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Targeting Shelterin Proteins in Cancer

Project description

Telomerase-protecting shelterings as a novel anticancer target

Telomeres are structures at the chromosome ends critical for genome stability. Shelterin, or telosome, is a protein complex protecting telomeres in eukaryotic cells from DNA repair mechanisms and regulating telomerase activity. Recent studies show that components of the shelterin complex mutated in cancer. The EU-funded SHELTERINS project attempts to establish a comprehensive strategy and set of tools to conduct a fundamental investigation on the role of shelterin in cancer. The project's researchers were first in describing shelterin mutations in cancer and presented the idea of targeting shelterin as an anticancer strategy to induce length-independent telomere damage. In the current proposal, they will use mouse models, developing an approach to block the ability of cancer cells to divide indefinitely, effectively impairing cancer growth.

Call for proposal

ERC-2019-ADG
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Funding Scheme

ERC-ADG - Advanced Grant

Host institution

FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Spain
Activity type
Research Organisations
EU contribution
€ 2 495 466

Beneficiaries (1)

FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
Spain
EU contribution
€ 2 495 466
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Activity type
Research Organisations