Project description
Revisiting tumour immunosurveillance under a different prism
Tumour immunosurveillance remains a big enigma in immunology. Evidence indicates that the activation of T cells by tumour antigens is context-dependent, and experimental models used to study the phenomenon do not always recapitulate the in vivo situation. To address this problem, the EU-funded NeoTs project will express proven or predicted neoantigens in mouse models under resting conditions to determine the nature of antigens capable of inducing functional T cells as well as the long term fate of the latter. Results will help clarify whether the best target antigens are retained or lost before cancer becomes clinically apparent, a question of high clinical relevance.
Fields of science
Programme(s)
Topic(s)
Funding Scheme
ERC-ADG - Advanced Grant
Host institution
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
Net EU contribution
€ 2 499 573,75
Address
Robert Rossle Strasse 10
13125 Berlin
Germany
13125 Berlin
Germany
See on map
Region
Berlin Berlin Berlin
Activity type
Research Organisations
Other funding
€ 0,00
Beneficiaries (1)
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
Germany
Net EU contribution
€ 2 499 573,75
Address
Robert Rossle Strasse 10
13125 Berlin
13125 Berlin
See on map
Region
Berlin Berlin Berlin
Activity type
Research Organisations
Other funding
€ 0,00