Targeting auto-reactive B-cells by vaccination to cure human auto-immune disease

Project Information

Target to B-cure

Grant agreement ID: 884796

DOI

10.3030/884796

EC signature date 19 June 2020

Start date 1 January 2021

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Publications

Peer reviewed articles (17)

IgG Anti–Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross-Sectional Study Encompassing ~1,500 Samples

Author(s): T. Kissel, L. Hafkenscheid, T.J. Wesemael, M. Tamai, S. Kawashiri, A. Kawakami, H.S. El-Gabalawy, D. van Schaardenburg. S. Rantapää-Dahlqvist, M. Wuhrur, A.H.M. van der Helm-van Mil, C.F. Allaart, D. van der Woude, H.U. Scherer, R.E.M. Toes, T.W.J. Huizinga
Published in: Arthritis & Rheumatolgy, 2022, Page(s) 1147-1158, ISSN 2326-5191
Publisher: Danvers, MA American College of Rheumatology
DOI: 10.1002/art.42098

Autoreactive B cells remain active despite clinical disease control in rheumatoid arthritis

Author(s): Sam Neppelenbroek, Nienke J. Blomberg, Arieke S.B. Kampstra, Joost G.K. van der Hem, Tom W.J. Huizinga, René E.M. Toes, Hans U. Scherer
Published in: Journal of Autoimmunity, Issue 149, 2025, Page(s) 103320, ISSN 0896-8411
Publisher: Academic Press
DOI: 10.1016/j.jaut.2024.103320

Evolution of anti-modified protein antibody responses can be driven by consecutive exposure to different post-translational modifications

Author(s): M. Volkov; A. S. B. Kampstra; K. A. van Schie; A. Kawakami; M. Tamai; S. Kawashiri; T. Maeda; T. W. J. Huizinga; R. E. M. Toes; D. van der Woude
Published in: Arthritis Research & Therapy, Issue 3, 2021, ISSN 1478-6362
Publisher: BioMed Central c2003-
DOI: 10.1186/s13075-021-02687-5

Cross-reactivity of anti-modified protein antibodies is also present in predisease and individuals without rheumatoid arthritis

Author(s): S. Reijm, A.S. Brehler, S. Rantapää-Dahlqvist, A. Kawakami, T. Maeda, S. Kawashiri, M. Tamai, D. van der Woude, R.E.M. Toes
Published in: Annals of Rheumatic Diseases, 2022, ISSN 1468-2060
Publisher: BMJ Pub. Group
DOI: 10.1136/annrheumdis-2022-222326

Anti-myeloperoxidase IgM B cells in anti-neutrophil cytoplasmic antibody-associated vasculitis

Author(s): CM Wortel, R. van de Wetering, EM Stork, T. Kissel, S. Reijm, D. van der Woude, KA van Schie, LA Trouw, YKO Teng, A. Rutgers, P. Heeringa, RE Voll, M. Rizzi, N. Venhoff, REM Toes, HU Scherer
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-56786-x

Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load

Author(s): Sanne Reijm; Theresa Kissel; Gerrie Stoeken-Rijsbergen; Linda M. Slot; Corrie M. Wortel; Hugo J. van Dooren; Nivine E. W. Levarht; Arieke S. B. Kampstra; Veerle F. A. M. Derksen; Pleuni Ooijevaar-de Heer; Holger Bang; Jan W. Drijfhout; Leendert A. Trouw; Tom W J Huizinga; Theo Rispens; Hans Scherer; René E. M. Toes
Published in: Arthritis Research and Therapy, Issue 4, 2021, ISSN 1478-6362
Publisher: BioMed Central c2003-
DOI: 10.1186/s13075-021-02609-5

Absence of Epstein-Barr virus DNA in anti-citrullinated protein antibody-expressing B cells of patients with rheumatoid arthritis

Author(s): Kroos, S., Kampstra, A.S.B., Toes, R.E.M. et al
Published in: Arthritis Res Ther, Issue 24, 2022, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-022-02919-2

Genetic predisposition (HLA-SE) is associated with ACPA-IgG variable domain glycosylation in the predisease phase of RA

Author(s): T. Kissel, T.J. van Wesemael, A. Lundquist, H. Kokkonen, A. Kawakami, M. Tamai, D. van Schaardenburg, M. Wuhruer, T.W.J. Huizinga, H.U. Scherer, D. van der Woude, S. Rantapää-Dahlqvist, R.E.M. Toes
Published in: Annals of the Rheumatic Diseases, 2021, Page(s) 141-143, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220841

N-linked Fc glycosylation is not required for IgG-B-cell receptor function in a GC-derived B-cell line

Author(s): Kissel T, Derksen VFAM, Bentlage AEH, Koeleman C, Hafkenscheid L, van der Woude D, Wuhrer M, Vidarsson G, Toes REM
Published in: Nature Communications, Issue 2024 Jan 9;15(1):393, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-44468-5

Autoreactive B cells in rheumatoid arthritis consist of activated CXCR3+ memory B cells and plasmablasts

Author(s): Sanne Reijm, Joanneke C. Kwekkeboom, Nienke J. Blomberg, Jolien Suurmond, Diane van der Woude, Rene E.M. Toes, Hans U. Scherer
Published in: bioRxiv, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.05.19.538699

Antigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritis

Author(s): Eva Maria Stork, Danique M. H. van Rijswijck, Karin A. van Schie, Max Hoek, Theresa Kissel, Hans Ulrich Scherer, Tom W. J. Huizinga, Albert J. R. Heck, Rene E. M. Toes, Albert Bondt
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-47337-x

Autoreactive B cells in extremes of rheumatoid arthritis disease phenotypes

Author(s): Nienke J. Blomberg, Hendy Kristyanto, Marloes Verstappen, Sam Neppelenbroek, Annette H.M. van der Helm-van Mil, René E.M. Toes, Hans Ulrich Scherer
Published in: Annals of the Rheumatic Diseases, Issue 2025 Jun 17:S0003-4967(25)00965-3, 2025, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1016/j.ard.2025.05.006

Increased Phosphorylation of Intracellular Signaling Molecules Indicates Continuous Activation of Human Autoreactive B‐Cells

Author(s): Sanne Kroos, Nienke J. Blomberg, Joanneke C. Kwekkeboom, Rudi W. Hendriks, Odilia B. J. Corneth, René E. M. Toes, Hans U. Scherer
Published in: European Journal of Immunology, Issue 55, 2025, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202451361

Multifunctional, Multivalent PIC Polymer Scaffolds for Targeting Antigen-Specific, Autoreactive B Cells

Author(s): H. Kristyanto, M.D. Holborough-Kerkvliet, L. Lelieveldt, Y. Bartels, R. Hammink, K.A.J. van Schie, R.E.M. Toes, K.M. Bonger, H.U. Scherer
Published in: ACS biomaterials science & engineering, 2022, Page(s) 1486-1493, ISSN 2373-9878
Publisher: American Chemical Society
DOI: 10.1021/acsbiomaterials.1c01395

Acetylated bacterial proteins as potent antigens inducing an anti-modified protein antibody response

Author(s): Mikhail Volkov, Arieke S B Kampstra, Karin A J van Schie, Anouk G van Mourik, Joanneke C Kwekkeboom, Arnoud de Ru, Peter A van Veelen, Tom W J Huizinga, René E M Toes, Diane van der Woude
Published in: RMD Open, Issue 10, 2024, Page(s) e004411, ISSN 2056-5933
Publisher: BMJ
DOI: 10.1136/rmdopen-2024-004411

Addressing the key issue: Antigen-specific targeting of B cells in autoimmune diseases

Author(s): Holborough-Kerkvliet MD, Kroos S, van de Wetering R, Toes REM
Published in: Immunol Lett, Issue 259, 2023, Page(s) 37-45, ISSN 0165-2478
Publisher: Elsevier BV
DOI: 10.1016/j.imlet.2023.05.005

Checkpoints controlling the induction of B cell mediated autoimmunity in human autoimmune diseases

Author(s): S. Reijm, T. Kissel, R.E.M. Toes
Published in: European Journal of Immunology, 2020, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048820

Non-peer reviewed articles (3)

Immune response to post-translationally modified proteins in rheumatoid arthritis: what makes it special?

Author(s): Diane van der Woude, René E M Toes
Published in: Annals of the Rheumatic Diseases, Issue 83, 2025, Page(s) 838-846, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/ard-2023-224103

The Autoantibody response in rheumatoid arthritis; what makes it unique?

Author(s): Rene E.M. Toes
Published in: Seminars in Arthritis and Rheumatism, Issue 72, 2025, Page(s) 152699, ISSN 0049-0172
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semarthrit.2025.152699

Autoantibodies in rheumatoid arthritis – rheumatoid factor, anticitrullinated protein antibodies and beyond

Author(s): Günter Steiner, René E.M. Toes
Published in: Current Opinion in Rheumatology, Issue 36, 2025, Page(s) 217-224, ISSN 1040-8711
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/bor.0000000000001006