Multiple Designer Organelles for Expanded Eukaryotic life

Project Information

MultiOrganelleDesign

Grant agreement ID: 883687

DOI

10.3030/883687

EC signature date 29 May 2020

Start date 1 January 2022

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 068,00

EU contribution

€ 2 499 068,00

Coordinated by

JOHANNES GUTENBERG-UNIVERSITAT MAINZ
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Non-peer reviewed articles (2)

Intrinsic disorder: A term to define the specific physicochemical characteristic of protein conformational heterogeneity

Author(s): Edward A. Lemke, M. Madan Babu, Richard W. Kriwacki, Tanja Mittag, Rohit V. Pappu, Peter E. Wright, Julie D. Forman-Kay
Published in: Molecular Cell, Issue 84, 2024, Page(s) 1188-1190, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2024.02.024

Cracking the Code: Reprogramming the Genetic Script in Prokaryotes and Eukaryotes to Harness the Power of Noncanonical Amino Acids

Author(s): Cosimo Jann, Sabrina Giofré, Rajanya Bhattacharjee, Edward A. Lemke
Published in: Chemical Reviews, 2024, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.3c00878

Peer reviewed articles (7)

Tuning the Functionality of Designer Translating Organelles with Orthogonal tRNA Synthetase/tRNA Pairs

Author(s): Mikhail E. Sushkin, Marius Jung, Edward A. Lemke
Published in: Journal of Molecular Biology, 2024, Page(s) 168728, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2024.168728

Bioorthogonal click labeling of an amber-free HIV-1 provirus for in-virus single molecule imaging

Author(s): Yuanyun Ao, Jonathan R. Grover, Levi Gifford, Yang Han, Guohua Zhong, Revansiddha Katte, Wenwei Li, Rajanya Bhattacharjee, Baoshan Zhang, Stephanie Sauve, Wenyi Qin, Dibya Ghimire, Md Anzarul Haque, James Arthos, Mahmoud Moradi, Walther Mothes, Edward A. Lemke, Peter D. Kwong, Gregory B. Melikyan, Maolin Lu
Published in: Cell Chemical Biology, Issue 31, 2024, Page(s) 487-501.e7, ISSN 2451-9456
Publisher: Cell Press
DOI: 10.1016/j.chembiol.2023.12.017

Selective RNA pseudouridinylation in situ by circular gRNAs in designer organelles

Author(s): Lukas Schartel, Cosimo Jann, Anna Wierczeiko, Tamer Butto, Stefan Mündnich, Virginie Marchand, Yuri Motorin, Mark Helm, Susanne Gerber, Edward A. Lemke
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-53403-1

Synthesis, Biochemical Characterization, and Genetic Encoding of a 1,2,4-Triazole Amino Acid as an Acetyllysine Mimic for Bromodomains of the BET Family

Author(s): Dr. Sören Kirchgäßner, Dr. Michael B. Braun, Natascha Bartlick, Dr. Cengiz Koç, Dr. Christopher D. Reinkemeier, Prof. Dr. Edward A. Lemke, Prof. Dr. Thilo Stehle, Prof. Dr. Dirk Schwarzer
Published in: Angewandte Chemie International Edition, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202215460

Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins

Author(s): Ganesh Agam, Christian Gebhardt, Milana Popara, Rebecca Mächtel, Julian Folz, Benjamin Ambrose, Neharika Chamachi, Sang Yoon Chung, Timothy D. Craggs, Marijn de Boer, Dina Grohmann, Taekjip Ha, Andreas Hartmann, Jelle Hendrix, Verena Hirschfeld, Christian G. Hübner, Thorsten Hugel, Dominik Kammerer, Hyun-Seo Kang, Achillefs N. Kapanidis, Georg Krainer, Kevin Kramm, Edward A. Lemke, Eitan Lerner,
Published in: Nature Methods, 2023, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-023-01807-0

Visualizing the disordered nuclear transport machinery in situ

Author(s): Miao Yu, Maziar Heidari, Sofya Mikhaleva, Piau Siong Tan, Sara Mingu, Hao Ruan, Christopher D. Reinkemeier, Agnieszka Obarska-Kosinska, Marc Siggel, Martin Beck, Gerhard Hummer, Edward A. Lemke
Published in: Nature, 2023, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-05990-0

Potential vs Challenges of Expanding the Protein Universe With Genetic Code Expansion in Eukaryotic Cells

Author(s): Rajanya Bhattacharjee, Edward A. Lemke
Published in: Journal of Molecular Biology, Issue 436, 2024, Page(s) 168807, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2024.168807

Book chapters (1)

Synthetic Organelles for Multiple mRNA Selective Genetic Code Expansions in Eukaryotes

Author(s): Christopher D. Reinkemeier, Edward A. Lemke
Published in: Phase-Separated Biomolecular Condensates, 2022, Page(s) 341–369, ISBN 978-1-0716-2663-4
Publisher: Humana
DOI: 10.1007/978-1-0716-2663-4_17