Within Moore4Medical the following demonstrators have been realized:
1. Implantable devices – a platform for ultrasound power transfer
The ultrasound power transfer system has been demonstrated in an implant that will monitor bone healing. The implant is part of a bone plate that is surgically attached to the bone. Deformation of the plate yields important information about the healing process. The implant uses biocompatible optimized MEMS ultrasound transducers to convert the acoustic pressure to electric energy. The system includes focused ultrasound to deliver the power, and power management ASICs. Finally, ultrasound power transfer was benchmarked against inductive power transfer.
2. Organ on Chip – a smart well plate platform
Using the smart well plate platform three demonstrator groups have been realized:
• The versatility of the smart well plate platform was demonstrated with a perfused MEA array, an organoid OoC and a skin-on-chip model;
• The advanced electrophysiology platform was demonstrated with a cardiotoxicity assay;
• The smart well plate lid was demonstrated with a multi-spheroid assay.
3. Drug adherence – intelligent drug delivery
A pen-based smart drug delivery demonstrator has been realized. The demonstrator is based on the drug delivery platform and contains a micropump, driving electronics, wireless communication, a drug reservoir, and embedded sensors. The drug will be administered through a needle for subcutaneous delivery. A smartphone app was developed for drug dose control and data feedback.
4. Next-generation ultrasound – Smart ultrasound
In this work package, adaptable ultrasound front ends have been developed. Combined with deep-learning algorithms, these create closed-loop ultrasound diagnostic systems that fully utilize the advantages of affordable 3D MEMS ultrasound platform technology. At transducer level, 3D MEMS ultrasound platform integration and industrialization is brought to the next level.
5. Towards X-ray free surgery – Advanced optical tracking
In this work package, two demonstrators were realized. In the first place, a backloadable optical shape sensing (OSS) system was demonstrated that is compatible with clinical practice (e.g. sterility requirements). The backloadable OSS system will truly make OSS a universal and open platform. Secondly, the optical instrument tracking system was demonstrated.
6. Continuous monitoring – A bed monitoring platform
The bed monitoring platform developed in Moore4Medical comprises an AI-based platform consisting of an array of sensing devices that jointly gather data from the same patient, and that make use of limited resources such as power. Next to the first use-case, namely the detection of atrial fibrillation, in another use-case the detection of sleeping disorders has been investigated. In addition, a smart, open E2E security and privacy platform has been demonstrated.
Realizing these demonstrators will be instrumental in the development, introduction, and acceptance of open technology platforms for emerging medical devices and these will:
• Expand Europe’s leadership as innovator in medical device technology
• Create new opportunities to increase the competitiveness of the ECS industry
• Help manage the increasing cost of healthcare.
