Structural biology of chromatin transcription

Project Information

CHROMATRANS

Grant agreement ID: 882357

DOI

10.3030/882357

Project terminated on 30 June 2023

EC signature date 12 May 2020

Start date 1 July 2020

End date 30 June 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 017 500,00

EU contribution

€ 2 017 500,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (15)

Yeast PIC-mediator structure with RNA polymerase II C-terminal domain

Author(s): Sandra Schilbach, Haibo Wang, Christian Dienemann, Patrick Cramer
Published in: Proceedings of the National Academy of Sciences of the United States of America., Issue 120(15), 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2220542120

The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II.

Author(s): Sara Osman; Eusra Mohammad; Michael Lidschreiber; Alexandra Stuetzer; Fanni Laura Bazsó; Fanni Laura Bazsó; Kerstin C. Maier; Henning Urlaub; Henning Urlaub; Patrick Cramer
Published in: Journal of Biological Chemistry, Issue 296: 100734, 2021, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100734

Structures of transcription preinitiation complex engaged with the +1 nucleosome

Author(s): Haibo Wang, Sandra Schilbach, Momchil Ninov, Henning Urlaub, Patrick Cramer
Published in: Nature structural & molecular biology., 2022, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-022-00865-w

Structure of a backtracked hexasomal intermediate of nucleosome transcription

Author(s): Lucas Farnung, Moritz Ochmann, Gaurika Garg, Seychelle M Vos, Patrick Cramer
Published in: Molecular cell, Issue 82(17), 2022, Page(s) 3126-3134, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2022.06.027

Structural basis of nucleosome transcription mediated by Chd1 and FACT

Author(s): Lucas Farnung, Moritz Ochmann, Maik Engeholm, Patrick Cramer
Published in: Nature structural & molecular biology, Issue 28(4), 2021, Page(s) 382-387, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-021-00578-6

Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II

Author(s): Srinivasan Rengachari, Sandra Schilbach, Thangavelu Kaliyappan, Jerome Gouge, Kristina Zumer, Juliane Schwarz, Henning Urlaub, Christian Dienemann, Alessandro Vannini, Patrick Cramer
Published in: Nature structural & molecular biology., Issue 29(12), 2022, Page(s) 1159-1169, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-022-00857-w

Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells

Author(s): Le Xiong, Erik A Tolen, Jinmi Choi, Sergiy Velychko, Livia Caizzi, Taras Velychko, Kenjiro Adachi, Caitlin M MacCarthy, Michael Lidschreiber, Patrick Cramer, Hans R Schöler
Published in: eLife., Issue 11, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.71533

Structure of an inactive RNA polymerase II dimer

Author(s): Shintaro Aibara, Christian Dienemann, Patrick Cramer
Published in: Nucleic Acids Research, Issue 49(18), 2021, Page(s) 10747–10755, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkab783

Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2

Author(s): Isaac Fianu, Christian Dienemann, Shintaro Aibara, Sandra Schilbach, Patrick Cramer
Published in: Communications biology, Issue 4: 606, 2021, ISSN 2399-3642
Publisher: Nature Publishing Group UK
DOI: 10.1038/s42003-021-02088-z

Transcription activation depends on the length of the RNA polymerase II C‐terminal domain

Author(s): Anna Sawicka, Gabriel Villamil, Michael Lidschreiber, Xavier Darzacq, Claire Dugast‐Darzacq, Björn Schwalb, Patrick Cramer
Published in: The EMBO journal, Issue 40(9), 2021, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2020107015

Structural basis of RNA processing by human mitochondrial RNase P

Author(s): Arjun Bhatta, Christian Dienemann, Patrick Cramer, Hauke S. Hillen
Published in: Nature structural & molecular biology, Issue 28(9), 2021, Page(s) 713-723, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-021-00637-y

Structures and implications of TBP–nucleosome complexes

Author(s): Haibo Wang, Le Xiong, Patrick Cramer
Published in: Proceedings of the National Academy of Sciences of the United States of America, Issue 118(30), 2021, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2108859118

Structural basis of human transcription–DNA repair coupling

Author(s): Goran Kokic, Felix R. Wagner, Aleksandar Chernev, Henning Urlaub, Patrick Cramer
Published in: Nature, Issue 598(7880), 2021, Page(s) 368-372, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03906-4

The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3′-UTRs of yeast mitochondrial mRNAs

Author(s): Hauke S. Hillen, Dmitriy A. Markov, Ireneusz D. Wojtas, Katharina B. Hofmann, Michael Lidschreiber, Andrew T. Cowan, Julia L. Jones, Dmitry Temiakov, Patrick Cramer, Michael Anikin
Published in: Proceedings of the National Academy of Sciences of the United States of America, Issue 118(15), 2021, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2009329118

Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory

Author(s): Marco Dombrowski, Maik Engeholm, Christian Dienemann, Svetlana Dodonova, Patrick Cramer
Published in: Nature Structural and Molecular Biology, Issue 29(5), 2022, Page(s) 493-501, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-022-00768-w