Next Generation Gene Therapy for the Treatment of Chronic Myocardial Ischemia and Heart Failure

Project Information

HeartGenes

Grant agreement ID: 884382

DOI 10.3030/884382

EC signature date 9 June 2020

Start date 1 May 2021

End date 30 April 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

ITA-SUOMEN YLIOPISTO
Finland

Publications

Peer reviewed articles (10)

Large Animal Model for Evaluating the Efficacy of the Gene Therapy in Ischemic Heart

Author(s): Korpela H., Siimes S., Ylä-Herttuala S.
Published in: JoVE Journal of Visualized Experiments, 2021, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/62833

Adenoviral VEGF-B186R127S gene transfer induces angiogenesis and improves perfusion in ischemic heart

Author(s): Korpela Henna, Hätinen Olli-Pekka, Nieminen Tiina, Mallick Rahul, Toivanen Pyry, Airaksinen Jonna, Valli Kaisa, Hakulinen Mikko, Poutiainen Pekka, Nurro Jussi, Ylä-Herttuala Seppo
Published in: iScience, 2021, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2021.103533

Characterization of a new IN-I-PpoI fusion protein and a homology-arm containing transgene cassette that improve transgene expression persistence and 28S rRNA gene-targeted insertion of lentiviral vectors

Author(s): Alisa Nousiainen; Diana Schenkwein; Seppo Ylä-Herttuala
Published in: PlosOne, Issue 1, 2023, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0280894

Capillary Dynamics Regulate Post-Ischemic Muscle Damage and Regeneration in Experimental Hindlimb Ischemia

Author(s): Galina Wirth; Greta Juusola; Santeri Tarvainen; Johanna P. Laakkonen; Petra Korpisalo; Seppo Ylä-Herttuala
Published in: Cells; Volume 12; Issue 16; Pages: 2060, Issue 3, 2023, ISSN 2073-4409
Publisher: Basel MDPI AG
DOI: 10.3390/cells12162060

AAV2-VEGF-B gene therapy failed to induce angiogenesis in ischemic porcine myocardium due to inflammatory responses

Author(s): Henna Korpela, Jaakko Lampela, Jonna Airaksinen, Niko Järveläinen, Satu Siimes, Kaisa Valli, Tiina Nieminen, Minttu Turunen, Maria Grönman, Antti Saraste, Juhani Knuuti, Mikko Hakulinen, Pekka Poutiainen, Vesa Kärjä, Jussi Nurro, and Seppo Ylä-Herttuala
Published in: Gene Therapy, 2022, ISSN 0969-7128
Publisher: Nature Publishing Group
DOI: 10.1038/s41434-022-00322-9

Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity

Author(s): Kettunen S, Ruotsalainen AK, Örd T, Suoranta T, Heikkilä J, Kaikkonen MU, Laham-Karam N, Ylä-Herttuala S
Published in: Frontiers in Cardiovascular Medicine, 2023, ISSN 2297-055X
Publisher: Frontiers Media
DOI: 10.3389/fcvm.2023.1113890

Role of non-coding RNAs in physiological and pathological angiogenesis

Author(s): Nihay Laham-Karam; Isidore Mushimiyimana; Krista Hokkanen; Seppo Ylä-Herttuala
Published in: Current Opinion in Physiology, Issue 1, 2023, ISSN 2468-8673
Publisher: Elsevier
DOI: 10.1016/j.cophys.2023.100690

Critical limb-threatening ischaemia and microvascular transformation: clinical implications

Author(s): Santeri Tarvainen; Galina Wirth; Greta Juusola; Olli Hautero; Kari Kalliokoski; Tanja Sjöros; Veikko Nikulainen; Jouni Taavitsainen; Jarkko Hytönen; Crister Frimodig; Krista Happonen; Tuomas Selander; Tomi Laitinen; Harri H Hakovirta; Juhani Knuuti; Nihay Laham-Karam; Juha Hartikainen; Kimmo Mäkinen; Seppo Ylä-Herttuala; Petra Korpisalo
Published in: European Heart Journal - Quality of care and clinical outcomes, Issue 5, 2023, ISSN 2058-1742
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehad562

Novel Designed Proteolytically Resistant VEGF-B186R127S Promotes Angiogenesis in Mouse Heart byRecruiting Endothelial Progenitor Cells

Author(s): Rahul Mallick, , Erika Gurzeler, Pyry I. Toivanen, Tiina Nieminen and Seppo Ylä-Herttuala
Published in: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2022.907538

Strategies to improve safety profile of AAV vectors

Author(s): Tuisku Suoranta, Nihay Laham-Karam and Seppo Ylä-Herttuala
Published in: Frontiers in Molecular Medicine, 2022, ISSN 2674-0095
Publisher: Frontiers Media SA
DOI: 10.3389/fmmed.2022.1054069

Non-peer reviewed articles (1)

RNA interference-based therapies for the control of atherosclerosis risk factors

Author(s): Sanna Kettunen, Anna-Kaisa Ruotsalainen, Seppo Ylä-Herttuala
Published in: Current Opinion in Cardiology, 2022, ISSN 0268-4705
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/hco.0000000000000972