Novel mechanisms of neurogenesis- from centrosome to engineering migration

Project Information

NeuroCentro

Grant agreement ID: 885382

DOI

10.3030/885382

EC signature date 6 May 2020

Start date 1 October 2020

End date 30 September 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 256 834,00

EU contribution

€ 2 256 834,00

Coordinated by

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (18)

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis

Author(s): Friess C., Götz M., Kjell J.
Published in: Journal of Visualized Experiments, 2021, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/63047

Probing cell identity hierarchies by fate titration and collision during direct reprogramming

Author(s): Hersbach B.A., Fischer D.S., Masserdotti G., Deeksha, Mojzisova K., Waltzhöni T., Rodriguez-Torrones D., Heinig M., Theis F. J., Götz M., Stricker S.H.
Published in: Molecular Systems Biology, 2022, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.15252/msb.202211129

Non-codon Optimized PiggyBac Transposase Induces Developmental Brain Aberrations: A Call for in vivo Analysis

Author(s): Vierl F., Kaur M. and Götz M.
Published in: Frontiers in Cell and Developmental Biology, Issue 9, 2021, Page(s) 698002, ISSN 2296-634X
Publisher: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2021.698002

Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain

Author(s): Swetlana Sirko, Christian Schichor, Patrizia Della Vecchia, Fabian Metzger, Giovanna Sonsalla, Tatiana Simon, Martina Bürkle, Sofia Kalpazidou, Jovica Ninkovic, Giacomo Masserdotti, Jean-Frederic Sauniere, Valentina Iacobelli, Stefano Iacobelli, Claire Delbridge, Stefanie M. Hauck, Jörg-Christian Tonn, Magdalena Götz
Published in: Nature Medicine, Issue 29, 2024, Page(s) 3149-3161, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-023-02644-6

Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity

Author(s): O’Neill A.C.*, Uzbas F.*, Antognolli G*., Merino F.*, Draganova K., Jäck A., Zhang S., Pedini G., Schessner J.P., Cramer K., Schepers A., Metzger F., Esgleas M., Smialowski P., Guerrini R., Falk S., Feederle R., Freytag S., Wang Z., Bahlo M., Jungmann R., Bagni C., Borner G.H.H., Robertson S.P., Hauck S.M., Götz M.
Published in: Science, 2022, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abf9088

Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno-Associated Viral Vector rAAV9P1

Author(s): Bauer A., Puglisi M., Nagl D., Schick J.A., Werner T., Klingl A., El Andari J., Hornung V., Kessler H., Götz M., Grimm D., Brack-Werner R.
Published in: Advanced Science, 2022, ISSN 2198-3844
Publisher: Wiley-VCH
DOI: 10.1002/advs.202104979

Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter

Author(s): Riccardo Bocchi, Manja Thorwirth, Tatiana Simon-Ebert, Christina Koupourtidou, Solène Clavreul, Keegan Kolf, Patrizia Della Vecchia, Sara Bottes, Sebastian Jessberger, Jiafeng Zhou, Gulzar Wani, Gregor-Alexander Pilz, Jovica Ninkovic, Annalisa Buffo, Swetlana Sirko, Magdalena Götz, Judith Fischer-Sternjak
Published in: Nature Neuroscience, Issue 28, 2025, Page(s) 457-469, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-025-01878-6

Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1

Author(s): Allwyn Pereira, Jeisimhan Diwakar, Giacomo Masserdotti, Sude Beşkardeş, Tatiana Simon, Younju So, Lucía Martín-Loarte, Franziska Bergemann, Lakshmy Vasan, Tamas Schauer, Anna Danese, Riccardo Bocchi, Maria Colomé-Tatché, Carol Schuurmans, Anna Philpott, Tobias Straub, Boyan Bonev, Magdalena Götz
Published in: Nature Neuroscience, Issue 27, 2024, Page(s) 1260-1273, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-024-01677-5

Centrosome heterogeneity in stem cells regulates cell diversity.

Author(s): Camargo Ortega G., Götz M.
Published in: Trends in Cell Biology, 2022, ISSN 1879-3088
Publisher: Elsevier
DOI: 10.1016/j.tcb.2022.03.004

Ribosome inactivation regulates translation elongation in neurons

Author(s): Bastian Popper, Martina Bürkle, Giuliana Ciccopiedi, Marta Marchioretto, Ignasi Forné, Axel Imhof, Tobias Straub, Gabriella Viero, Magdalena Götz, Rico Schieweck
Published in: Journal of Biological Chemistry, Issue 300, 2024, Page(s) 105648, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2024.105648

Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle

Author(s): Giovanna Sonsalla, Ana Belen Malpartida, Therese Riedemann, Mirjana Gusic, Ejona Rusha, Giorgia Bulli, Sonia Najas, Aleks Janjic, Bob A. Hersbach, Pawel Smialowski, Micha Drukker, Wolfgang Enard, Jochen H.M. Prehn, Holger Prokisch, Magdalena Götz, Giacomo Masserdotti
Published in: Neuron, Issue 112, 2024, Page(s) 1117-1132.e9, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2023.12.020

TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics

Author(s): Senís E., Esgleas M., Najas S., Jiménez-Sábado V., Bertani C., Giménez-Alejandre M., Escriche A., Ruiz-Orera J., Hergueta-Redondo M., Jiménez M., Giralt A., Nuciforo P., Albà M.M., Peinado H., Del Toro D., Hove-Madsen L., Götz M. and Abad M.
Published in: Frontiers in Cell and Developmental Biology, 2021, Page(s) 747667, ISSN 2296-634X
Publisher: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2021.747667

Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain

Author(s): Vinopal S., Dupraz S., Alfadil E., Petralla T., Bendre S., Stiess M., Falk S., Camargo Ortega G., Maghelli M., Tolic I.M., Smejkal J., Götz M., Bradke F.
Published in: Neuron, 2023, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2023.01.020

Brain injury environment critically influences the connectivity of transplanted neurons

Author(s): Grade S., Thomas J., Zarb Y., Thorwirth M., Conzelmann K.K., Hauck S.M.*, Götz M.*
Published in: Science Advances, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abg9445

Excessive local host-graft connectivity in aging and amyloid-loaded brain

Author(s): Thomas J., Martinez-Reza M.F., Thorwirth M., Zarb Y., Conzelmann K.K., Hauck S.M., Grade S.*, Götz M.*
Published in: Science Advances, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abg9287

Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches

Author(s): Bocchi R., Masserdotti G., Götz M.
Published in: Neuron, 2022, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2021.11.023

Pan-cellular organelles and suborganelles—from common functions to cellular diversity?

Author(s): Rico Schieweck, Magdalena Götz
Published in: Genes & Development, Issue 38, 2024, Page(s) 98-114, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.351337.123

Single Cell Deletion of the Transcription Factors Trps1 and Sox9 in Astrocytes Reveals Novel Functions in the Adult Cerebral Cortex

Author(s): Poornemaa Natarajan, Christina Koupourtidou, Thibault de Resseguier, Manja Thorwirth, Riccardo Bocchi, Judith Fischer‐Sternjak, Sarah Gleiss, Diana Rodrigues, Michael H. Myoga, Jovica Ninkovic, Giacomo Masserdotti, Magdalena Götz
Published in: Glia, Issue 73, 2025, Page(s) 737-758, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.24645

Non-peer reviewed articles (1)

Stem cells as role models for reprogramming and repair

Author(s): Magdalena Götz, Maria-Elena Torres-Padilla
Published in: Science, Issue 388, 2025, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adp2959