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Accurate, Reliable and Optimized functional MAgnetic resonance imaging at unprecedented field strength for unique exploration of the human brain

Project description

Novel high-resolution magnetic resonance imaging for human brain exploration

The EU-funded AROMA project aims to enable in vivo non-invasive exploration of cognitive functions of the human brain at the mesoscopic scale. This achievement will include the introduction of non-incremental magnetic resonance imaging technology at the unprecedented field strength of 11.7 tesla. The project involves a multidisciplinary effort of six partners from five countries representing academia and industry. The proposal presents solutions to overcome fundamental barriers to exploit the full potential of the unique MRI instrument. Successful completion of the project will benefit clinical applications, including computational psychiatry, and will help to decipher mechanisms of words encoding, mathematics and conscious thoughts.

Objective

The AROMA project will provide the means enabling in vivo non-invasive exploration of cognitive functions of the human brain at the mesoscopic scale (500 μm). This will be achieved with non-incremental Magnetic Resonance Imaging (MRI) technologies at unprecedented field strength (11.7 Tesla).
The following ambitious objectives are considered:
-Maximize signal by means of advanced sequence developments, innovative coil designs, motion correction and paradigm shift radiofrequency pulse designs.
-Exploit the emerging field sensors technology to minimize the noise induced by subject’s motion and physiology to achieve the functional targeted detection sensitivity.
-Test and validate the disruptive scientific progress with tens of healthy adult volunteers for validation of the anatomical scan quality as well as reliable detection of cortical-depth dependent neural activations.
AROMA is a multidisciplinary project engaging 6 EU partners (with young researchers and first-time participants to FET) from 5 countries (France, Germany, Switzerland, Netherlands and United Kingdom) covering the academic and industrial worlds. An implementation plan is presented in the form of 5 work packages, 4 of which are technical in nature. Synergy in communication and dissemination by the several partners and stakeholders (external advisory board, letters of intent are provided) will permit to maximize AROMA project impact.
The proposal presents solutions to overcome the fundamental barriers and considers appropriate deliverables, tasks, milestones and risks in order to complete the project objectives in due time. Medical sector will be impacted by the AROMA project outcomes, with implications for computational psychiatry and deciphering the encoding of words, mathematical objects and conscious thoughts. The arsenal of techniques deployed in the project will constitute paradigm shifts with a unified solution, and with commercial opportunities and benefits for the MRI industry in general.

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

RIA - Research and Innovation action

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-FETOPEN-2018-2020

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Coordinator

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 931 126,25
Address
RUE LEBLANC 25
75015 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 931 126,25

Participants (5)

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