Next Generation Gene Therapy for the Treatment of Chronic Myocardial Ischemia and Heart Failure

Publikacje

Large Animal Model for Evaluating the Efficacy of the Gene Therapy in Ischemic Heart

Autorzy: Korpela H., Siimes S., Ylä-Herttuala S.
Opublikowane w: JoVE Journal of Visualized Experiments, 2021, ISSN 1940-087X
Wydawca: MYJoVE Corporation
DOI: 10.3791/62833

Adenoviral VEGF-B186R127S gene transfer induces angiogenesis and improves perfusion in ischemic heart

Autorzy: Korpela Henna, Hätinen Olli-Pekka, Nieminen Tiina, Mallick Rahul, Toivanen Pyry, Airaksinen Jonna, Valli Kaisa, Hakulinen Mikko, Poutiainen Pekka, Nurro Jussi, Ylä-Herttuala Seppo
Opublikowane w: iScience, 2021, ISSN 2589-0042
Wydawca: Elsevier
DOI: 10.1016/j.isci.2021.103533

Characterization of a new IN-I-PpoI fusion protein and a homology-arm containing transgene cassette that improve transgene expression persistence and 28S rRNA gene-targeted insertion of lentiviral vectors

Autorzy: Alisa Nousiainen; Diana Schenkwein; Seppo Ylä-Herttuala
Opublikowane w: PlosOne, Numer 1, 2023, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0280894

Capillary Dynamics Regulate Post-Ischemic Muscle Damage and Regeneration in Experimental Hindlimb Ischemia

Autorzy: Galina Wirth; Greta Juusola; Santeri Tarvainen; Johanna P. Laakkonen; Petra Korpisalo; Seppo Ylä-Herttuala
Opublikowane w: Cells; Volume 12; Numer 16; Pages: 2060, Numer 3, 2023, ISSN 2073-4409
Wydawca: Basel MDPI AG
DOI: 10.3390/cells12162060

AAV2-VEGF-B gene therapy failed to induce angiogenesis in ischemic porcine myocardium due to inflammatory responses

Autorzy: Henna Korpela, Jaakko Lampela, Jonna Airaksinen, Niko Järveläinen, Satu Siimes, Kaisa Valli, Tiina Nieminen, Minttu Turunen, Maria Grönman, Antti Saraste, Juhani Knuuti, Mikko Hakulinen, Pekka Poutiainen, Vesa Kärjä, Jussi Nurro, and Seppo Ylä-Herttuala
Opublikowane w: Gene Therapy, 2022, ISSN 0969-7128
Wydawca: Nature Publishing Group
DOI: 10.1038/s41434-022-00322-9

Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity

Autorzy: Kettunen S, Ruotsalainen AK, Örd T, Suoranta T, Heikkilä J, Kaikkonen MU, Laham-Karam N, Ylä-Herttuala S
Opublikowane w: Frontiers in Cardiovascular Medicine, 2023, ISSN 2297-055X
Wydawca: Frontiers Media
DOI: 10.3389/fcvm.2023.1113890

Role of non-coding RNAs in physiological and pathological angiogenesis

Autorzy: Nihay Laham-Karam; Isidore Mushimiyimana; Krista Hokkanen; Seppo Ylä-Herttuala
Opublikowane w: Current Opinion in Physiology, Numer 1, 2023, ISSN 2468-8673
Wydawca: Elsevier
DOI: 10.1016/j.cophys.2023.100690

Critical limb-threatening ischaemia and microvascular transformation: clinical implications

Autorzy: Santeri Tarvainen; Galina Wirth; Greta Juusola; Olli Hautero; Kari Kalliokoski; Tanja Sjöros; Veikko Nikulainen; Jouni Taavitsainen; Jarkko Hytönen; Crister Frimodig; Krista Happonen; Tuomas Selander; Tomi Laitinen; Harri H Hakovirta; Juhani Knuuti; Nihay Laham-Karam; Juha Hartikainen; Kimmo Mäkinen; Seppo Ylä-Herttuala; Petra Korpisalo
Opublikowane w: European Heart Journal - Quality of care and clinical outcomes, Numer 5, 2023, ISSN 2058-1742
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehad562

Novel Designed Proteolytically Resistant VEGF-B186R127S Promotes Angiogenesis in Mouse Heart byRecruiting Endothelial Progenitor Cells

Autorzy: Rahul Mallick, , Erika Gurzeler, Pyry I. Toivanen, Tiina Nieminen and Seppo Ylä-Herttuala
Opublikowane w: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2022.907538

Strategies to improve safety profile of AAV vectors

Autorzy: Tuisku Suoranta, Nihay Laham-Karam and Seppo Ylä-Herttuala
Opublikowane w: Frontiers in Molecular Medicine, 2022, ISSN 2674-0095
Wydawca: Frontiers Media SA
DOI: 10.3389/fmmed.2022.1054069

RNA interference-based therapies for the control of atherosclerosis risk factors

Autorzy: Sanna Kettunen, Anna-Kaisa Ruotsalainen, Seppo Ylä-Herttuala
Opublikowane w: Current Opinion in Cardiology, 2022, ISSN 0268-4705
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/hco.0000000000000972

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