Project description
Revisiting tumour immunosurveillance under a different prism
Tumour immunosurveillance remains a big enigma in immunology. Evidence indicates that the activation of T cells by tumour antigens is context-dependent, and experimental models used to study the phenomenon do not always recapitulate the in vivo situation. To address this problem, the EU-funded NeoTs project will express proven or predicted neoantigens in mouse models under resting conditions to determine the nature of antigens capable of inducing functional T cells as well as the long term fate of the latter. Results will help clarify whether the best target antigens are retained or lost before cancer becomes clinically apparent, a question of high clinical relevance.
Fields of science
Programme(s)
Topic(s)
Funding Scheme
ERC-ADG - Advanced Grant
Host institution
13125 Berlin
Germany
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Beneficiaries (1)
13125 Berlin
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