Neuraminidase Antibody Titers

Autori: Lena Hansen, Fan Zhou, Håkon Amdam, Mai-Chi Trieu, Rebecca Jane Cox
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, Pagina/e 748264, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2021.748264

Impact of Pre-Existing Immunity and Age on Antibody Responses to Live Attenuated Influenza Vaccine

Autori: Lukas Hoen, Sarah Lartey, Fan Zhou, Rishi D. Pathirana, Florian Krammer, Kristin G -I Mohn, Rebecca J. Cox, Karl A. Brokstad
Pubblicato in: Vaccines, Numero 12, 2025, Pagina/e 864, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines12080864

Matrix M Adjuvanted H5N1 Vaccine Elicits Broadly Neutralizing Antibodies and Neuraminidase Inhibiting Antibodies in Humans That Correlate With In Vivo Protection

Autori: Fan Zhou, Lena Hansen, Gabriel Pedersen, Gunnveig Grødeland, Rebecca Cox
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, Pagina/e 747774, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2021.747774

Impact of ageing on homologous and human-coronavirus-reactive antibodies after SARS-CoV-2 vaccination or infection

Autori: Fan Zhou, Juha Vahokoski, null null, Siri Øyen, Marianne Sævik, Hanne Høyland, Helene H. Sandnes, Anders Madsen, Karl A. Brokstad, Kristin G. I. Mohn, Camilla Tøndel, Nina Langeland, Rebecca J. Co
Pubblicato in: npj Vaccines, Numero 9, 2024, Pagina/e 817, ISSN 2059-0105
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41541-024-00817-z

SARS-CoV-2 infection induces long-lived B and T-cell responses up to 15 months post-infection, irrespective of disease severity

Autori: Kristin G.-I. Mohn, Geir Bredholt, Therese Bredholt Onyango, Karl A. Brokstad, Fan Zhou, Jan Cato Holter, Kristian Tonby, Anne Ma Dyrhol-Riise, Rebecca Jane Cox
Pubblicato in: Journal of Infection, Numero 87, 2025, Pagina/e 346-349, ISSN 0163-4453
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2023.05.023

A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern

Autori: Nina Urke Ertesvåg, Julie Xiao, Fan Zhou, Sonja Ljostveit, Helene Sandnes, Sarah Lartey, Marianne Sævik, Lena Hansen, Anders Madsen, Kristin G. I. Mohn, Elisabeth Fjelltveit, Jan Stefan Olofsson, Ti
Pubblicato in: Communications Medicine, Numero 2, 2022, Pagina/e 91, ISSN 2730-664X
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s43856-022-00091-x

Vaccination prevents severe COVID-19 outcome in patients with neutralizing type 1 interferon autoantibodies

Autori: Anette S.B. Wolff, Lena Hansen, Marianne Aa. Grytaas, Bergithe E. Oftedal, Lars Breivik, Fan Zhou, Karl Ove Hufthammer, Thea Sjøgren, Jan Stefan Olofsson, Mai Chi Trieu, Anthony Meager, Anders P. Jø
Pubblicato in: iScience, Numero 26, 2024, Pagina/e 107084, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/j.isci.2023.107084

Symptom Burden and Immune Dynamics 6 to 18 Months Following Mild Severe Acute Respiratory Syndrome Coronavirus 2 Infection (SARS-CoV-2): A Case-control Study

Autori: Elisabeth B Fjelltveit, Bjørn Blomberg, Kanika Kuwelker, Fan Zhou, Therese B Onyango, Karl A Brokstad, Rebecca Elyanow, Ian M Kaplan, Camilla Tøndel, Kristin G I Mohn, Türküler Özgümüş, Rebecc
Pubblicato in: Clinical Infectious Diseases, Numero 76, 2023, Pagina/e e60-e70, ISSN 1058-4838
Editore: University of Chicago Press
DOI: 10.1093/cid/ciac655

Next Generation Influenza Vaccines: Looking into theCrystal Ball

Autori: Carlos Alberto Guzmán
Pubblicato in: Vaccines, 2020, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8030464

Risk assessment and antibody responses to SARS-CoV-2 in healthcare workers

Autori: Amit Bansal, Mai-Chi Trieu, Kristin G. I. Mohn, Anders Madsen, Jan Stefan Olofsson, Helene Heitmann Sandnes, Marianne Sævik, Hanne Søyland, Lena Hansen, Therese Bredholt Onyango, Camilla Tøndel, Ka
Pubblicato in: Frontiers in Public Health, Numero 11, 2023, Pagina/e 1164326, ISSN 2296-2565
Editore: Frontiers Media SA
DOI: 10.3389/fpubh.2023.1164326

Symptom trajectories of post-COVID sequelae in patients with acute Delta or Omicron infection in Bergen, Norway

Autori: Arild Iversen, Bjørn Blomberg, Kjell Haug, Bård Kittang, Türküler Özgümüs, Rebecca Jane Cox, Nina Langeland
Pubblicato in: Frontiers in Public Health, Numero 12, 2024, Pagina/e 1320059, ISSN 2296-2565
Editore: Frontiers Media SA
DOI: 10.3389/fpubh.2024.1320059

Perceived infection risk, infection exposure, and compliance to infection control measures among the first COVID-19 patients in Norway

Autori: Bjørn Sætrevik, Rebecca J. Cox, Dagrun W. Linchausen, Sebastian B. Bjørkheim
Pubblicato in: Scandinavian Journal of Public Health, Numero 53, 2026, Pagina/e 517-524, ISSN 1403-4948
Editore: SAGE Publications
DOI: 10.1177/14034948251315341

SARS-CoV-2 specific immune responses in overweight and obese COVID-19 patients

Autori: Therese Bredholt Onyango, Fan Zhou, Geir Bredholt, Karl A. Brokstad, Sarah Lartey, Kristin G.-I. Mohn, Türküler Özgümüs, Bård Reiakvam Kittang, Dagrun Waag Linchausen, Shahin Shafiani, Rebecca E
Pubblicato in: Frontiers in Immunology, Numero 14, 2023, Pagina/e 1287388, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2023.1287388

Three Doses of Sars-Cov-2 Mrna Vaccine in Older Adults Result in Similar Antibody Responses But Reduced Cellular Cytokine Responses Relative to Younger Adults

Autori: Geir Bredholt, Marianne Sævik, Hanne Søyland, Thor Ueland, Fan Zhou, Rishi Pathirana, Anders Madsen, Juha Vahokoski, Sarah Lartey Jalloh, Bente Halvorsen, Tuva Børresdatter Dahl, Mai Chi T. Trieu,
Pubblicato in: Vaccine: X, Numero 20, 2024, Pagina/e 100564, ISSN 2590-1362
Editore: Elsevier BV
DOI: 10.2139/ssrn.4915330

Durable T-cellular and humoral responses in SARS-CoV-2 hospitalized and community patients

Autori: Kristin G.-I. Mohn, Geir Bredholt, Fan Zhou, Anders Madsen, Therese B. Onyango, Elisabeth B. Fjelltveit, Sarah L. Jalloh, Karl A. Brokstad, Diego Cantoni, Martin Mayora-Neto, Nigel Temperton, Nina Lan
Pubblicato in: PLOS ONE, Numero 17, 2022, Pagina/e e0261979, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0261979

Point-of-Care Influenza Testing Impacts Clinical Decision, Patient Flow, and Length of Stay in Hospitalized Adults

Autori: Elisabeth B Fjelltveit, Rebecca J Cox, Jørgen Østensjø, Bjørn Blomberg, Marit H Ebbesen, Nina Langeland, Kristin G I Mohn
Pubblicato in: The Journal of Infectious Diseases, Numero 226, 2022, Pagina/e 97-108, ISSN 0022-1899
Editore: University of Chicago Press
DOI: 10.1093/infdis/jiaa690

Safety, Immunogenicity, Efficacy and Effectiveness of Inactivated Influenza Vaccines in Healthy Pregnant Women and Children Under 5 Years: An Evidence-Based Clinical Review

Autori: Amit Bansal, Mai-Chi Trieu, Kristin G. I. Mohn, Rebecca Jane Cox
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, Pagina/e 744774, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2021.744774

SARS-CoV-2 infection rates and associated risk factors in healthcare workers: systematic review and meta-analysis

Autori: Amit Bansal, Mai-Chi Trieu, Emily M. Eriksson, Fan Zhou, Jodie McVernon, Karl Albert Brokstad, Rebecca Jane Cox
Pubblicato in: Scientific Reports, Numero 15, 2025, Pagina/e 4705, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-025-89472-5

Durable immune responses after BNT162b2 vaccination in home-dwelling old adults

Autori: Lena Hansen, Karl Albert Brokstad, Amit Bansal, Fan Zhou, Geir Bredholt, Therese Bredholt Onyango, Helene Heitmann Sandnes, Rebecca Elyanow, Anders Madsen, Mai-Chi Trieu, Marianne Sævik, Hanne Søyla
Pubblicato in: Vaccine: X, Numero 13, 2025, Pagina/e 100262, ISSN 2590-1362
Editore: Elsevier BV
DOI: 10.1016/j.jvacx.2023.100262

Multivalent next generation influenza virus vaccines protect against seasonal and pre-pandemic viruses

Autori: Naoko Uno, Ted M. Ross
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-51024-0

Targeted barcoding of variable antibody domains and individual transcriptomes of the human B-cell repertoire using Link-Seq

Autori: Hongxing Hu, Fan Zhou, Xiaoli Ma, Karl Albert Brokstad, Leonie Kolmar, Charles Girardot, Vladimir Benes, Rebecca J Cox, Christoph A Merten
Pubblicato in: PNAS Nexus, Numero 4, 2025, Pagina/e 6, ISSN 2752-6542
Editore: Oxford University Press (OUP)
DOI: 10.1093/pnasnexus/pgaf006

Long COVID in a prospective cohort of home-isolated patients

Autori: Bjørn Blomberg, Kristin Greve-Isdahl Mohn, Karl Albert Brokstad, Fan Zhou, Dagrun Waag Linchausen, Bent-Are Hansen, Sarah Lartey, Therese Bredholt Onyango, Kanika Kuwelker, Marianne Sævik, Hauke Bar
Pubblicato in: Nature Medicine, Numero 27, 2021, Pagina/e 1607-1613, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-021-01433-3

Not just antibodies: B cells and T cells mediate immunity to COVID-19

Autori: Rebecca J. Cox, Karl A. Brokstad
Pubblicato in: Nature Reviews Immunology, Numero 20, 2021, Pagina/e 581-582, ISSN 1474-1733
Editore: Nature Publishing Group
DOI: 10.1038/s41577-020-00436-4

Prospects and Challenges in the Development of Universal Influenza Vaccines

Autori: Anders Madsen, Rebecca Jane Cox
Pubblicato in: Vaccines, Numero 8, 2025, Pagina/e 361, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8030361

Markers of T cell activation and exhaustion in plasma are associated with persistent symptoms up to 18 months following mild SARS-CoV-2 infection

Autori: Thor Ueland, Rebecca Jane Cox, Annika E. Michelsen, Elisabeth Berg Fjelltveit, Kari Otterdal, Tuva Dahl, Fan Zhou, Rebecca Elyanow, Pål Aukrust, Bjørn Blomberg, Bente E. Halvorsen, Nina Langeland
Pubblicato in: Frontiers in Immunology, Numero 16, 2025, Pagina/e 1578208, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1578208