Novel mechanisms of neurogenesis- from centrosome to engineering migration

Información del proyecto

NeuroCentro

Identificador del acuerdo de subvención: 885382

DOI

10.3030/885382

Fecha de la firma de la CE 6 Mayo 2020

Fecha de inicio 1 Octubre 2020

Fecha de finalización 30 Septiembre 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 256 834,00

Aportación de la UE

€ 2 256 834,00

Coordinado por

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (18)

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis

Autores: Friess C., Götz M., Kjell J.
Publicado en: Journal of Visualized Experiments, 2021, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/63047

Probing cell identity hierarchies by fate titration and collision during direct reprogramming

Autores: Hersbach B.A., Fischer D.S., Masserdotti G., Deeksha, Mojzisova K., Waltzhöni T., Rodriguez-Torrones D., Heinig M., Theis F. J., Götz M., Stricker S.H.
Publicado en: Molecular Systems Biology, 2022, ISSN 1744-4292
Editor: Nature Publishing Group
DOI: 10.15252/msb.202211129

Non-codon Optimized PiggyBac Transposase Induces Developmental Brain Aberrations: A Call for in vivo Analysis

Autores: Vierl F., Kaur M. and Götz M.
Publicado en: Frontiers in Cell and Developmental Biology, Edición 9, 2021, Página(s) 698002, ISSN 2296-634X
Editor: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2021.698002

Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain

Autores: Swetlana Sirko, Christian Schichor, Patrizia Della Vecchia, Fabian Metzger, Giovanna Sonsalla, Tatiana Simon, Martina Bürkle, Sofia Kalpazidou, Jovica Ninkovic, Giacomo Masserdotti, Jean-Frederic Sauniere, Valentina Iacobelli, Stefano Iacobelli, Claire Delbridge, Stefanie M. Hauck, Jörg-Christian Tonn, Magdalena Götz
Publicado en: Nature Medicine, Edición 29, 2024, Página(s) 3149-3161, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-023-02644-6

Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity

Autores: O’Neill A.C.*, Uzbas F.*, Antognolli G*., Merino F.*, Draganova K., Jäck A., Zhang S., Pedini G., Schessner J.P., Cramer K., Schepers A., Metzger F., Esgleas M., Smialowski P., Guerrini R., Falk S., Feederle R., Freytag S., Wang Z., Bahlo M., Jungmann R., Bagni C., Borner G.H.H., Robertson S.P., Hauck S.M., Götz M.
Publicado en: Science, 2022, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abf9088

Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno-Associated Viral Vector rAAV9P1

Autores: Bauer A., Puglisi M., Nagl D., Schick J.A., Werner T., Klingl A., El Andari J., Hornung V., Kessler H., Götz M., Grimm D., Brack-Werner R.
Publicado en: Advanced Science, 2022, ISSN 2198-3844
Editor: Wiley-VCH
DOI: 10.1002/advs.202104979

Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter

Autores: Riccardo Bocchi, Manja Thorwirth, Tatiana Simon-Ebert, Christina Koupourtidou, Solène Clavreul, Keegan Kolf, Patrizia Della Vecchia, Sara Bottes, Sebastian Jessberger, Jiafeng Zhou, Gulzar Wani, Gregor-Alexander Pilz, Jovica Ninkovic, Annalisa Buffo, Swetlana Sirko, Magdalena Götz, Judith Fischer-Sternjak
Publicado en: Nature Neuroscience, Edición 28, 2025, Página(s) 457-469, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-025-01878-6

Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1

Autores: Allwyn Pereira, Jeisimhan Diwakar, Giacomo Masserdotti, Sude Beşkardeş, Tatiana Simon, Younju So, Lucía Martín-Loarte, Franziska Bergemann, Lakshmy Vasan, Tamas Schauer, Anna Danese, Riccardo Bocchi, Maria Colomé-Tatché, Carol Schuurmans, Anna Philpott, Tobias Straub, Boyan Bonev, Magdalena Götz
Publicado en: Nature Neuroscience, Edición 27, 2024, Página(s) 1260-1273, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-024-01677-5

Centrosome heterogeneity in stem cells regulates cell diversity.

Autores: Camargo Ortega G., Götz M.
Publicado en: Trends in Cell Biology, 2022, ISSN 1879-3088
Editor: Elsevier
DOI: 10.1016/j.tcb.2022.03.004

Ribosome inactivation regulates translation elongation in neurons

Autores: Bastian Popper, Martina Bürkle, Giuliana Ciccopiedi, Marta Marchioretto, Ignasi Forné, Axel Imhof, Tobias Straub, Gabriella Viero, Magdalena Götz, Rico Schieweck
Publicado en: Journal of Biological Chemistry, Edición 300, 2024, Página(s) 105648, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2024.105648

Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle

Autores: Giovanna Sonsalla, Ana Belen Malpartida, Therese Riedemann, Mirjana Gusic, Ejona Rusha, Giorgia Bulli, Sonia Najas, Aleks Janjic, Bob A. Hersbach, Pawel Smialowski, Micha Drukker, Wolfgang Enard, Jochen H.M. Prehn, Holger Prokisch, Magdalena Götz, Giacomo Masserdotti
Publicado en: Neuron, Edición 112, 2024, Página(s) 1117-1132.e9, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2023.12.020

TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics

Autores: Senís E., Esgleas M., Najas S., Jiménez-Sábado V., Bertani C., Giménez-Alejandre M., Escriche A., Ruiz-Orera J., Hergueta-Redondo M., Jiménez M., Giralt A., Nuciforo P., Albà M.M., Peinado H., Del Toro D., Hove-Madsen L., Götz M. and Abad M.
Publicado en: Frontiers in Cell and Developmental Biology, 2021, Página(s) 747667, ISSN 2296-634X
Editor: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2021.747667

Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain

Autores: Vinopal S., Dupraz S., Alfadil E., Petralla T., Bendre S., Stiess M., Falk S., Camargo Ortega G., Maghelli M., Tolic I.M., Smejkal J., Götz M., Bradke F.
Publicado en: Neuron, 2023, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2023.01.020

Brain injury environment critically influences the connectivity of transplanted neurons

Autores: Grade S., Thomas J., Zarb Y., Thorwirth M., Conzelmann K.K., Hauck S.M.*, Götz M.*
Publicado en: Science Advances, 2022, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abg9445

Excessive local host-graft connectivity in aging and amyloid-loaded brain

Autores: Thomas J., Martinez-Reza M.F., Thorwirth M., Zarb Y., Conzelmann K.K., Hauck S.M., Grade S.*, Götz M.*
Publicado en: Science Advances, 2022, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abg9287

Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches

Autores: Bocchi R., Masserdotti G., Götz M.
Publicado en: Neuron, 2022, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2021.11.023

Pan-cellular organelles and suborganelles—from common functions to cellular diversity?

Autores: Rico Schieweck, Magdalena Götz
Publicado en: Genes & Development, Edición 38, 2024, Página(s) 98-114, ISSN 0890-9369
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.351337.123

Single Cell Deletion of the Transcription Factors Trps1 and Sox9 in Astrocytes Reveals Novel Functions in the Adult Cerebral Cortex

Autores: Poornemaa Natarajan, Christina Koupourtidou, Thibault de Resseguier, Manja Thorwirth, Riccardo Bocchi, Judith Fischer‐Sternjak, Sarah Gleiss, Diana Rodrigues, Michael H. Myoga, Jovica Ninkovic, Giacomo Masserdotti, Magdalena Götz
Publicado en: Glia, Edición 73, 2025, Página(s) 737-758, ISSN 0894-1491
Editor: John Wiley & Sons Inc.
DOI: 10.1002/glia.24645

Non-peer reviewed articles (1)

Stem cells as role models for reprogramming and repair

Autores: Magdalena Götz, Maria-Elena Torres-Padilla
Publicado en: Science, Edición 388, 2025, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.adp2959