Targeting auto-reactive B-cells by vaccination to cure human auto-immune disease

Informazioni relative al progetto

Target to B-cure

ID dell’accordo di sovvenzione: 884796

DOI

10.3030/884796

Data della firma CE 19 Giugno 2020

Data di avvio 1 Gennaio 2021

Data di completamento 31 Dicembre 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 500 000,00

Contributo UE

€ 2 500 000,00

Coordinato da

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

Pubblicazioni

Peer reviewed articles (17)

IgG Anti–Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross-Sectional Study Encompassing ~1,500 Samples

Autori: T. Kissel, L. Hafkenscheid, T.J. Wesemael, M. Tamai, S. Kawashiri, A. Kawakami, H.S. El-Gabalawy, D. van Schaardenburg. S. Rantapää-Dahlqvist, M. Wuhrur, A.H.M. van der Helm-van Mil, C.F. Allaart, D. van der Woude, H.U. Scherer, R.E.M. Toes, T.W.J. Huizinga
Pubblicato in: Arthritis & Rheumatolgy, 2022, Pagina/e 1147-1158, ISSN 2326-5191
Editore: Danvers, MA American College of Rheumatology
DOI: 10.1002/art.42098

Autoreactive B cells remain active despite clinical disease control in rheumatoid arthritis

Autori: Sam Neppelenbroek, Nienke J. Blomberg, Arieke S.B. Kampstra, Joost G.K. van der Hem, Tom W.J. Huizinga, René E.M. Toes, Hans U. Scherer
Pubblicato in: Journal of Autoimmunity, Numero 149, 2025, Pagina/e 103320, ISSN 0896-8411
Editore: Academic Press
DOI: 10.1016/j.jaut.2024.103320

Evolution of anti-modified protein antibody responses can be driven by consecutive exposure to different post-translational modifications

Autori: M. Volkov; A. S. B. Kampstra; K. A. van Schie; A. Kawakami; M. Tamai; S. Kawashiri; T. Maeda; T. W. J. Huizinga; R. E. M. Toes; D. van der Woude
Pubblicato in: Arthritis Research & Therapy, Numero 3, 2021, ISSN 1478-6362
Editore: BioMed Central c2003-
DOI: 10.1186/s13075-021-02687-5

Cross-reactivity of anti-modified protein antibodies is also present in predisease and individuals without rheumatoid arthritis

Autori: S. Reijm, A.S. Brehler, S. Rantapää-Dahlqvist, A. Kawakami, T. Maeda, S. Kawashiri, M. Tamai, D. van der Woude, R.E.M. Toes
Pubblicato in: Annals of Rheumatic Diseases, 2022, ISSN 1468-2060
Editore: BMJ Pub. Group
DOI: 10.1136/annrheumdis-2022-222326

Anti-myeloperoxidase IgM B cells in anti-neutrophil cytoplasmic antibody-associated vasculitis

Autori: CM Wortel, R. van de Wetering, EM Stork, T. Kissel, S. Reijm, D. van der Woude, KA van Schie, LA Trouw, YKO Teng, A. Rutgers, P. Heeringa, RE Voll, M. Rizzi, N. Venhoff, REM Toes, HU Scherer
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-56786-x

Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load

Autori: Sanne Reijm; Theresa Kissel; Gerrie Stoeken-Rijsbergen; Linda M. Slot; Corrie M. Wortel; Hugo J. van Dooren; Nivine E. W. Levarht; Arieke S. B. Kampstra; Veerle F. A. M. Derksen; Pleuni Ooijevaar-de Heer; Holger Bang; Jan W. Drijfhout; Leendert A. Trouw; Tom W J Huizinga; Theo Rispens; Hans Scherer; René E. M. Toes
Pubblicato in: Arthritis Research and Therapy, Numero 4, 2021, ISSN 1478-6362
Editore: BioMed Central c2003-
DOI: 10.1186/s13075-021-02609-5

Absence of Epstein-Barr virus DNA in anti-citrullinated protein antibody-expressing B cells of patients with rheumatoid arthritis

Autori: Kroos, S., Kampstra, A.S.B., Toes, R.E.M. et al
Pubblicato in: Arthritis Res Ther, Numero 24, 2022, ISSN 1478-6362
Editore: BMC
DOI: 10.1186/s13075-022-02919-2

Genetic predisposition (HLA-SE) is associated with ACPA-IgG variable domain glycosylation in the predisease phase of RA

Autori: T. Kissel, T.J. van Wesemael, A. Lundquist, H. Kokkonen, A. Kawakami, M. Tamai, D. van Schaardenburg, M. Wuhruer, T.W.J. Huizinga, H.U. Scherer, D. van der Woude, S. Rantapää-Dahlqvist, R.E.M. Toes
Pubblicato in: Annals of the Rheumatic Diseases, 2021, Pagina/e 141-143, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220841

N-linked Fc glycosylation is not required for IgG-B-cell receptor function in a GC-derived B-cell line

Autori: Kissel T, Derksen VFAM, Bentlage AEH, Koeleman C, Hafkenscheid L, van der Woude D, Wuhrer M, Vidarsson G, Toes REM
Pubblicato in: Nature Communications, Numero 2024 Jan 9;15(1):393, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-44468-5

Autoreactive B cells in rheumatoid arthritis consist of activated CXCR3+ memory B cells and plasmablasts

Autori: Sanne Reijm, Joanneke C. Kwekkeboom, Nienke J. Blomberg, Jolien Suurmond, Diane van der Woude, Rene E.M. Toes, Hans U. Scherer
Pubblicato in: bioRxiv, 2023, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.05.19.538699

Antigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritis

Autori: Eva Maria Stork, Danique M. H. van Rijswijck, Karin A. van Schie, Max Hoek, Theresa Kissel, Hans Ulrich Scherer, Tom W. J. Huizinga, Albert J. R. Heck, Rene E. M. Toes, Albert Bondt
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-47337-x

Autoreactive B cells in extremes of rheumatoid arthritis disease phenotypes

Autori: Nienke J. Blomberg, Hendy Kristyanto, Marloes Verstappen, Sam Neppelenbroek, Annette H.M. van der Helm-van Mil, René E.M. Toes, Hans Ulrich Scherer
Pubblicato in: Annals of the Rheumatic Diseases, Numero 2025 Jun 17:S0003-4967(25)00965-3, 2025, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1016/j.ard.2025.05.006

Increased Phosphorylation of Intracellular Signaling Molecules Indicates Continuous Activation of Human Autoreactive B‐Cells

Autori: Sanne Kroos, Nienke J. Blomberg, Joanneke C. Kwekkeboom, Rudi W. Hendriks, Odilia B. J. Corneth, René E. M. Toes, Hans U. Scherer
Pubblicato in: European Journal of Immunology, Numero 55, 2025, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202451361

Multifunctional, Multivalent PIC Polymer Scaffolds for Targeting Antigen-Specific, Autoreactive B Cells

Autori: H. Kristyanto, M.D. Holborough-Kerkvliet, L. Lelieveldt, Y. Bartels, R. Hammink, K.A.J. van Schie, R.E.M. Toes, K.M. Bonger, H.U. Scherer
Pubblicato in: ACS biomaterials science & engineering, 2022, Pagina/e 1486-1493, ISSN 2373-9878
Editore: American Chemical Society
DOI: 10.1021/acsbiomaterials.1c01395

Acetylated bacterial proteins as potent antigens inducing an anti-modified protein antibody response

Autori: Mikhail Volkov, Arieke S B Kampstra, Karin A J van Schie, Anouk G van Mourik, Joanneke C Kwekkeboom, Arnoud de Ru, Peter A van Veelen, Tom W J Huizinga, René E M Toes, Diane van der Woude
Pubblicato in: RMD Open, Numero 10, 2024, Pagina/e e004411, ISSN 2056-5933
Editore: BMJ
DOI: 10.1136/rmdopen-2024-004411

Addressing the key issue: Antigen-specific targeting of B cells in autoimmune diseases

Autori: Holborough-Kerkvliet MD, Kroos S, van de Wetering R, Toes REM
Pubblicato in: Immunol Lett, Numero 259, 2023, Pagina/e 37-45, ISSN 0165-2478
Editore: Elsevier BV
DOI: 10.1016/j.imlet.2023.05.005

Checkpoints controlling the induction of B cell mediated autoimmunity in human autoimmune diseases

Autori: S. Reijm, T. Kissel, R.E.M. Toes
Pubblicato in: European Journal of Immunology, 2020, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048820

Non-peer reviewed articles (3)

Immune response to post-translationally modified proteins in rheumatoid arthritis: what makes it special?

Autori: Diane van der Woude, René E M Toes
Pubblicato in: Annals of the Rheumatic Diseases, Numero 83, 2025, Pagina/e 838-846, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/ard-2023-224103

The Autoantibody response in rheumatoid arthritis; what makes it unique?

Autori: Rene E.M. Toes
Pubblicato in: Seminars in Arthritis and Rheumatism, Numero 72, 2025, Pagina/e 152699, ISSN 0049-0172
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semarthrit.2025.152699

Autoantibodies in rheumatoid arthritis – rheumatoid factor, anticitrullinated protein antibodies and beyond

Autori: Günter Steiner, René E.M. Toes
Pubblicato in: Current Opinion in Rheumatology, Numero 36, 2025, Pagina/e 217-224, ISSN 1040-8711
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/bor.0000000000001006