Structural biology of chromatin transcription

Informazioni relative al progetto

CHROMATRANS

ID dell’accordo di sovvenzione: 882357

DOI 10.3030/882357

Progetto concluso il 30 Giugno 2023

Data della firma CE 12 Maggio 2020

Data di avvio 1 Luglio 2020

Data di completamento 30 Giugno 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 017 500,00

Contributo UE € 2 017 500,00

Coordinato da

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

Pubblicazioni

Peer reviewed articles (15)

Yeast PIC-mediator structure with RNA polymerase II C-terminal domain

Autori: Sandra Schilbach, Haibo Wang, Christian Dienemann, Patrick Cramer
Pubblicato in: Proceedings of the National Academy of Sciences of the United States of America., Numero 120(15), 2023, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2220542120

The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II.

Autori: Sara Osman; Eusra Mohammad; Michael Lidschreiber; Alexandra Stuetzer; Fanni Laura Bazsó; Fanni Laura Bazsó; Kerstin C. Maier; Henning Urlaub; Henning Urlaub; Patrick Cramer
Pubblicato in: Journal of Biological Chemistry, Numero 296: 100734, 2021, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100734

Structures of transcription preinitiation complex engaged with the +1 nucleosome

Autori: Haibo Wang, Sandra Schilbach, Momchil Ninov, Henning Urlaub, Patrick Cramer
Pubblicato in: Nature structural & molecular biology., 2022, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-022-00865-w

Structure of a backtracked hexasomal intermediate of nucleosome transcription

Autori: Lucas Farnung, Moritz Ochmann, Gaurika Garg, Seychelle M Vos, Patrick Cramer
Pubblicato in: Molecular cell, Numero 82(17), 2022, Pagina/e 3126-3134, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2022.06.027

Structural basis of nucleosome transcription mediated by Chd1 and FACT

Autori: Lucas Farnung, Moritz Ochmann, Maik Engeholm, Patrick Cramer
Pubblicato in: Nature structural & molecular biology, Numero 28(4), 2021, Pagina/e 382-387, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-021-00578-6

Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II

Autori: Srinivasan Rengachari, Sandra Schilbach, Thangavelu Kaliyappan, Jerome Gouge, Kristina Zumer, Juliane Schwarz, Henning Urlaub, Christian Dienemann, Alessandro Vannini, Patrick Cramer
Pubblicato in: Nature structural & molecular biology., Numero 29(12), 2022, Pagina/e 1159-1169, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-022-00857-w

Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells

Autori: Le Xiong, Erik A Tolen, Jinmi Choi, Sergiy Velychko, Livia Caizzi, Taras Velychko, Kenjiro Adachi, Caitlin M MacCarthy, Michael Lidschreiber, Patrick Cramer, Hans R Schöler
Pubblicato in: eLife., Numero 11, 2022, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.71533

Structure of an inactive RNA polymerase II dimer

Autori: Shintaro Aibara, Christian Dienemann, Patrick Cramer
Pubblicato in: Nucleic Acids Research, Numero 49(18), 2021, Pagina/e 10747–10755, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkab783

Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2

Autori: Isaac Fianu, Christian Dienemann, Shintaro Aibara, Sandra Schilbach, Patrick Cramer
Pubblicato in: Communications biology, Numero 4: 606, 2021, ISSN 2399-3642
Editore: Nature Publishing Group UK
DOI: 10.1038/s42003-021-02088-z

Transcription activation depends on the length of the RNA polymerase II C‐terminal domain

Autori: Anna Sawicka, Gabriel Villamil, Michael Lidschreiber, Xavier Darzacq, Claire Dugast‐Darzacq, Björn Schwalb, Patrick Cramer
Pubblicato in: The EMBO journal, Numero 40(9), 2021, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2020107015

Structural basis of RNA processing by human mitochondrial RNase P

Autori: Arjun Bhatta, Christian Dienemann, Patrick Cramer, Hauke S. Hillen
Pubblicato in: Nature structural & molecular biology, Numero 28(9), 2021, Pagina/e 713-723, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-021-00637-y

Structures and implications of TBP–nucleosome complexes

Autori: Haibo Wang, Le Xiong, Patrick Cramer
Pubblicato in: Proceedings of the National Academy of Sciences of the United States of America, Numero 118(30), 2021, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2108859118

Structural basis of human transcription–DNA repair coupling

Autori: Goran Kokic, Felix R. Wagner, Aleksandar Chernev, Henning Urlaub, Patrick Cramer
Pubblicato in: Nature, Numero 598(7880), 2021, Pagina/e 368-372, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03906-4

The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3′-UTRs of yeast mitochondrial mRNAs

Autori: Hauke S. Hillen, Dmitriy A. Markov, Ireneusz D. Wojtas, Katharina B. Hofmann, Michael Lidschreiber, Andrew T. Cowan, Julia L. Jones, Dmitry Temiakov, Patrick Cramer, Michael Anikin
Pubblicato in: Proceedings of the National Academy of Sciences of the United States of America, Numero 118(15), 2021, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2009329118

Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory

Autori: Marco Dombrowski, Maik Engeholm, Christian Dienemann, Svetlana Dodonova, Patrick Cramer
Pubblicato in: Nature Structural and Molecular Biology, Numero 29(5), 2022, Pagina/e 493-501, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-022-00768-w